{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T20:22:14Z","timestamp":1780086134847,"version":"3.54.0"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2018,8,9]],"date-time":"2018-08-09T00:00:00Z","timestamp":1533772800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"National Key Plan for Scientific Research and Development of China","award":["2016YFD0500300"],"award-info":[{"award-number":["2016YFD0500300"]}]},{"name":"National Key Plan for Scientific Research and Development of China","award":["2016YFC1200200"],"award-info":[{"award-number":["2016YFC1200200"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31500126"],"award-info":[{"award-number":["31500126"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31671371"],"award-info":[{"award-number":["31671371"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81730064"],"award-info":[{"award-number":["81730064"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81571985"],"award-info":[{"award-number":["81571985"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U1603126"],"award-info":[{"award-number":["U1603126"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018537","name":"National Science and Technology Major Project","doi-asserted-by":"crossref","award":["2017ZX10202201"],"award-info":[{"award-number":["2017ZX10202201"]}],"id":[{"id":"10.13039\/501100018537","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100005150","name":"Chinese Academy of Medical Sciences","doi-asserted-by":"publisher","award":["2016-I2M-1-005"],"award-info":[{"award-number":["2016-I2M-1-005"]}],"id":[{"id":"10.13039\/501100005150","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Motivation<\/jats:title>\n                    <jats:p>Receptor mediated entry is the first step for viral infection. However, the question of how viruses select receptors remains unanswered.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Here, by manually curating a high-quality database of 268 pairs of mammalian virus\u2013host receptor interaction, which included 128 unique viral species or sub-species and 119 virus receptors, we found the viral receptors are structurally and functionally diverse, yet they had several common features when compared to other cell membrane proteins: more protein domains, higher level of N-glycosylation, higher ratio of self-interaction and more interaction partners, and higher expression in most tissues of the host. This study could deepen our understanding of virus\u2013receptor interaction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Availability and implementation<\/jats:title>\n                    <jats:p>The database of mammalian virus\u2013host receptor interaction is available at http:\/\/www.computationalbiology.cn: 5000\/viralReceptor.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Supplementary information<\/jats:title>\n                    <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bioinformatics\/bty694","type":"journal-article","created":{"date-parts":[[2018,8,8]],"date-time":"2018-08-08T07:09:52Z","timestamp":1533712192000},"page":"723-728","source":"Crossref","is-referenced-by-count":35,"title":["Cell membrane proteins with high N-glycosylation, high expression and multiple interaction partners are preferred by mammalian viruses as receptors"],"prefix":"10.1093","volume":"35","author":[{"given":"Zheng","family":"Zhang","sequence":"first","affiliation":[{"name":"College of Biology, Hunan University, Changsha, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaozhong","family":"Zhu","sequence":"additional","affiliation":[{"name":"College of Biology, Hunan University, Changsha, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjun","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Biology, Hunan University, Changsha, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zena","family":"Cai","sequence":"additional","affiliation":[{"name":"College of Biology, Hunan University, Changsha, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beibei","family":"Xu","sequence":"additional","affiliation":[{"name":"College of Computer Science and Electronic Engineering, Hunan University, Changsha, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiying","family":"Tan","sequence":"additional","affiliation":[{"name":"College of Computer Science and Electronic Engineering, Hunan University, Changsha, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiping","family":"Wu","sequence":"additional","affiliation":[{"name":"Center of System Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China"},{"name":"Suzhou Institute of Systems Medicine, Suzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingyi","family":"Ge","sequence":"additional","affiliation":[{"name":"College of Biology, Hunan University, Changsha, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinhong","family":"Guo","sequence":"additional","affiliation":[{"name":"College of Biology, Hunan University, Changsha, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongyang","family":"Tan","sequence":"additional","affiliation":[{"name":"College of Biology, Hunan University, Changsha, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zanxian","family":"Xia","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Central South University, Changsha, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haizhen","family":"Zhu","sequence":"additional","affiliation":[{"name":"College of Biology, Hunan University, Changsha, China"},{"name":"State Key Laboratory of Chemo\/Biosensing and Chemometrics, Hunan University, Changsha, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taijiao","family":"Jiang","sequence":"additional","affiliation":[{"name":"Center of System Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China"},{"name":"Suzhou Institute of Systems Medicine, Suzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yousong","family":"Peng","sequence":"additional","affiliation":[{"name":"College of Biology, Hunan University, Changsha, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,8,9]]},"reference":[{"key":"2023013107250324900_bty694-B1","doi-asserted-by":"crossref","first-page":"4.","DOI":"10.1016\/j.coviro.2011.12.005","article-title":"Virus entry: old viruses, new receptors","volume":"2","author":"Backovic","year":"2012","journal-title":"Curr. Opin. Virol"},{"key":"2023013107250324900_bty694-B2","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1126\/science.1058613","article-title":"Evolution of cell recognition by viruses","volume":"292","author":"Baranowski","year":"2001","journal-title":"Science"},{"key":"2023013107250324900_bty694-B3","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1038\/cr.2013.108","article-title":"Spiking the MERS-coronavirus receptor","volume":"23","author":"Bosch","year":"2013","journal-title":"Cell Res"},{"key":"2023013107250324900_bty694-B4","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/S0140-6736(13)61492-0","article-title":"Interhuman transmissibility of Middle East respiratory syndrome coronavirus: estimation of pandemic risk","volume":"382","author":"Breban","year":"2013","journal-title":"Lancet"},{"key":"2023013107250324900_bty694-B5","volume-title":"Structure and Physics of Viruses: An Integrated Textbook","author":"Casasnovas","year":"2013"},{"key":"2023013107250324900_bty694-B6","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.virol.2017.04.019","article-title":"Three cysteine residues of SLC52A1, a receptor for the porcine endogenous retrovirus-A (PERV-A), play a critical role in cell surface expression and infectivity","volume":"507","author":"Colon-Moran","year":"2017","journal-title":"Virology"},{"key":"2023013107250324900_bty694-B7","doi-asserted-by":"crossref","DOI":"10.1007\/s00418-016-1526-4","article-title":"Eukaryotic protein glycosylation: a primer for histochemists and cell biologists","volume":"147","author":"Corfield","year":"2017","journal-title":"Histochem. Cell Biol"},{"key":"2023013107250324900_bty694-B8","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/nrmicro817","article-title":"Virus entry: molecular mechanisms and biomedical applications","volume":"2","author":"Dimitrov","year":"2004","journal-title":"Nat. Rev. Microbiol"},{"key":"2023013107250324900_bty694-B9","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.chom.2013.05.005","article-title":"Pathogens use structural mimicry of native host ligands as a mechanism for host receptor engagement","volume":"14","author":"Drayman","year":"2013","journal-title":"Cell Host Microbe"},{"key":"2023013107250324900_bty694-B10","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1592\/phco.23.3.339.32099","article-title":"Pleconaril, a novel antipicornaviral agent","volume":"23","author":"Florea","year":"2003","journal-title":"Pharmacotherapy"},{"key":"2023013107250324900_bty694-B11","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/nature12711","article-title":"Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor","volume":"503","author":"Ge","year":"2013","journal-title":"Nature"},{"key":"2023013107250324900_bty694-B12","doi-asserted-by":"crossref","first-page":"4170","DOI":"10.1073\/pnas.1521582113","article-title":"Virological factors that increase the transmissibility of emerging human viruses","volume":"113","author":"Geoghegan","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2023013107250324900_bty694-B13","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1083\/jcb.201108131","article-title":"The cell biology of receptor-mediated virus entry","volume":"195","author":"Grove","year":"2011","journal-title":"J. Cell Biol"},{"key":"2023013107250324900_bty694-B14","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1310\/979L-39QP-NC9G-WFTF","article-title":"Human immunodeficiency virus (HIV) entry inhibitors (CCR5 specific blockers) in development: are they the next novel therapies?","volume":"6","author":"Idemyor","year":"2005","journal-title":"HIV Clin. Trials"},{"key":"2023013107250324900_bty694-B15","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s10719-006-5435-y","article-title":"Role of sialic acids in rotavirus infection","volume":"23","author":"Isa","year":"2006","journal-title":"Glycoconjugate J"},{"key":"2023013107250324900_bty694-B16","doi-asserted-by":"crossref","first-page":"E2401","DOI":"10.1073\/pnas.1621061114","article-title":"Multiple origins of viral capsid proteins from cellular ancestors","volume":"114","author":"Krupovic","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2023013107250324900_bty694-B17","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1097\/00002030-200303280-00007","article-title":"A phase II clinical study of the long-term safety and antiviral activity of enfuvirtide-based antiretroviral therapy","volume":"17","author":"Lalezari","year":"2003","journal-title":"Aids"},{"key":"2023013107250324900_bty694-B18","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.antiviral.2008.10.009","article-title":"Characteristics of arbidol-resistant mutants of influenza virus: implications for the mechanism of anti-influenza action of arbidol","volume":"81","author":"Leneva","year":"2009","journal-title":"Antiviral Res"},{"key":"2023013107250324900_bty694-B19","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1128\/JVI.02615-14","article-title":"Receptor recognition mechanisms of coronaviruses: a decade of structural studies","volume":"89","author":"Li","year":"2015","journal-title":"J. Virol"},{"key":"2023013107250324900_bty694-B20","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1146\/annurev-cellbio-100814-125241","article-title":"The hepatitis B virus receptor","volume":"31","author":"Li","year":"2015","journal-title":"Annu. Rev. Cell Dev. Biol"},{"key":"2023013107250324900_bty694-B21","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1146\/annurev-virology-110615-042301","article-title":"Structure, function, and evolution of coronavirus spike proteins","volume":"3","author":"Li","year":"2016","journal-title":"Annu. Rev. Virol"},{"key":"2023013107250324900_bty694-B22","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1056\/NEJMoa1411099","article-title":"Ebola Virus Disease in the Democratic Republic of Congo","volume":"371","author":"Maganga","year":"2014","journal-title":"New. Engl. J. Med"},{"key":"2023013107250324900_bty694-B23","doi-asserted-by":"crossref","first-page":"9677","DOI":"10.1128\/JVI.00978-10","article-title":"Role of N-linked glycosylation of the 5-HT2A receptor in JC virus infection","volume":"84","author":"Maginnis","year":"2010","journal-title":"J. Virol"},{"key":"2023013107250324900_bty694-B24","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1111\/cmi.12340","article-title":"Lipid interactions during virus entry and infection","volume":"16","author":"Mazzon","year":"2014","journal-title":"Cell. Microbiol"},{"key":"2023013107250324900_bty694-B25","doi-asserted-by":"crossref","first-page":"1257601.","DOI":"10.1126\/science.1257601","article-title":"Uncovering disease-disease relationships through the incomplete interactome","volume":"347","author":"Menche","year":"2015","journal-title":"Science"},{"key":"2023013107250324900_bty694-B26","doi-asserted-by":"crossref","first-page":"66","DOI":"10.3390\/v8030066","article-title":"Linking virus genomes with host taxonomy","volume":"8","author":"Mihara","year":"2016","journal-title":"Viruses-Basel"},{"key":"2023013107250324900_bty694-B27","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1056\/NEJMoa1600651","article-title":"Zika virus associated with microcephaly","volume":"374","author":"Mlakar","year":"2016","journal-title":"N. Engl. J. Med"},{"key":"2023013107250324900_bty694-B28","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.11785","article-title":"Filovirus receptor NPC1 contributes to species-specific patterns of ebolavirus susceptibility in bats","volume":"4","author":"Ng","year":"2015","journal-title":"eLife"},{"key":"2023013107250324900_bty694-B29","doi-asserted-by":"crossref","first-page":"646.","DOI":"10.1038\/nature22975","article-title":"Host and viral traits predict zoonotic spillover from mammals","volume":"546","author":"Olival","year":"2017","journal-title":"Nature"},{"key":"2023013107250324900_bty694-B30","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/nature19094","article-title":"Uncovering Earth's virome","volume":"536","author":"Paez-Espino","year":"2016","journal-title":"Nature"},{"key":"2023013107250324900_bty694-B31","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.chom.2016.11.004","article-title":"Recent H3N2 viruses have evolved specificity for extended, branched human-type receptors, conferring potential for increased avidity","volume":"21","author":"Peng","year":"2017","journal-title":"Cell Host Microbe"},{"key":"2023013107250324900_bty694-B32","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/nature16465","article-title":"An essential receptor for adeno-associated virus infection","volume":"530","author":"Pillay","year":"2016","journal-title":"Nature"},{"key":"2023013107250324900_bty694-B33","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.virol.2008.04.032","article-title":"Neutralizing antibody and anti-retroviral drug sensitivities of HIV-1 isolates resistant to small molecule CCR5 inhibitors","volume":"377","author":"Pugach","year":"2008","journal-title":"Virology"},{"key":"2023013107250324900_bty694-B34","first-page":"a006841.","article-title":"Origins of HIV and the AIDS Pandemic. Csh.","volume":"1","author":"Sharp","year":"2011","journal-title":"Perspect. Med"},{"key":"2023013107250324900_bty694-B35","doi-asserted-by":"crossref","first-page":"2207","DOI":"10.1021\/jm010528u","article-title":"Structural studies of the resistance of influenza virus neuramindase to inhibitors","volume":"45","author":"Smith","year":"2002","journal-title":"J. Med. Chem"},{"key":"2023013107250324900_bty694-B36","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/S0968-0004(01)02038-2","article-title":"Protein recognition by cell surface receptors: physiological receptors versus virus interactions","volume":"27","author":"Wang","year":"2002","journal-title":"Trends Biochem. Sci"},{"key":"2023013107250324900_bty694-B37","year":"2018"},{"key":"2023013107250324900_bty694-B38","doi-asserted-by":"crossref","first-page":"e00049","DOI":"10.7554\/eLife.00049","article-title":"Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus","volume":"1","author":"Yan","year":"2012","journal-title":"eLife"}],"container-title":["Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/35\/5\/723\/48965848\/bioinformatics_35_5_723.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/35\/5\/723\/48965848\/bioinformatics_35_5_723.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,31]],"date-time":"2023-01-31T05:19:55Z","timestamp":1675142395000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article\/35\/5\/723\/5068594"}},"subtitle":[],"editor":[{"given":"Jonathan","family":"Wren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,8,9]]},"references-count":38,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,3,1]]}},"URL":"https:\/\/doi.org\/10.1093\/bioinformatics\/bty694","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/271171","asserted-by":"object"}]},"ISSN":["1367-4803","1367-4811"],"issn-type":[{"value":"1367-4803","type":"print"},{"value":"1367-4811","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,3,1]]},"published":{"date-parts":[[2018,8,9]]}}}