{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T11:10:55Z","timestamp":1770981055167,"version":"3.50.1"},"reference-count":7,"publisher":"Oxford University Press (OUP)","issue":"14","license":[{"start":{"date-parts":[[2018,12,4]],"date-time":"2018-12-04T00:00:00Z","timestamp":1543881600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000025","name":"US National Institute of Mental Health","doi-asserted-by":"crossref","award":["U01 MH109528"],"award-info":[{"award-number":["U01 MH109528"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100012176","name":"Maudsley Charity","doi-asserted-by":"publisher","award":["980"],"award-info":[{"award-number":["980"]}],"id":[{"id":"10.13039\/100012176","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000380","name":"Guy\u2019s and St Thomas\u2019s Charity","doi-asserted-by":"crossref","award":["STR130505"],"award-info":[{"award-number":["STR130505"]}],"id":[{"id":"10.13039\/501100000380","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Summary<\/jats:title>\n                  <jats:p>Results from hundreds of genome-wide association studies (GWAS) are now freely available and offer a catalogue of the association between phenotypes across medicine with variants in the genome. With the aim of using this data to better understand therapeutic mechanisms, we have developed Drug Targetor, a web interface that allows the generation and exploration of drug\u2013target networks of hundreds of phenotypes using GWAS data. Drug Targetor networks consist of drug and target nodes ordered by genetic association and connected by drug\u2013target or drug\u2013gene relationship. We show that Drug Targetor can help prioritize drugs, targets and drug\u2013target interactions for a specific phenotype based on genetic evidence.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availability and implementation<\/jats:title>\n                  <jats:p>Drug Targetor v1.21 is a web application freely available online at drugtargetor.com and under MIT licence. The source code can be found at https:\/\/github.com\/hagax8\/drugtargetor.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Supplementary information<\/jats:title>\n                  <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/bty982","type":"journal-article","created":{"date-parts":[[2018,12,3]],"date-time":"2018-12-03T07:26:13Z","timestamp":1543821973000},"page":"2515-2517","source":"Crossref","is-referenced-by-count":23,"title":["Drug Targetor: a web interface to investigate the human druggome for over 500 phenotypes"],"prefix":"10.1093","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5540-2707","authenticated-orcid":false,"given":"H\u00e9l\u00e9na A","family":"Gaspar","sequence":"first","affiliation":[{"name":"Institute of Psychiatry, Psychology and Neuroscience, Social, Genetic and Developmental Psychiatry (SGDP) Centre, King\u2019s College London, London, UK"},{"name":"South London and Maudsley National Health Service Trust, National Institute for Health Research Biomedical Research Centre, London, UK"}]},{"given":"Christopher","family":"H\u00fcbel","sequence":"additional","affiliation":[{"name":"Institute of Psychiatry, Psychology and Neuroscience, Social, Genetic and Developmental Psychiatry (SGDP) Centre, King\u2019s College London, London, UK"},{"name":"South London and Maudsley National Health Service Trust, National Institute for Health Research Biomedical Research Centre, London, UK"},{"name":"Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden"}]},{"given":"Gerome","family":"Breen","sequence":"additional","affiliation":[{"name":"Institute of Psychiatry, Psychology and Neuroscience, Social, Genetic and Developmental Psychiatry (SGDP) Centre, King\u2019s College London, London, UK"},{"name":"South London and Maudsley National Health Service Trust, National Institute for Health Research Biomedical Research Centre, London, UK"}]}],"member":"286","published-online":{"date-parts":[[2018,12,4]]},"reference":[{"key":"2023062712310166200_bty982-B1","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1038\/s41467-018-03621-1","article-title":"Exploring the phenotypic consequences of tissue specific gene expression variation inferred from GWAS summary statistics","volume":"9","author":"Barbeira","year":"2018","journal-title":"Nat. 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