{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T20:34:51Z","timestamp":1772138091820,"version":"3.50.1"},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"18","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004410","name":"EMBO","doi-asserted-by":"publisher","award":["ALTF 212-2016"],"award-info":[{"award-number":["ALTF 212-2016"]}],"id":[{"id":"10.13039\/100004410","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Summary<\/jats:title>\n                    <jats:p>Cellular lineage trees can be derived from single-cell RNA sequencing snapshots of differentiating cells. Currently, only datasets with simple topologies are available. To test and further develop tools for lineage tree reconstruction, we need test datasets with known complex topologies. PROSSTT can simulate scRNA-seq datasets for differentiation processes with lineage trees of any desired complexity, noise level, noise model and size. PROSSTT also provides scripts to quantify the quality of predicted lineage trees.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Availability and implementation<\/jats:title>\n                    <jats:p>https:\/\/github.com\/soedinglab\/prosstt.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Supplementary information<\/jats:title>\n                    <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btz078","type":"journal-article","created":{"date-parts":[[2019,1,31]],"date-time":"2019-01-31T08:02:57Z","timestamp":1548921777000},"page":"3517-3519","source":"Crossref","is-referenced-by-count":55,"title":["PROSSTT: probabilistic simulation of single-cell RNA-seq data for complex differentiation processes"],"prefix":"10.1093","volume":"35","author":[{"given":"Nikolaos","family":"Papadopoulos","sequence":"first","affiliation":[{"name":"Quantitative and Computational Biology, Max Planck Institute for Biophysical Chemistry , G\u00f6ttingen, Germany"}]},{"given":"Parra R","family":"Gonzalo","sequence":"additional","affiliation":[{"name":"Quantitative and Computational Biology, Max Planck Institute for Biophysical Chemistry , G\u00f6ttingen, Germany"}]},{"given":"Johannes","family":"S\u00f6ding","sequence":"additional","affiliation":[{"name":"Quantitative and Computational Biology, Max Planck Institute for Biophysical Chemistry , G\u00f6ttingen, Germany"}]}],"member":"286","published-online":{"date-parts":[[2019,2,1]]},"reference":[{"key":"2023013108064253400_btz078-B1","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1093\/bioinformatics\/btv715","article-title":"destiny: diffusion maps for large-scale single-cell data in R","volume":"32","author":"Angerer","year":"2016","journal-title":"Bioinformatics"},{"key":"2023013108064253400_btz078-B2","article-title":"Multilineage communication regulates human liver bud development from pluripotency","volume-title":"Nature","author":"Camp","year":"2017"},{"key":"2023013108064253400_btz078-B3","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1038\/nmeth.2930","article-title":"Validation of noise models for single-cell transcriptomics","volume":"11","author":"Gr\u00fcn","year":"2014","journal-title":"Nat. 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