{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T00:44:57Z","timestamp":1740185097121,"version":"3.37.3"},"reference-count":9,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2018,7,25]],"date-time":"2018-07-25T00:00:00Z","timestamp":1532476800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Union\u2019s Horizon 2020 Programme","award":["634107"],"award-info":[{"award-number":["634107"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,2,15]]},"abstract":"Abstract<\/jats:title>\n \n Summary<\/jats:title>\n In cancer research, cell-based assays are used to assess cell migration and invasion. The major bottleneck is the lack of automated tools to visualize and analyse the large amounts of biological dose-response data produced. To address this challenge, we have developed an automated and free software package for dose-response analyses, DoRes, which is released as an add-on of the freely available and open-source tool CellMissy, dedicated to the management and analysis of cell migration data. DoRes implements non-linear curve fitting functionality into a robust, user-friendly and flexible software package with the possibility of importing a tabular file or starting from a cell migration experiment. We demonstrate the ability of the software by analysing public dose-response data and a typical cell migration experiment, and show that the extracted dose-response parameters and the calculated statistical values are consistently comparable to those of the widely used, commercial software GraphPad Prism.<\/jats:p>\n <\/jats:sec>\n \n Availability and implementation<\/jats:title>\n The software here presented is a new module in CellMissy, an open-source and cross-platform package dedicated to the management, storage and analysis of cell migration data. The new module is written in Java, and inherits the cross-platform support from CellMissy. Source code and binaries are freely available under the Apache2 open-source licence at https:\/\/github.com\/compomics\/cellmissy\/.<\/jats:p>\n <\/jats:sec>\n \n Supplementary information<\/jats:title>\n Supplementary data are available at Bioinformatics online.<\/jats:p>\n <\/jats:sec>","DOI":"10.1093\/bioinformatics\/bty634","type":"journal-article","created":{"date-parts":[[2018,7,24]],"date-time":"2018-07-24T22:37:59Z","timestamp":1532471879000},"page":"696-697","source":"Crossref","is-referenced-by-count":1,"title":["DoRes within CellMissy: dose-response analysis on cell migration and related data"],"prefix":"10.1093","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9869-3826","authenticated-orcid":false,"given":"Gwendolien","family":"Sergeant","sequence":"first","affiliation":[{"name":"VIB-UGent Center for Medical Biotechnology, Ghent, Belgium"},{"name":"Department of Biochemistry, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lennart","family":"Martens","sequence":"additional","affiliation":[{"name":"VIB-UGent Center for Medical Biotechnology, Ghent, Belgium"},{"name":"Department of Biochemistry, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marleen","family":"Van Troys","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Masuzzo","sequence":"additional","affiliation":[{"name":"VIB-UGent Center for Medical Biotechnology, Ghent, Belgium"},{"name":"Department of Biochemistry, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2018,7,25]]},"reference":[{"key":"2023051511012129800_bty634-B1","first-page":"4","article-title":"The possible effects of the aggregation of the molecules of haemoglobin on its dissociation curves","volume":"40","author":"Hill","year":"1910","journal-title":"J. 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