{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:57:18Z","timestamp":1787065038413,"version":"build-2736575974"},"reference-count":102,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2018,7,2]],"date-time":"2018-07-02T00:00:00Z","timestamp":1530489600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"German Federal Ministry of Education and Research","award":["031L0073A"],"award-info":[{"award-number":["031L0073A"]}]},{"name":"eBio: SysMet","award":["0316171"],"award-info":[{"award-number":["0316171"]}]},{"name":"ELAN-fund of Universit\u00e4tsklinikum Erlangen","award":["16-08-16-1-Lai"],"award-info":[{"award-number":["16-08-16-1-Lai"]}]},{"DOI":"10.13039\/501100001171","name":"Cancer Institute NSW","doi-asserted-by":"publisher","award":["ECF171267"],"award-info":[{"award-number":["ECF171267"]}],"id":[{"id":"10.13039\/501100001171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Motivation<\/jats:title><jats:p>Extracellular vesicles (EVs), including exosomes and microvesicles, are potent and clinically valuable tools for early diagnosis, prognosis and potentially the targeted treatment of cancer. The content of EVs is closely related to the type and status of the EV-secreting cell. Circulating exosomes are a source of stable RNAs including mRNAs, microRNAs and long non-coding RNAs (lncRNAs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>This review outlines the links between EVs, lncRNAs and cancer. We highlight communication networks involving the tumor microenvironment, the immune system and metastasis. We show examples supporting the value of exosomal lncRNAs as cancer biomarkers and therapeutic targets. We demonstrate how a system biology approach can be used to model cell\u2013cell communication via exosomal lncRNAs and to simulate effects of therapeutic interventions. In addition, we introduce algorithms and bioinformatics resources for the discovery of tumor-specific lncRNAs and tools that are applied to determine exosome content and lncRNA function. Finally, this review provides a comprehensive collection and guide to databases for exosomal lncRNAs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Supplementary information<\/jats:title><jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p><\/jats:sec>","DOI":"10.1093\/bioinformatics\/bty527","type":"journal-article","created":{"date-parts":[[2018,6,28]],"date-time":"2018-06-28T11:56:38Z","timestamp":1530186998000},"page":"352-360","source":"Crossref","is-referenced-by-count":60,"title":["Exosomal lncRNAs and cancer: connecting the missing links"],"prefix":"10.1093","volume":"35","author":[{"given":"Hojjat","family":"Naderi-Meshkin","sequence":"first","affiliation":[{"name":"Stem Cells & Regenerative Medicine Research Group, Academic Center for Education, Culture Research (ACECR), Khorasan Razavi Branch, Mashhad, Iran"},{"name":"Nastaran Center for Cancer Prevention, Mashhad, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Lai","sequence":"additional","affiliation":[{"name":"Laboratory of Systems Tumour Immunology, Department of Dermatology, Friedrich-Alexander-University of Erlangen-N\u00fcrnberg (FAU) and Universit\u00e4tsklinikum Erlangen, Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raheleh","family":"Amirkhah","sequence":"additional","affiliation":[{"name":"Nastaran Center for Cancer Prevention, Mashhad, Iran"},{"name":"Reza Institute of Cancer Bioinformatics and Personalized Medicine, Mashhad, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio","family":"Vera","sequence":"additional","affiliation":[{"name":"Laboratory of Systems Tumour Immunology, Department of Dermatology, Friedrich-Alexander-University of Erlangen-N\u00fcrnberg (FAU) and Universit\u00e4tsklinikum Erlangen, Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John E J","family":"Rasko","sequence":"additional","affiliation":[{"name":"Gene and Stem Cell Therapy Program, Centenary Institute, University of Sydney, Camperdown, Australia"},{"name":"Sydney Medical School, University of Sydney, Camperdown, Australia"},{"name":"Cell and Molecular Therapies, Royal Prince Alfred Hospital, Camperdown, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulf","family":"Schmitz","sequence":"additional","affiliation":[{"name":"Gene and Stem Cell Therapy Program, Centenary Institute, University of Sydney, Camperdown, Australia"},{"name":"Sydney Medical School, University of Sydney, Camperdown, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,7,2]]},"reference":[{"key":"2023013107225696100_bty527-B1","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1186\/s13046-017-0587-0","article-title":"Exosomes isolated from cancer patients\u2019 sera transfer malignant traits and confer the same phenotype of primary tumors to oncosuppressor-mutated cells","volume":"36","author":"Abdouh","year":"2017","journal-title":"J. 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