{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T21:00:53Z","timestamp":1777064453412,"version":"3.51.4"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"14","license":[{"start":{"date-parts":[[2018,12,3]],"date-time":"2018-12-03T00:00:00Z","timestamp":1543795200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["DBI-1458597"],"award-info":[{"award-number":["DBI-1458597"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["DBI-1458515"],"award-info":[{"award-number":["DBI-1458515"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012050","name":"Noble Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016700","name":"North Central Soybean Research Program","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100016700","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Baker Center for Plant Breeding"},{"name":"USDA-NIFA project"},{"name":"GF Sprague Endowment of the Agronomy Department at Iowa State University"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Summary<\/jats:title>\n                  <jats:p>We present GWASpro, a high-performance web server for the analyses of large-scale genome-wide association studies (GWAS). GWASpro was developed to provide data analyses for large-scale molecular genetic data, coupled with complex replicated experimental designs such as found in plant science investigations and to overcome the steep learning curves of existing GWAS software tools. GWASpro supports building complex design matrices, by which complex experimental designs that may include replications, treatments, locations and times, can be accounted for in the linear mixed model. GWASpro is optimized to handle GWAS data that may consist of up to 10 million markers and 10\u00a0000 samples from replicable lines or hybrids. GWASpro provides an interface that significantly reduces the learning curve for new GWAS investigators.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availability and implementation<\/jats:title>\n                  <jats:p>GWASpro is freely available at https:\/\/bioinfo.noble.org\/GWASPRO.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Supplementary information<\/jats:title>\n                  <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/bty989","type":"journal-article","created":{"date-parts":[[2018,11,30]],"date-time":"2018-11-30T20:11:59Z","timestamp":1543608719000},"page":"2512-2514","source":"Crossref","is-referenced-by-count":22,"title":["GWASpro: a high-performance genome-wide association analysis server"],"prefix":"10.1093","volume":"35","author":[{"given":"Bongsong","family":"Kim","sequence":"first","affiliation":[{"name":"Noble Research Institute, Ardmore, OK, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinbin","family":"Dai","sequence":"additional","affiliation":[{"name":"Noble Research Institute, Ardmore, OK, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenchao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Noble Research Institute, Ardmore, OK, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaohong","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Noble Research Institute, Ardmore, OK, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darlene L","family":"Sanchez","sequence":"additional","affiliation":[{"name":"AgriLife Research Center, Texas A&M University, Beaumont, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"L\u00fcbberstedt","sequence":"additional","affiliation":[{"name":"Department of Agronomy, Iowa State University, Ames, IA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Kang","sequence":"additional","affiliation":[{"name":"Noble Research Institute, Ardmore, OK, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael K","family":"Udvardi","sequence":"additional","affiliation":[{"name":"Noble Research Institute, Ardmore, OK, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William D","family":"Beavis","sequence":"additional","affiliation":[{"name":"Department of Agronomy, Iowa State University, Ames, IA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shizhong","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Botany and Plant Sciences, University of California, Riverside, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3460-5564","authenticated-orcid":false,"given":"Patrick X","family":"Zhao","sequence":"additional","affiliation":[{"name":"Noble Research Institute, Ardmore, OK, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2018,12,3]]},"reference":[{"key":"2023062712313913300_bty989-B1","doi-asserted-by":"crossref","first-page":"2633","DOI":"10.1093\/bioinformatics\/btm308","article-title":"TASSEL: software for association mapping of complex traits in diverse samples","volume":"23","author":"Bradbury","year":"2007","journal-title":"Bioinformatics"},{"key":"2023062712313913300_bty989-B2","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1111\/j.0006-341X.1999.00997.x","article-title":"Genomic control for association studies","volume":"55","author":"Devlin","year":"1999","journal-title":"Biometrics"},{"key":"2023062712313913300_bty989-B3","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1006\/tpbi.2001.1542","article-title":"Genomic control, a new approach to genetic-based association studies","volume":"60","author":"Devlin","year":"2001","journal-title":"Theor. 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