{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:51:55Z","timestamp":1787241115729,"version":"build-2736575974"},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2018,7,23]],"date-time":"2018-07-23T00:00:00Z","timestamp":1532304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21575151"],"award-info":[{"award-number":["21575151"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Chinese Academy of Sciences Major Facility-based Open Research Program"},{"DOI":"10.13039\/501100018635","name":"Thousand Youth Talents Program","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100018635","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Summary<\/jats:title>\n                    <jats:p>Ion mobility\u2014mass spectrometry (IM-MS) has showed great application potential for lipidomics. However, IM-MS based lipidomics is significantly restricted by the available software for lipid structural identification. Here, we developed a software tool, namely, LipidIMMS Analyzer, to support the accurate identification of lipids in IM-MS. For the first time, the software incorporates a large-scale database covering over 260 000 lipids and four-dimensional structural information for each lipid [i.e. m\/z, retention time (RT), collision cross-section (CCS) and MS\/MS spectra]. Therefore, multi-dimensional information can be readily integrated to support lipid identifications, and significantly improve the coverage and confidence of identification. Currently, the software supports different IM-MS instruments and data acquisition approaches.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Availability and implementation<\/jats:title>\n                    <jats:p>The software is freely available at: http:\/\/imms.zhulab.cn\/LipidIMMS\/.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Supplementary information<\/jats:title>\n                    <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bioinformatics\/bty661","type":"journal-article","created":{"date-parts":[[2018,7,20]],"date-time":"2018-07-20T09:59:58Z","timestamp":1532080798000},"page":"698-700","source":"Crossref","is-referenced-by-count":61,"title":["LipidIMMS Analyzer: integrating multi-dimensional information to support lipid identification in ion mobility\u2014mass spectrometry based lipidomics"],"prefix":"10.1093","volume":"35","author":[{"given":"Zhiwei","family":"Zhou","sequence":"first","affiliation":[{"name":"Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China"},{"name":"University of Chinese Academy of Sciences, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaotao","family":"Shen","sequence":"additional","affiliation":[{"name":"Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China"},{"name":"University of Chinese Academy of Sciences, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Chen","sequence":"additional","affiliation":[{"name":"Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China"},{"name":"University of Chinese Academy of Sciences, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Tu","sequence":"additional","affiliation":[{"name":"Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China"},{"name":"University of Chinese Academy of Sciences, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Xiong","sequence":"additional","affiliation":[{"name":"Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng-Jiang","family":"Zhu","sequence":"additional","affiliation":[{"name":"Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,7,23]]},"reference":[{"key":"2023051511010417200_bty661-B1","doi-asserted-by":"crossref","first-page":"2804","DOI":"10.1093\/bioinformatics\/btt465","article-title":"LC-IMS-MS Feature Finder: detecting multidimensional liquid chromatography, ion mobility and mass spectrometry features in complex datasets","volume":"29","author":"Crowell","year":"2013","journal-title":"Bioinformatics"},{"key":"2023051511010417200_bty661-B2","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1038\/nrendo.2016.98","article-title":"Lipidomics for studying metabolism","volume":"12","author":"Han","year":"2016","journal-title":"Nat. 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Cheminf."},{"key":"2023051511010417200_bty661-B8","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s11306-017-1304-x","article-title":"Absolute quantitative lipidomics reveals lipidome-wide alterations in aging brain","volume":"14","author":"Tu","year":"2018","journal-title":"Metabolomics"},{"key":"2023051511010417200_bty661-B9","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.cbpa.2017.11.009","article-title":"Recent advances in lipid separations and structural elucidation using mass spectrometry combined with ion mobility spectrometry, ion-molecule reactions and fragmentation approaches","volume":"42","author":"Zheng","year":"2018","journal-title":"Curr. Opin. Chem. Biol."},{"key":"2023051511010417200_bty661-B10","doi-asserted-by":"crossref","first-page":"9559","DOI":"10.1021\/acs.analchem.7b02625","article-title":"LipidCCS: prediction of collision cross-section values for lipids with high precision to support ion mobility-mass spectrometry-based lipidomics","volume":"89","author":"Zhou","year":"2017","journal-title":"Anal. Chem."},{"key":"2023051511010417200_bty661-B11","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.cbpa.2017.10.033","article-title":"Advancing the large-scale CCS database for metabolomics and lipidomics at the machine-learning era","volume":"42","author":"Zhou","year":"2018","journal-title":"Curr. Opin. Chem. 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