{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T20:13:24Z","timestamp":1770840804165,"version":"3.50.1"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2018,7,7]],"date-time":"2018-07-07T00:00:00Z","timestamp":1530921600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81401114"],"award-info":[{"award-number":["81401114"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31571312"],"award-info":[{"award-number":["31571312"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Key Plan for Scientific Research and Development of China","award":["2016YFC1306000"],"award-info":[{"award-number":["2016YFC1306000"]}]},{"DOI":"10.13039\/501100012486","name":"Innovation-Driven Project of Central South University","doi-asserted-by":"crossref","award":["2015CXS034"],"award-info":[{"award-number":["2015CXS034"]}],"id":[{"id":"10.13039\/501100012486","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012486","name":"Innovation-Driven Project of Central South University","doi-asserted-by":"crossref","award":["2018CX033"],"award-info":[{"award-number":["2018CX033"]}],"id":[{"id":"10.13039\/501100012486","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["1 U01 MH103340-01"],"award-info":[{"award-number":["1 U01 MH103340-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["1R01ES024988"],"award-info":[{"award-number":["1R01ES024988"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Summary<\/jats:title>\n                  <jats:p>Gene expression changes over the lifespan and varies among different tissues or cell types. Gene co-expression also changes by sex, age, different tissues or cell types. However, gene expression under the normal state and gene co-expression in the human brain has not been fully defined and quantified. Here we present a database named Brain EXPression Database (BrainEXP) which provides spatiotemporal expression of individual genes and co-expression in normal human brains. BrainEXP consists of 4567 samples from 2863 healthy individuals gathered from existing public databases and our own data, in either microarray or RNA-Seq library types. We mainly provide two analysis results based on the large dataset: (i) basic gene expression across specific brain regions, age ranges and sexes; (ii) co-expression analysis from different platforms.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availability and implementation<\/jats:title>\n                  <jats:p>http:\/\/www.brainexp.org\/<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Supplementary information<\/jats:title>\n                  <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/bty576","type":"journal-article","created":{"date-parts":[[2018,7,6]],"date-time":"2018-07-06T01:07:02Z","timestamp":1530839222000},"page":"172-174","source":"Crossref","is-referenced-by-count":16,"title":["BrainEXP: a database featuring with spatiotemporal expression variations and co-expression organizations in human brains"],"prefix":"10.1093","volume":"35","author":[{"given":"Chuan","family":"Jiao","sequence":"first","affiliation":[{"name":"Center for Medical Genetics, School of Life Science, Central South University, Changsha, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengpeng","family":"Yan","sequence":"additional","affiliation":[{"name":"Hunan Qingpeng International Information Technology, Changsha, China"},{"name":"Qingres Limited, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cuihua","family":"Xia","sequence":"additional","affiliation":[{"name":"Center for Medical Genetics, School of Life Science, Central South University, Changsha, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaoming","family":"Shen","sequence":"additional","affiliation":[{"name":"Hunan Qingpeng International Information Technology, Changsha, 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