{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T13:03:04Z","timestamp":1772542984255,"version":"3.50.1"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"18","license":[{"start":{"date-parts":[[2019,2,5]],"date-time":"2019-02-05T00:00:00Z","timestamp":1549324800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001824","name":"The Czech Science Foundation","doi-asserted-by":"crossref","award":["18-15548S"],"award-info":[{"award-number":["18-15548S"]}],"id":[{"id":"10.13039\/501100001824","id-type":"DOI","asserted-by":"crossref"}]},{"name":"SYMBIT","award":["CZ.02.1.01\/0.0\/0.0\/15_003\/0000477"],"award-info":[{"award-number":["CZ.02.1.01\/0.0\/0.0\/15_003\/0000477"]}]},{"DOI":"10.13039\/501100008530","name":"ERDF","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Motivation<\/jats:title>\n                  <jats:p>Expanding research highlights the importance of guanine quadruplex structures. Therefore, easy-accessible tools for quadruplex analyses in DNA and RNA molecules are important for the scientific community.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We developed a web version of the G4Hunter application. This new web-based server is a platform-independent and user-friendly application for quadruplex analyses. It allows retrieval of gene\/nucleotide sequence entries from NCBI databases and provides complete characterization of localization and quadruplex propensity of quadruplex-forming sequences. The G4Hunter web application includes an interactive graphical data representation with many useful options including visualization, sorting, data storage and export.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availability and implementation<\/jats:title>\n                  <jats:p>G4Hunter web application can be accessed at: http:\/\/bioinformatics.ibp.cz.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Supplementary information<\/jats:title>\n                  <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btz087","type":"journal-article","created":{"date-parts":[[2019,2,4]],"date-time":"2019-02-04T13:24:42Z","timestamp":1549286682000},"page":"3493-3495","source":"Crossref","is-referenced-by-count":209,"title":["G4Hunter web application: a web server for G-quadruplex prediction"],"prefix":"10.1093","volume":"35","author":[{"given":"V\u00e1clav","family":"Br\u00e1zda","sequence":"first","affiliation":[{"name":"Department of biophysical chemistry and molecular oncology, Institute of Biophysics, Academy of Sciences of the Czech Republic, Brno , Czech Republic"}]},{"given":"Jan","family":"Kolomazn\u00edk","sequence":"additional","affiliation":[{"name":"Department of Informatics, Mendel University in Brno , Brno, Czech Republic"}]},{"given":"Ji\u0159\u00ed","family":"L\u00fdsek","sequence":"additional","affiliation":[{"name":"Department of Informatics, Mendel University in Brno , Brno, Czech Republic"}]},{"given":"Martin","family":"Bartas","sequence":"additional","affiliation":[{"name":"Department of biophysical chemistry and molecular oncology, Institute of Biophysics, Academy of Sciences of the Czech Republic, Brno , Czech Republic"},{"name":"Department of Biology and Ecology, Faculty of Science, University of Ostrava , Ostrava, Czech Republic"}]},{"given":"Miroslav","family":"Fojta","sequence":"additional","affiliation":[{"name":"Department of biophysical chemistry and molecular oncology, Institute of Biophysics, Academy of Sciences of the Czech Republic, Brno , Czech Republic"}]},{"given":"Ji\u0159\u00ed","family":"\u0160\u0165astn\u00fd","sequence":"additional","affiliation":[{"name":"Department of Informatics, Mendel University in Brno , Brno, Czech Republic"},{"name":"Brno University of Technology, Technicka 2896\/2, 61969 Brno, Czech Republic"}]},{"given":"Jean-Louis","family":"Mergny","sequence":"additional","affiliation":[{"name":"Department of biophysical chemistry and molecular oncology, Institute of Biophysics, Academy of Sciences of the Czech Republic, Brno , Czech Republic"},{"name":"ARNA Laboratory, Inserm U1212, CNRS UMR5320, IECB, Universit\u00e9 de Bordeaux , Pessac, France"}]}],"member":"286","published-online":{"date-parts":[[2019,2,5]]},"reference":[{"key":"2023013108060151200_btz087-B1","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1093\/nar\/gkw006","article-title":"Re-evaluation of G-quadruplex propensity with G4Hunter","volume":"44","author":"Bedrat","year":"2016","journal-title":"Nucleic Acids Res"},{"key":"2023013108060151200_btz087-B2","doi-asserted-by":"crossref","first-page":"33.","DOI":"10.1186\/1471-2199-12-33","article-title":"Cruciform structures are a common DNA feature important for regulating biological processes","volume":"12","author":"Br\u00e1zda","year":"2011","journal-title":"BMC Mol. 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