{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T00:45:09Z","timestamp":1740185109198,"version":"3.37.3"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"17","license":[{"start":{"date-parts":[[2019,1,12]],"date-time":"2019-01-12T00:00:00Z","timestamp":1547251200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Senior Research Fellowship of Indian Council of Medical Research","award":["BIC\/11(33)\/2014"],"award-info":[{"award-number":["BIC\/11(33)\/2014"]}]},{"DOI":"10.13039\/501100001332","name":"CSIR","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001332","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001501","name":"UGC","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001501","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NET Fellowship","award":["20-12\/2009(ii)EU-IV"],"award-info":[{"award-number":["20-12\/2009(ii)EU-IV"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Motivation<\/jats:title>\n                  <jats:p>In eukaryotes, palmitoylation drives several essential cellular mechanisms like protein sorting, protein stability and protein\u2013protein interaction. Several amino acids namely Cys, Gly, Ser, Thr and Lys undergo palmitoylation. But very little is known about the amino acid patterns that promote palmitoylation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We deduced presence of statistically significant amino acids around palmitoylation sites and their association with different palmitoylated residues i.e. Cys, Gly and Ser. The results suggest that palmitoylation, irrespective of its target residue, generally occurs at sites where Cys, Leu, Lys, Arg, Ser and Met are abundant. Furthermore, functional properties of the three types of palmitoylated proteins were compared. We observed similar functional behavior of Cys and Gly palmitoylated proteins but proteins with Ser palmitoylation showed distinctiveness from remaining two. Motif-wise functional conservation was also observed in Cys palmitoylated proteins. We also did functional annotation of predicted human palmitoylome.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Supplementary information<\/jats:title>\n                  <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btz003","type":"journal-article","created":{"date-parts":[[2019,1,8]],"date-time":"2019-01-08T17:58:56Z","timestamp":1546970336000},"page":"2887-2890","source":"Crossref","is-referenced-by-count":3,"title":["Identifying residues that determine palmitoylation using association rule mining"],"prefix":"10.1093","volume":"35","author":[{"given":"Bandana","family":"Kumari","sequence":"first","affiliation":[{"name":"University of Delhi South Campus Department of Biophysics, , New Delhi, India"}]},{"given":"Ravindra","family":"Kumar","sequence":"additional","affiliation":[{"name":"University of Delhi South Campus Department of Biophysics, , New Delhi, India"}]},{"given":"Manish","family":"Kumar","sequence":"additional","affiliation":[{"name":"University of Delhi South Campus Department of Biophysics, , New Delhi, India"}]}],"member":"286","published-online":{"date-parts":[[2019,1,12]]},"reference":[{"key":"2023062711301999700_btz003-B1","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1002\/pmic.200700657","article-title":"MAPRes: mining association patterns among preferred amino acid residues in the vicinity of amino acids targeted for post-translational modifications","volume":"8","author":"Ahmad","year":"2008","journal-title":"Proteomics"},{"key":"2023062711301999700_btz003-B2","doi-asserted-by":"crossref","first-page":"2981","DOI":"10.1016\/j.bbamem.2011.07.009","article-title":"Protein palmitoylation and subcellular trafficking","volume":"1808","author":"Aicart-Ramos","year":"2011","journal-title":"Biochim. 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