{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T21:31:30Z","timestamp":1772573490301,"version":"3.50.1"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2018,11,5]],"date-time":"2018-11-05T00:00:00Z","timestamp":1541376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100003500","name":"University of Padova","doi-asserted-by":"publisher","award":["CPDR150813\/15"],"award-info":[{"award-number":["CPDR150813\/15"]}],"id":[{"id":"10.13039\/501100003500","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Motivation<\/jats:title>\n                  <jats:p>Antibodies are a class of proteins capable of specifically recognizing and binding to a virtually infinite number of antigens. This binding malleability makes them the most valuable category of biopharmaceuticals for both diagnostic and therapeutic applications. The correct identification of the antigen-binding residues in the antibody is crucial for all antibody design and engineering techniques and could also help to understand the complex antigen binding mechanisms. However, the antibody-binding interface prediction field appears to be still rather underdeveloped.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We present a novel method for antibody interface prediction from their experimentally solved structures based on 3D Zernike Descriptors. Roto-translationally invariant descriptors are computed from circular patches of the antibody surface enriched with a chosen subset of physico-chemical properties from the AAindex1 amino acid index set, and are used as samples for a binary classification problem. An SVM classifier is used to distinguish interface surface patches from non-interface ones. The proposed method was shown to outperform other antigen-binding interface prediction software.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availability and implementation<\/jats:title>\n                  <jats:p>Linux binaries and Python scripts are available at https:\/\/github.com\/sebastiandaberdaku\/AntibodyInterfacePrediction. The datasets generated and\/or analyzed during the current study are available at https:\/\/doi.org\/10.6084\/m9.figshare.5442229.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Supplementary information<\/jats:title>\n                  <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/bty918","type":"journal-article","created":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T20:54:42Z","timestamp":1541105682000},"page":"1870-1876","source":"Crossref","is-referenced-by-count":92,"title":["Antibody interface prediction with 3D Zernike descriptors and SVM"],"prefix":"10.1093","volume":"35","author":[{"given":"Sebastian","family":"Daberdaku","sequence":"first","affiliation":[{"name":"Department of Comparative Biomedicine and Food Science, University of Padova, Legnaro, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Ferrari","sequence":"additional","affiliation":[{"name":"Department of Information Engineering, University of Padova, Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2018,11,5]]},"reference":[{"key":"2023012713072354800_bty918-B1","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1006\/jmbi.1997.1354","article-title":"Standard conformations for the canonical structures of immunoglobulins","volume":"273","author":"Al-Lazikani","year":"1997","journal-title":"J. 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