{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T18:56:58Z","timestamp":1784228218081,"version":"3.55.0"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"16","license":[{"start":{"date-parts":[[2019,1,8]],"date-time":"2019-01-08T00:00:00Z","timestamp":1546905600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Nature Scientific Foundation of China","doi-asserted-by":"crossref","award":["31771471"],"award-info":[{"award-number":["31771471"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Nature Scientific Foundation of China","doi-asserted-by":"crossref","award":["61772119"],"award-info":[{"award-number":["61772119"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Natural Science Foundation for Distinguished Young Scholar of Hebei Province","award":["C2017209244"],"award-info":[{"award-number":["C2017209244"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Motivation<\/jats:title>\n                  <jats:p>DNA N6-methyladenine (6mA) is associated with a wide range of biological processes. Since the distribution of 6mA site in the genome is non-random, accurate identification of 6mA sites is crucial for understanding its biological functions. Although experimental methods have been proposed for this regard, they are still cost-ineffective for detecting 6mA site in genome-wide scope. Therefore, it is desirable to develop computational methods to facilitate the identification of 6mA site.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In this study, a computational method called i6mA-Pred was developed to identify 6mA sites in the rice genome, in which the optimal nucleotide chemical properties obtained by the using feature selection technique were used to encode the DNA sequences. It was observed that the i6mA-Pred yielded an accuracy of 83.13% in the jackknife test. Meanwhile, the performance of i6mA-Pred was also superior to other methods.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availability and implementation<\/jats:title>\n                  <jats:p>A user-friendly web-server, i6mA-Pred is freely accessible at http:\/\/lin-group.cn\/server\/i6mA-Pred.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btz015","type":"journal-article","created":{"date-parts":[[2019,1,5]],"date-time":"2019-01-05T12:08:34Z","timestamp":1546690114000},"page":"2796-2800","source":"Crossref","is-referenced-by-count":201,"title":["i6mA-Pred: identifying DNA N6-methyladenine sites in the rice genome"],"prefix":"10.1093","volume":"35","author":[{"given":"Wei","family":"Chen","sequence":"first","affiliation":[{"name":"Innovative Institute of Chinese Medicine and Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China"},{"name":"Center for Genomics and Computational Biology, School of Life Sciences, North China University of Science and Technology, Tangshan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Lv","sequence":"additional","affiliation":[{"name":"Key Laboratory for Neuro-Information of Ministry of Education, School of Life Science and Technology, Center for Informational Biology, University of Electronic Science and Technology of China, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fulei","family":"Nie","sequence":"additional","affiliation":[{"name":"Center for Genomics and Computational Biology, School of Life Sciences, North China University of Science and Technology, Tangshan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Lin","sequence":"additional","affiliation":[{"name":"Key Laboratory for Neuro-Information of Ministry of Education, School of Life Science and Technology, Center for Informational Biology, University of Electronic Science and Technology of China, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,1,8]]},"reference":[{"key":"2023062708583035000_btz015-B1","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/0092-8674(90)90271-F","article-title":"E. coli oriC and the dnaA gene promoter are sequestered from dam methyltransferase following the passage of the chromosomal replication fork","volume":"62","author":"Campbell","year":"1990","journal-title":"Cell"},{"key":"2023062708583035000_btz015-B2","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1186\/s12859-016-1405-y","article-title":"DeepQA: improving the estimation of single protein model quality with deep belief networks","volume":"17","author":"Cao","year":"2016","journal-title":"BMC Bioinformatics"},{"key":"2023062708583035000_btz015-B3","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.3390\/molecules22101732","article-title":"ProLanGO: protein function prediction using neural machine translation based on a recurrent neural network","volume":"22","author":"Cao","year":"2017","journal-title":"Molecules"},{"key":"2023062708583035000_btz015-B4","doi-asserted-by":"crossref","first-page":"433","DOI":"10.3389\/fgene.2018.00433","article-title":"Classifying included and excluded exons in exon skipping event using histone modifications","volume":"9","author":"Chen","year":"2018","journal-title":"Front. 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