{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T15:39:01Z","timestamp":1778945941879,"version":"3.51.4"},"reference-count":66,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2018,7,2]],"date-time":"2018-07-02T00:00:00Z","timestamp":1530489600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["GM108348"],"award-info":[{"award-number":["GM108348"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"NSF","doi-asserted-by":"publisher","award":["1619081"],"award-info":[{"award-number":["1619081"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Cancer Genome Collaboratory"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Motivation<\/jats:title>\n                  <jats:p>Recent advances in genomics and precision medicine have been made possible through the application of high throughput sequencing (HTS) to large collections of human genomes. Although HTS technologies have proven their use in cataloging human genome variation, computational analysis of the data they generate is still far from being perfect. The main limitation of Illumina and other popular sequencing technologies is their short read length relative to the lengths of (common) genomic repeats. Newer (single molecule sequencing \u2013 SMS) technologies such as Pacific Biosciences and Oxford Nanopore are producing longer reads, making it theoretically possible to overcome the difficulties imposed by repeat regions. Unfortunately, because of their high sequencing error rate, reads generated by these technologies are very difficult to work with and cannot be used in many of the standard downstream analysis pipelines. Note that it is not only difficult to find the correct mapping locations of such reads in a reference genome, but also to establish their correct alignment so as to differentiate sequencing errors from real genomic variants. Furthermore, especially since newer SMS instruments provide higher throughput, mapping and alignment need to be performed much faster than before, maintaining high sensitivity.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We introduce lordFAST, a novel long-read mapper that is specifically designed to align reads generated by PacBio and potentially other SMS technologies to a reference. lordFAST not only has higher sensitivity than the available alternatives, it is also among the fastest and has a very low memory footprint.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availability and implementation<\/jats:title>\n                  <jats:p>lordFAST is implemented in C++ and supports multi-threading. The source code of lordFAST is available at https:\/\/github.com\/vpc-ccg\/lordfast.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Supplementary information<\/jats:title>\n                  <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/bty544","type":"journal-article","created":{"date-parts":[[2018,6,29]],"date-time":"2018-06-29T03:10:31Z","timestamp":1530241831000},"page":"20-27","source":"Crossref","is-referenced-by-count":24,"title":["lordFAST: sensitive and Fast Alignment Search Tool for LOng noisy Read sequencing Data"],"prefix":"10.1093","volume":"35","author":[{"given":"Ehsan","family":"Haghshenas","sequence":"first","affiliation":[{"name":"School of Computing Science, Simon Fraser University, Burnaby, BC, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S Cenk","family":"Sahinalp","sequence":"additional","affiliation":[{"name":"School of Computing Science, Simon Fraser University, Burnaby, BC, Canada"},{"name":"School of Informatics and Computing, Indiana University, Bloomington, IN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1143-0172","authenticated-orcid":false,"given":"Faraz","family":"Hach","sequence":"additional","affiliation":[{"name":"Vancouver Prostate Centre, Vancouver, BC, Canada"},{"name":"Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2018,7,2]]},"reference":[{"key":"2023013107195740600_bty544-B1","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1038\/nature09534","article-title":"A map of human genome variation from population-scale sequencing","volume":"467","author":"1000 Genomes Project Consortium","year":"2010","journal-title":"Nature"},{"key":"2023013107195740600_bty544-B2","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/nature11632","article-title":"An integrated map of genetic variation from 1, 092 human genomes","volume":"491","author":"1000 Genomes Project Consortium","year":"2012","journal-title":"Nature"},{"key":"2023013107195740600_bty544-B3","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1038\/ng.437","article-title":"Personalized copy number and segmental duplication maps using next-generation sequencing","volume":"41","author":"Alkan","year":"2009","journal-title":"Nat. Genet"},{"key":"2023013107195740600_bty544-B4","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/nrg2958","article-title":"Genome structural variation discovery and genotyping","volume":"12","author":"Alkan","year":"2011","journal-title":"Nat. Rev. Genet"},{"key":"2023013107195740600_bty544-B5","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/nbt.2288","article-title":"A hybrid approach for the automated finishing of bacterial genomes","volume":"30","author":"Bashir","year":"2012","journal-title":"Nat. Biotechnol"},{"key":"2023013107195740600_bty544-B6","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/nbt.3238","article-title":"Assembling large genomes with single-molecule sequencing and locality-sensitive hashing","volume":"33","author":"Berlin","year":"2015","journal-title":"Nat. Biotechnol"},{"key":"2023013107195740600_bty544-B7","doi-asserted-by":"crossref","first-page":"40.","DOI":"10.1186\/1754-6834-7-40","article-title":"Comparison of single-molecule sequencing and hybrid approaches for finishing the genome of clostridium autoethanogenum and analysis of CRISPR systems in industrial relevant clostridia","volume":"7","author":"Brown","year":"2014","journal-title":"Biotechnol. Biofuels"},{"key":"2023013107195740600_bty544-B8","author":"Burrows","year":"1994"},{"key":"2023013107195740600_bty544-B9","doi-asserted-by":"crossref","first-page":"238.","DOI":"10.1186\/1471-2105-13-238","article-title":"Mapping single molecule sequencing reads using basic local alignment with successive refinement (blasr): application and theory","volume":"13","author":"Chaisson","year":"2012","journal-title":"BMC Bioinformatics"},{"key":"2023013107195740600_bty544-B10","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1038\/nature13907","article-title":"Resolving the complexity of the human genome using single-molecule sequencing","volume":"517","author":"Chaisson","year":"2015","journal-title":"Nature"},{"key":"2023013107195740600_bty544-B11","first-page":"117","volume-title":"International Conference on Research in Computational Molecular Biology","author":"Chaisson","year":"2017"},{"key":"2023013107195740600_bty544-B12","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1038\/nbt.2147","article-title":"Automated forward and reverse ratcheting of dna in a nanopore at 5-a precision","volume":"30","author":"Cherf","year":"2012","journal-title":"Nat. Biotechnol"},{"key":"2023013107195740600_bty544-B13","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1038\/nmeth.2474","article-title":"Nonhybrid, finished microbial genome assemblies from long-read smrt sequencing data","volume":"10","author":"Chin","year":"2013","journal-title":"Nat. Methods"},{"key":"2023013107195740600_bty544-B14","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1093\/bioinformatics\/btr046","article-title":"Shrimp2: sensitive yet practical short read mapping","volume":"27","author":"David","year":"2011","journal-title":"Bioinformatics"},{"key":"2023013107195740600_bty544-B15","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1093\/bioinformatics\/btt647","article-title":"Rapid detection of expanded short tandem repeats in personal genomics using hybrid sequencing","volume":"30","author":"Doi","year":"2014","journal-title":"Bioinformatics"},{"key":"2023013107195740600_bty544-B16","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1126\/science.1162986","article-title":"Real-time dna sequencing from single polymerase molecules","volume":"323","author":"Eid","year":"2009","journal-title":"Science"},{"key":"2023013107195740600_bty544-B17","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/nbt0412-295","article-title":"Oxford nanopore announcement sets sequencing sector abuzz","volume":"30","author":"Eisenstein","year":"2012","journal-title":"Nat. Biotechnol"},{"key":"2023013107195740600_bty544-B18","doi-asserted-by":"crossref","first-page":"e47768.","DOI":"10.1371\/journal.pone.0047768","article-title":"Mind the gap: upgrading genomes with pacific biosciences rs long-read sequencing technology","volume":"7","author":"English","year":"2012","journal-title":"PLoS One"},{"key":"2023013107195740600_bty544-B19","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1101\/gr.214767.116","article-title":"Hysa: a hybrid structural variant assembly approach using next-generation and single-molecule sequencing technologies","volume":"27","author":"Fan","year":"2017","journal-title":"Genome Res"},{"key":"2023013107195740600_bty544-B20","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1109\/SFCS.2000.892127","article-title":"Opportunistic data structures with applications","author":"Ferragina","year":"2000","journal-title":"Proceedings 41st Annual Symposium on Foundations of Computer Science (FOCS'00)"},{"key":"2023013107195740600_bty544-B21","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1073\/pnas.1017351108","article-title":"High-quality draft assemblies of mammalian genomes from massively parallel sequence data","volume":"108","author":"Gnerre","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2023013107195740600_bty544-B22","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1093\/bioinformatics\/bts712","article-title":"SRmapper: a fast and sensitive genome-hashing alignment tool","volume":"29","author":"Gontarz","year":"2013","journal-title":"Bioinformatics"},{"key":"2023013107195740600_bty544-B23","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1101\/gr.191395.115","article-title":"Oxford nanopore sequencing, hybrid error correction, and de novo assembly of a eukaryotic genome","volume":"25","author":"Goodwin","year":"2015","journal-title":"Genome Res"},{"key":"2023013107195740600_bty544-B24","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1038\/nmeth0810-576","article-title":"mrsfast: a cache-oblivious algorithm for short-read mapping","volume":"7","author":"Hach","year":"2010","journal-title":"Nat. Methods"},{"key":"2023013107195740600_bty544-B25","doi-asserted-by":"crossref","first-page":"gku370","DOI":"10.1093\/nar\/gku370","article-title":"mrsfast-ultra: a compact, snp-aware mapper for high performance sequencing applications","volume":"42","author":"Hach","year":"2014","journal-title":"Nucleic Acids Res"},{"key":"2023013107195740600_bty544-B26","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1101\/gr.088633.108","article-title":"Combinatorial algorithms for structural variation detection in high-throughput sequenced genomes","volume":"19","author":"Hormozdiari","year":"2009","journal-title":"Genome Res"},{"key":"2023013107195740600_bty544-B27","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1101\/gr.168450.113","article-title":"Reconstructing complex regions of genomes using long-read sequencing technology","volume":"24","author":"Huddleston","year":"2014","journal-title":"Genome Res"},{"key":"2023013107195740600_bty544-B28","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1101\/gr.214007.116","article-title":"Discovery and genotyping of structural variation from long-read haploid genome sequence data","volume":"27","author":"Huddleston","year":"2017","journal-title":"Genome Res"},{"key":"2023013107195740600_bty544-B29","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/nbt.2280","article-title":"Hybrid error correction and de novo assembly of single-molecule sequencing reads","volume":"30","author":"Koren","year":"2012","journal-title":"Nat. Biotechnol"},{"key":"2023013107195740600_bty544-B30","doi-asserted-by":"crossref","first-page":"R101.","DOI":"10.1186\/gb-2013-14-9-r101","article-title":"Reducing assembly complexity of microbial genomes with single-molecule sequencing","volume":"14","author":"Koren","year":"2013","journal-title":"Genome Biol"},{"key":"2023013107195740600_bty544-B31","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/S0076-6879(10)72001-2","article-title":"Real-time dna sequencing from single polymerase molecules","volume":"472","author":"Korlach","year":"2010","journal-title":"Methods Enzymol"},{"key":"2023013107195740600_bty544-B32","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.1923","article-title":"Fast gapped-read alignment with Bowtie 2","volume":"9","author":"Langmead","year":"2012","journal-title":"Nat. Methods"},{"key":"2023013107195740600_bty544-B33","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1093\/bioinformatics\/bts280","article-title":"Exploring single-sample snp and indel calling with whole-genome de novo assembly","volume":"28","author":"Li","year":"2012","journal-title":"Bioinformatics"},{"key":"2023013107195740600_bty544-B34","first-page":"3997","article-title":"Aligning sequence reads, clone sequences and assembly contigs with bwa-mem","volume":"1303","author":"Li","year":"2013","journal-title":"arXiv"},{"key":"2023013107195740600_bty544-B35","first-page":"7","article-title":"Minimap2: pairwise alignment for nucleotide sequences","volume":"1","author":"Li","year":"2018","journal-title":"Bioinformatics"},{"key":"2023013107195740600_bty544-B36","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1093\/bioinformatics\/btp324","article-title":"Fast and accurate short read alignment with Burrows-Wheeler transform","volume":"25","author":"Li","year":"2009","journal-title":"Bioinformatics"},{"key":"2023013107195740600_bty544-B37","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1093\/bioinformatics\/btp336","article-title":"SOAP2: an improved ultrafast tool for short read alignment","volume":"25","author":"Li","year":"2009","journal-title":"Bioinformatics"},{"key":"2023013107195740600_bty544-B38","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1093\/bioinformatics\/btn416","article-title":"Zoom! zillions of oligos mapped","volume":"24","author":"Lin","year":"2008","journal-title":"Bioinformatics"},{"key":"2023013107195740600_bty544-B39","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1093\/bioinformatics\/btv662","article-title":"rhat: fast alignment of noisy long reads with regional hashing","volume":"32","author":"Liu","year":"2016","journal-title":"Bioinformatics"},{"key":"2023013107195740600_bty544-B40","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1093\/bioinformatics\/btw594","article-title":"Lamsa: fast split read alignment with long approximate matches","volume":"33","author":"Liu","year":"2017","journal-title":"Bioinformatics"},{"key":"2023013107195740600_bty544-B41","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1038\/nmeth.3444","article-title":"A complete bacterial genome assembled de novo using only nanopore sequencing data","volume":"12","author":"Loman","year":"2015","journal-title":"Nat. Methods"},{"key":"2023013107195740600_bty544-B42","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1137\/0222058","article-title":"Suffix arrays: a new method for on-line string searches","volume":"22","author":"Manber","year":"1993","journal-title":"SIAM J. Comput"},{"key":"2023013107195740600_bty544-B43","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/nbt.2171","article-title":"Reading dna at single-nucleotide resolution with a mutant MsPa nanopore and phi29 dna polymerase","volume":"30","author":"Manrao","year":"2012","journal-title":"Nat. Biotechnol"},{"key":"2023013107195740600_bty544-B44","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1038\/nmeth.2221","article-title":"The GEM mapper: fast, accurate and versatile alignment by filtration","volume":"9","author":"Marco-Sola","year":"2012","journal-title":"Nat. Methods"},{"key":"2023013107195740600_bty544-B45","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/nature03959","article-title":"Genome sequencing in microfabricated high-density picolitre reactors","volume":"437","author":"Margulies","year":"2005","journal-title":"Nature"},{"key":"2023013107195740600_bty544-B46","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1145\/316542.316550","article-title":"A fast bit-vector algorithm for approximate string matching based on dynamic programming","volume":"46","author":"Myers","year":"1999","journal-title":"JACM"},{"key":"2023013107195740600_bty544-B47","author":"Ohlebusch","year":"2005","journal-title":"Chaining Algorithms and Applications in Comparative Genomics"},{"key":"2023013107195740600_bty544-B48","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1093\/bioinformatics\/bts649","article-title":"PBSIM: PacBio reads simulator toward accurate genome assembly","volume":"29","author":"Ono","year":"2013","journal-title":"Bioinformatics"},{"key":"2023013107195740600_bty544-B49","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/ng.835","article-title":"Exome sequencing in sporadic autism spectrum disorders identifies severe de novo mutations","volume":"43","author":"O'Roak","year":"2011","journal-title":"Nat. Genet"},{"key":"2023013107195740600_bty544-B50","doi-asserted-by":"crossref","first-page":"4.","DOI":"10.1186\/1748-7188-6-4","article-title":"Fast local fragment chaining using sum-of-pair gap costs","volume":"6","author":"Otto","year":"2011","journal-title":"Algorithms Mol. Biol"},{"key":"2023013107195740600_bty544-B51","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1038\/nmeth.3454","article-title":"Assembly and diploid architecture of an individual human genome via single-molecule technologies","volume":"12","author":"Pendleton","year":"2015","journal-title":"Nat. Methods"},{"key":"2023013107195740600_bty544-B52","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/nmeth.4189","article-title":"Mapping dna methylation with high-throughput nanopore sequencing","volume":"14","author":"Rand","year":"2017","journal-title":"Nat. Methods"},{"key":"2023013107195740600_bty544-B151","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/s13059-018-1462-9","article-title":"From squiggle to basepair: computational approaches for improving nanopore sequencing read accuracy","volume":"19","author":"Rang","year":"2018","journal-title":"Genome Biol."},{"key":"2023013107195740600_bty544-B53","doi-asserted-by":"crossref","first-page":"3363","DOI":"10.1093\/bioinformatics\/bth408","article-title":"Reducing storage requirements for biological sequence comparison","volume":"20","author":"Roberts","year":"2004","journal-title":"Bioinformatics"},{"key":"2023013107195740600_bty544-B54","first-page":"1","article-title":"Comparison of genome sequencing technology and assembly methods for the analysis of a GC-rich bacterial genome","volume":"70","author":"Scott","year":"2014","journal-title":"Curr. Microbiol"},{"key":"2023013107195740600_bty544-B55","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/s41592-018-0001-7","article-title":"Accurate detection of complex structural variations using single-molecule sequencing","volume":"15","author":"Sedlazeck","year":"2018","journal-title":"Nat. Methods"},{"key":"2023013107195740600_bty544-B56","doi-asserted-by":"crossref","first-page":"e68824.","DOI":"10.1371\/journal.pone.0068824","article-title":"Advantages of single-molecule real-time sequencing in high-GC content genomes","volume":"8","author":"Shin","year":"2013","journal-title":"PLoS One"},{"key":"2023013107195740600_bty544-B57","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/nmeth.4184","article-title":"Detecting DNA cytosine methylation using nanopore sequencing","volume":"14","author":"Simpson","year":"2017","journal-title":"Nat. Methods"},{"key":"2023013107195740600_bty544-B58","doi-asserted-by":"crossref","first-page":"e78.","DOI":"10.1093\/nar\/gkt005","article-title":"Fast and accurate read mapping with approximate seeds and multiple backtracking","volume":"41","author":"Siragusa","year":"2013","journal-title":"Nucleic Acids Res"},{"key":"2023013107195740600_bty544-B59","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1093\/bioinformatics\/btw753","article-title":"Edlib: a c\/c++ library for fast, exact sequence alignment using edit distance","volume":"33","author":"\u0160o\u0161i\u0107","year":"2017","journal-title":"Bioinformatics"},{"key":"2023013107195740600_bty544-B60","doi-asserted-by":"crossref","first-page":"11307","DOI":"10.1038\/ncomms11307","article-title":"Fast and sensitive mapping of nanopore sequencing reads with GraphMap","volume":"7","author":"Sovi\u0107","year":"2016","journal-title":"Nat. Commun"},{"key":"2023013107195740600_bty544-B61","doi-asserted-by":"crossref","first-page":"217.","DOI":"10.1186\/gb-2011-12-2-217","article-title":"The properties and applications of single-molecule DNA sequencing","volume":"12","author":"Thompson","year":"2011","journal-title":"Genome Biol"},{"key":"2023013107195740600_bty544-B62","doi-asserted-by":"crossref","first-page":"e159","DOI":"10.1093\/nar\/gkq543","article-title":"A flexible and efficient template format for circular consensus sequencing and snp detection","volume":"38","author":"Travers","year":"2010","journal-title":"Nucleic Acids Res"},{"key":"2023013107195740600_bty544-B63","doi-asserted-by":"crossref","first-page":"3491","DOI":"10.1093\/bioinformatics\/btu437","article-title":"Resolving complex tandem repeats with long reads","volume":"30","author":"Ummat","year":"2014","journal-title":"Bioinformatics"},{"key":"2023013107195740600_bty544-B64","doi-asserted-by":"crossref","first-page":"2592","DOI":"10.1093\/bioinformatics\/bts505","article-title":"Razers 3: faster, fully sensitive read mapping","volume":"28","author":"Weese","year":"2012","journal-title":"Bioinformatics"},{"key":"2023013107195740600_bty544-B65","doi-asserted-by":"crossref","first-page":"S13.","DOI":"10.1186\/1471-2164-14-S1-S13","article-title":"Accelerating read mapping with fastHASH","volume":"14 (Suppl. 1)","author":"Xin","year":"2013","journal-title":"BMC Genomics"}],"container-title":["Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/35\/1\/20\/48962073\/bioinformatics_35_1_20.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/35\/1\/20\/48962073\/bioinformatics_35_1_20.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,31]],"date-time":"2023-01-31T09:59:54Z","timestamp":1675159194000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article\/35\/1\/20\/5047762"}},"subtitle":[],"editor":[{"given":"Bonnie","family":"Berger","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2018,7,2]]},"references-count":66,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1,1]]}},"URL":"https:\/\/doi.org\/10.1093\/bioinformatics\/bty544","relation":{},"ISSN":["1367-4803","1367-4811"],"issn-type":[{"value":"1367-4803","type":"print"},{"value":"1367-4811","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,1,1]]},"published":{"date-parts":[[2018,7,2]]}}}