{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T20:22:59Z","timestamp":1780518179282,"version":"3.54.1"},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2018,7,2]],"date-time":"2018-07-02T00:00:00Z","timestamp":1530489600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["HG000376"],"award-info":[{"award-number":["HG000376"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["HG009976 (MB)"],"award-info":[{"award-number":["HG009976 (MB)"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["HG007022"],"award-info":[{"award-number":["HG007022"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["HG006513"],"award-info":[{"award-number":["HG006513"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["U01HL137182"],"award-info":[{"award-number":["U01HL137182"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Summary<\/jats:title>\n                    <jats:p>Estimating linkage disequilibrium (LD) is essential for a wide range of summary statistics-based association methods for genome-wide association studies. Large genetic datasets, e.g. the TOPMed WGS project and UK Biobank, enable more accurate and comprehensive LD estimates, but increase the computational burden of LD estimation. Here, we describe emeraLD (Efficient Methods for Estimation and Random Access of LD), a computational tool that leverages sparsity and haplotype structure to estimate LD up to 2 orders of magnitude faster than current tools.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Availability and implementation<\/jats:title>\n                    <jats:p>emeraLD is implemented in C++, and is open source under GPLv3. Source code and documentation are freely available at http:\/\/github.com\/statgen\/emeraLD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Supplementary information<\/jats:title>\n                    <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bioinformatics\/bty547","type":"journal-article","created":{"date-parts":[[2018,6,28]],"date-time":"2018-06-28T23:10:31Z","timestamp":1530227431000},"page":"164-166","source":"Crossref","is-referenced-by-count":17,"title":["emeraLD: rapid linkage disequilibrium estimation with massive datasets"],"prefix":"10.1093","volume":"35","author":[{"given":"Corbin","family":"Quick","sequence":"first","affiliation":[{"name":"Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Fuchsberger","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA"},{"name":"Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of L\u00fcbeck, Bolzano, Italy"},{"name":"Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Medical University of Innsbruck, Innsbruck, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Taliun","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gon\u00e7alo","family":"Abecasis","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Boehnke","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Min","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,7,2]]},"reference":[{"key":"2023013107213350200_bty547-B1","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/nature15393","article-title":"A global reference for human genetic variation","volume":"526","author":"1000 Genomes Project Consortium","year":"2015","journal-title":"Nature"},{"key":"2023013107213350200_bty547-B2","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.ajhg.2017.08.012","article-title":"Prospects of fine-mapping trait-associated genomic regions by using summary statistics from genome-wide association studies","volume":"101","author":"Benner","year":"2017","journal-title":"Am. 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