{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T20:34:54Z","timestamp":1772138094464,"version":"3.50.1"},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"20","license":[{"start":{"date-parts":[[2019,2,22]],"date-time":"2019-02-22T00:00:00Z","timestamp":1550793600000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003549","name":"Hungarian Scientific Research Fund","doi-asserted-by":"publisher","award":["K119287"],"award-info":[{"award-number":["K119287"]}],"id":[{"id":"10.13039\/501100003549","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003549","name":"Hungarian Scientific Research Fund","doi-asserted-by":"publisher","award":["K125607"],"award-info":[{"award-number":["K125607"]}],"id":[{"id":"10.13039\/501100003549","id-type":"DOI","asserted-by":"publisher"}]},{"name":"\u2018Momentum\u2019 Program of the Hungarian Academy of Sciences","award":["LP2012\/35"],"award-info":[{"award-number":["LP2012\/35"]}]},{"name":"National Research, Development and Innovation Fund of Hungary","award":["FIEK_16\u20131\u20132016\u20130005"],"award-info":[{"award-number":["FIEK_16\u20131\u20132016\u20130005"]}]},{"name":"New National Excellence Programme by the Ministry of Human Resources","award":["\u00daNKP-16\u20132_VBK-016"],"award-info":[{"award-number":["\u00daNKP-16\u20132_VBK-016"]}]},{"name":"New National Excellence Programme by the Ministry of Human Resources","award":["LP2012\/35"],"award-info":[{"award-number":["LP2012\/35"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Motivation<\/jats:title>\n                    <jats:p>Due to their special properties, the structures of transmembrane proteins are extremely hard to determine. Several methods exist to predict the propensity of successful completion of the structure determination process. However, available predictors incorporate data of any kind of proteins, hence they can hardly differentiate between crystallizable and non-crystallizable membrane proteins.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We implemented a web server to simplify running TMCrys prediction method that was developed specifically to separate crystallizable and non-crystallizable membrane proteins.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Availability and implementation<\/jats:title>\n                    <jats:p>http:\/\/tmcrys.enzim.ttk.mta.hu<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Supplementary information<\/jats:title>\n                    <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btz108","type":"journal-article","created":{"date-parts":[[2019,2,19]],"date-time":"2019-02-19T23:16:31Z","timestamp":1550618191000},"page":"4203-4204","source":"Crossref","is-referenced-by-count":4,"title":["The TMCrys server for supporting crystallization of transmembrane proteins"],"prefix":"10.1093","volume":"35","author":[{"given":"Julia K","family":"Varga","sequence":"first","affiliation":[{"name":"Institute of Enzymology, Research Center of Natural Sciences, Hungarian Academy of Sciences \u201cMomentum\u201d Membrane Protein Bioinformatics Research Group, , H Budapest, Hungary"}]},{"given":"G\u00e1bor E","family":"Tusn\u00e1dy","sequence":"additional","affiliation":[{"name":"Institute of Enzymology, Research Center of Natural Sciences, Hungarian Academy of Sciences \u201cMomentum\u201d Membrane Protein Bioinformatics Research Group, , H Budapest, Hungary"}]}],"member":"286","published-online":{"date-parts":[[2019,2,21]]},"reference":[{"key":"2023013108285116200_btz108-B1","doi-asserted-by":"crossref","first-page":"D365","DOI":"10.1093\/nar\/gkn790","article-title":"The protein structure initiative structural genomics knowledgebase","volume":"37","author":"Berman","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"2023013108285116200_btz108-B2","doi-asserted-by":"crossref","first-page":"2860","DOI":"10.1093\/bioinformatics\/bth300","article-title":"TargetDB: a target registration database for structural genomics projects","volume":"20","author":"Chen","year":"2004","journal-title":"Bioinformatics"},{"key":"2023013108285116200_btz108-B3","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s13062-015-0061-x","article-title":"The human transmembrane proteome","volume":"10","author":"Dobson","year":"2015","journal-title":"Biol. 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Drug Discov."},{"key":"2023013108285116200_btz108-B5","doi-asserted-by":"crossref","first-page":"D302","DOI":"10.1093\/nar\/gkj120","article-title":"The RCSB PDB information portal for structural genomics","volume":"34","author":"Kouranov","year":"2006","journal-title":"Nucleic Acids Res."},{"key":"2023013108285116200_btz108-B6","doi-asserted-by":"crossref","first-page":"D524","DOI":"10.1093\/nar\/gks1169","article-title":"PDBTM: Protein Data Bank of transmembrane proteins after 8 years","volume":"41","author":"Kozma","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"2023013108285116200_btz108-B7","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1002\/prot.21605","article-title":"Predicting experimental properties of integral membrane proteins by a naive Bayes approach","volume":"70","author":"Martin-Galiano","year":"2007","journal-title":"Proteins Struct. Funct. 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Biol."},{"key":"2023013108285116200_btz108-B10","doi-asserted-by":"crossref","first-page":"D325","DOI":"10.1093\/nar\/gkw939","article-title":"TSTMP: target selection for structural genomics of human transmembrane proteins","volume":"45","author":"Varga","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"2023013108285116200_btz108-B11","doi-asserted-by":"crossref","DOI":"10.1093\/bioinformatics\/bty342","article-title":"TMCrys: predict propensity of success for transmembrane protein crystallization. Bioinformatics","author":"Varga","year":"2018"},{"key":"2023013108285116200_btz108-B12","doi-asserted-by":"crossref","DOI":"10.1385\/1592598900","volume-title":"The Proteomics Protocols Handbook","author":"Walker","year":"2005"},{"key":"2023013108285116200_btz108-B13","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1093\/bioinformatics\/btv042","article-title":"protr\/ProtrWeb: R package and web server for generating various numerical representation schemes of protein sequences","volume":"31","author":"Xiao","year":"2015","journal-title":"Bioinformatics"}],"container-title":["Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/35\/20\/4203\/48977462\/bioinformatics_35_20_4203.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/35\/20\/4203\/48977462\/bioinformatics_35_20_4203.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,31]],"date-time":"2023-01-31T12:20:36Z","timestamp":1675167636000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article\/35\/20\/4203\/5355054"}},"subtitle":[],"editor":[{"given":"Alfonso","family":"Valencia","sequence":"additional","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2019,2,21]]},"references-count":13,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2019,10,15]]}},"URL":"https:\/\/doi.org\/10.1093\/bioinformatics\/btz108","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/446054","asserted-by":"object"}]},"ISSN":["1367-4803","1367-4811"],"issn-type":[{"value":"1367-4803","type":"print"},{"value":"1367-4811","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,10,15]]},"published":{"date-parts":[[2019,2,21]]}}}