{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T09:34:01Z","timestamp":1768469641097,"version":"3.49.0"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"17","license":[{"start":{"date-parts":[[2019,1,14]],"date-time":"2019-01-14T00:00:00Z","timestamp":1547424000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100005606","name":"Genome Institute of Singapore","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005606","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011186","name":"Institute of Zoology, Chinese Academy of Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011186","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key R&D program of China","doi-asserted-by":"crossref","award":["2018YFC0910400"],"award-info":[{"award-number":["2018YFC0910400"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012166","name":"National Key R&D program of China","doi-asserted-by":"crossref","award":["2018YFC1406902"],"award-info":[{"award-number":["2018YFC1406902"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Summary<\/jats:title>\n                  <jats:p>Simulating realistic clonal dynamics of tumors is an important topic in cancer genomics. Here, we present Phylogeny guided Simulator for Tumor Evolution, a tool that can simulate different types of tumor samples including single sector, multi-sector bulk tumor as well as single-cell tumor data under a wide range of evolutionary trajectories. Phylogeny guided Simulator for Tumor Evolution provides an efficient tool for understanding clonal evolution of cancer.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availability and implementation<\/jats:title>\n                  <jats:p>PSiTE is implemented in Python and is available at https:\/\/github.com\/hchyang\/PSiTE.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Supplementary information<\/jats:title>\n                  <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btz028","type":"journal-article","created":{"date-parts":[[2019,1,9]],"date-time":"2019-01-09T04:12:16Z","timestamp":1547007136000},"page":"3148-3150","source":"Crossref","is-referenced-by-count":7,"title":["PSiTE: a Phylogeny guided Simulator for Tumor Evolution"],"prefix":"10.1093","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5330-4241","authenticated-orcid":false,"given":"Hechuan","family":"Yang","sequence":"first","affiliation":[{"name":"Institute of Zoology, Chinese Academy of Sciences Key Laboratory of Zoological Systematics and Evolution, , Beijing, P.R.China"},{"name":"Human Genetics, Genome Institute of Singapore, A*STAR , Singapore, Singapore"}]},{"given":"Bingxin","family":"Lu","sequence":"additional","affiliation":[{"name":"Human Genetics, Genome Institute of Singapore, A*STAR , Singapore, Singapore"}]},{"given":"Lan Huong","family":"Lai","sequence":"additional","affiliation":[{"name":"Human Genetics, Genome Institute of Singapore, A*STAR , Singapore, Singapore"}]},{"given":"Abner Herbert","family":"Lim","sequence":"additional","affiliation":[{"name":"Human Genetics, Genome Institute of Singapore, A*STAR , Singapore, Singapore"}]},{"given":"Jacob Josiah Santiago","family":"Alvarez","sequence":"additional","affiliation":[{"name":"Human Genetics, Genome Institute of Singapore, A*STAR , Singapore, Singapore"}]},{"given":"Weiwei","family":"Zhai","sequence":"additional","affiliation":[{"name":"Institute of Zoology, Chinese Academy of Sciences Key Laboratory of Zoological Systematics and Evolution, , Beijing, P.R.China"},{"name":"Human Genetics, Genome Institute of Singapore, A*STAR , Singapore, Singapore"},{"name":"National Cancer Centre Singapore , Singapore, Singapore"},{"name":"School of Biological Sciences, Nanyang Technological University , Singapore, Singapore"},{"name":"Center for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences , Kunming, P.R.China"}]}],"member":"286","published-online":{"date-parts":[[2019,1,14]]},"reference":[{"key":"2023062711305933100_btz028-B1","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/nm.3984","article-title":"Pan-cancer analysis of the extent and consequences of intratumor heterogeneity","volume":"22","author":"Andor","year":"2016","journal-title":"Nat. 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