{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T14:38:16Z","timestamp":1775313496640,"version":"3.50.1"},"reference-count":64,"publisher":"Oxford University Press (OUP)","issue":"19","license":[{"start":{"date-parts":[[2019,3,6]],"date-time":"2019-03-06T00:00:00Z","timestamp":1551830400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01 DK089167"],"award-info":[{"award-number":["R01 DK089167"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"NSF","doi-asserted-by":"publisher","award":["213 DBI-0965741"],"award-info":[{"award-number":["213 DBI-0965741"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"NSF","doi-asserted-by":"publisher","award":["R42 GM087013"],"award-info":[{"award-number":["R42 GM087013"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Robert J. Sokol Endowment in Systems Biology"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Motivation<\/jats:title>\n                  <jats:p>Drug repurposing is a potential alternative to the classical drug discovery pipeline. Repurposing involves finding novel indications for already approved drugs. In this work, we present a novel machine learning-based method for drug repurposing. This method explores the anti-similarity between drugs and a disease to uncover new uses for the drugs. More specifically, our proposed method takes into account three sources of information: (i) large-scale gene expression profiles corresponding to human cell lines treated with small molecules, (ii) gene expression profile of a human disease and (iii) the known relationship between Food and Drug Administration (FDA)-approved drugs and diseases. Using these data, our proposed method learns a similarity metric through a supervised machine learning-based algorithm such that a disease and its associated FDA-approved drugs have smaller distance than the other disease-drug pairs.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We validated our framework by showing that the proposed method incorporating distance metric learning technique can retrieve FDA-approved drugs for their approved indications. Once validated, we used our approach to identify a few strong candidates for repurposing.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availability and implementation<\/jats:title>\n                  <jats:p>The R scripts are available on demand from the authors.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Supplementary information<\/jats:title>\n                  <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btz156","type":"journal-article","created":{"date-parts":[[2019,3,4]],"date-time":"2019-03-04T20:15:00Z","timestamp":1551730500000},"page":"3672-3678","source":"Crossref","is-referenced-by-count":42,"title":["A new computational drug repurposing method using established disease\u2013drug pair knowledge"],"prefix":"10.1093","volume":"35","author":[{"given":"Nafiseh","family":"Saberian","sequence":"first","affiliation":[{"name":"Department of Computer Science, Wayne State University , Detroit, MI, USA"}]},{"given":"Azam","family":"Peyvandipour","sequence":"additional","affiliation":[{"name":"Department of Computer Science, Wayne State University , Detroit, MI, USA"}]},{"given":"Michele","family":"Donato","sequence":"additional","affiliation":[{"name":"Department of Computer Science, Wayne State University , Detroit, MI, USA"}]},{"given":"Sahar","family":"Ansari","sequence":"additional","affiliation":[{"name":"Department of Computer Science, Wayne State University , Detroit, MI, USA"}]},{"given":"Sorin","family":"Draghici","sequence":"additional","affiliation":[{"name":"Department of Computer Science, Wayne State University , Detroit, MI, USA"},{"name":"Department of Obstetrics and Gynecology, Wayne State University , Detroit, MI, USA"}]}],"member":"286","published-online":{"date-parts":[[2019,3,6]]},"reference":[{"key":"2023020108350800300_btz156-B1","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1377\/hlthaff.25.2.420","article-title":"Estimating the cost of new drug development: is it really $802 million?","volume":"25","author":"Adams","year":"2006","journal-title":"Health Aff"},{"key":"2023020108350800300_btz156-B2","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1093\/bioinformatics\/btt307","article-title":"Drug\u2013target interaction prediction through domain-tuned network-based inference","volume":"29","author":"Alaimo","year":"2013","journal-title":"Bioinformatics"},{"key":"2023020108350800300_btz156-B3","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1007\/978-1-4939-3572-7_23","article-title":"Recommendation techniques for drug\u2013target interaction prediction and drug repositioning","volume":"1415","author":"Alaimo","year":"2016","journal-title":"Methods Mol. Biol"},{"key":"2023020108350800300_btz156-B4","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/nrd1468","article-title":"Drug repositioning: identifying and developing new uses for existing drugs","volume":"3","author":"Ashburn","year":"2004","journal-title":"Nat. Rev. Drug Discov"},{"key":"2023020108350800300_btz156-B5","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1093\/nar\/30.1.17","article-title":"GenBank","volume":"30","author":"Benson","year":"2002","journal-title":"Nucleic Acids Res"},{"key":"2023020108350800300_btz156-B6","doi-asserted-by":"crossref","first-page":"2294","DOI":"10.1002\/art.27504","article-title":"Mammalian target of rapamycin signaling is crucial for joint destruction in experimental arthritis and is activated in osteoclasts from patients with rheumatoid arthritis","volume":"62","author":"Cejka","year":"2010","journal-title":"Arthritis Rheum"},{"key":"2023020108350800300_btz156-B7","doi-asserted-by":"crossref","first-page":"1.","DOI":"10.1155\/2015\/915124","article-title":"Network-based inference methods for drug repositioning","volume":"2015","author":"Chen","year":"2015","journal-title":"Comput. Math. Methods Med"},{"key":"2023020108350800300_btz156-B8","doi-asserted-by":"crossref","first-page":"e665.","DOI":"10.1038\/cddis.2013.154","article-title":"Sorafenib ameliorates bleomycin-induced pulmonary fibrosis: potential roles in the inhibition of epithelial\u2013mesenchymal transition and fibroblast activation","volume":"4","author":"Chen","year":"2013","journal-title":"Cell Death Dis"},{"key":"2023020108350800300_btz156-B9","doi-asserted-by":"crossref","first-page":"e1002503","DOI":"10.1371\/journal.pcbi.1002503","article-title":"Prediction of drug-target interactions and drug repositioning via network-based inference","volume":"8","author":"Cheng","year":"2012","journal-title":"PLoS Comput. Biol"},{"key":"2023020108350800300_btz156-B10","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1136\/thoraxjnl-2013-204596","article-title":"Heterogeneous gene expression signatures correspond to distinct lung pathologies and biomarkers of disease severity in idiopathic pulmonary fibrosis","volume":"70","author":"DePianto","year":"2015","journal-title":"Thorax"},{"key":"2023020108350800300_btz156-B11","first-page":"172","article-title":"The cost of new drug discovery and development","volume":"4","author":"Dickson","year":"2009","journal-title":"Discov. Med"},{"key":"2023020108350800300_btz156-B12","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0167-6296(02)00126-1","article-title":"The price of innovation: new estimates of drug development costs","volume":"22","author":"DiMasi","year":"2003","journal-title":"J. Health Econ"},{"key":"2023020108350800300_btz156-B13","volume-title":"Statistics and Data Analysis for Microarrays Using R and Bioconductor","author":"Dr\u0103ghici","year":"2011"},{"key":"2023020108350800300_btz156-B14","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1093\/bib\/bbr013","article-title":"Exploiting drug\u2013disease relationships for computational drug repositioning","volume":"12","author":"Dudley","year":"2011","journal-title":"Brief. Bioinform"},{"key":"2023020108350800300_btz156-B15","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1093\/nar\/30.1.207","article-title":"Gene Expression Omnibus: NCBI gene expression and hybridization array data repository","volume":"30","author":"Edgar","year":"2002","journal-title":"Nucleic Acids Res"},{"key":"2023020108350800300_btz156-B16","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1038\/nrd2030","article-title":"Sildenafil: from angina to erectile dysfunction to pulmonary hypertension and beyond","volume":"5","author":"Ghofrani","year":"2006","journal-title":"Nat. Rev. Drug Discov"},{"key":"2023020108350800300_btz156-B17","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1185\/03007998609110424","article-title":"Trimipramine in rheumatoid arthritis: a randomized double-blind trial in relieving pain and joint tenderness","volume":"10","author":"Grant Macfarlane","year":"1986","journal-title":"Curr. Med. Res. Opin"},{"key":"2023020108350800300_btz156-B18","doi-asserted-by":"crossref","first-page":"10331.","DOI":"10.1038\/ncomms10331","article-title":"Network-based in silico drug efficacy screening","volume":"7","author":"Guney","year":"2016","journal-title":"Nat. Commun"},{"key":"2023020108350800300_btz156-B19","doi-asserted-by":"crossref","first-page":"D514","DOI":"10.1093\/nar\/gki033","article-title":"Online Mendelian Inheritance in Man (OMIM), a knowledgebase of human genes and genetic disorders","volume":"33","author":"Hamosh","year":"2005","journal-title":"Nucleic Acids Res"},{"key":"2023020108350800300_btz156-B20","doi-asserted-by":"crossref","first-page":"L1217","DOI":"10.1152\/ajplung.00020.2008","article-title":"EGF receptor tyrosine kinase inhibitors diminish transforming growth factor-\u03b1-induced pulmonary fibrosis","volume":"294","author":"Hardie","year":"2008","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol"},{"key":"2023020108350800300_btz156-B21","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/978-3-642-56420-8_10","volume-title":"Lasers in the Musculoskeletal System","author":"Hendrich","year":"2001"},{"key":"2023020108350800300_btz156-B22","doi-asserted-by":"crossref","first-page":"14621","DOI":"10.1073\/pnas.1000138107","article-title":"Discovery of drug mode of action and drug repositioning from transcriptional responses","volume":"107","author":"Iorio","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2023020108350800300_btz156-B23","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.drudis.2012.07.014","article-title":"Transcriptional data: a new gateway to drug repositioning?","volume":"18","author":"Iorio","year":"2013","journal-title":"Drug Discov. Today"},{"key":"2023020108350800300_btz156-B24","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1093\/biostatistics\/4.2.249","article-title":"Exploration, normalization, and summaries of high density oligonucleotide array probe level data","volume":"4","author":"Irizarry","year":"2003","journal-title":"Biostatistics"},{"key":"2023020108350800300_btz156-B25","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1164\/rccm.200509-1534OC","article-title":"Gefitinib prevents bleomycin-induced lung fibrosis in mice","volume":"174","author":"Ishii","year":"2006","journal-title":"Am. J. Respir. Crit. Care Med"},{"key":"2023020108350800300_btz156-B26","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1145\/582415.582418","article-title":"Cumulated gain-based evaluation of IR techniques","volume":"20","author":"J\u00e4rvelin","year":"2002","journal-title":"ACM Trans. Inf. Syst"},{"key":"2023020108350800300_btz156-B27","volume-title":"Principal Component Analysis","author":"Jolliffe","year":"2002"},{"key":"2023020108350800300_btz156-B28","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/S0140-6736(00)02480-6","article-title":"Efficacy of sirolimus compared with azathioprine for reduction of acute renal allograft rejection: a randomised multicentre study","volume":"356","author":"Kahan","year":"2000","journal-title":"Lancet"},{"key":"2023020108350800300_btz156-B29","doi-asserted-by":"crossref","first-page":"197.","DOI":"10.1038\/nbt1284","article-title":"Relating protein pharmacology by ligand chemistry","volume":"25","author":"Keiser","year":"2007","journal-title":"Nat. Biotechnol"},{"key":"2023020108350800300_btz156-B30","doi-asserted-by":"crossref","first-page":"175.","DOI":"10.1038\/nature08506","article-title":"Predicting new molecular targets for known drugs","volume":"462","author":"Keiser","year":"2009","journal-title":"Nature"},{"key":"2023020108350800300_btz156-B31","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1126\/science.1132939","article-title":"The connectivity map: using gene-expression signatures to connect small molecules, genes, and disease","volume":"313","author":"Lamb","year":"2006","journal-title":"Science"},{"key":"2023020108350800300_btz156-B32","doi-asserted-by":"crossref","first-page":"8.","DOI":"10.1038\/s41540-017-0039-7","article-title":"A diseasome cluster-based drug repurposing of soluble guanylate cyclase activators from smooth muscle relaxation to direct neuroprotection","volume":"4","author":"Langhauser","year":"2018","journal-title":"NPJ Syst. Biol. Appl"},{"key":"2023020108350800300_btz156-B33","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1093\/nar\/gkt1068","article-title":"Drugbank 4.0: shedding new light on drug metabolism","volume":"42","author":"Law","year":"2014","journal-title":"Nucleic Acids Res"},{"key":"2023020108350800300_btz156-B34","article-title":"Testing new drugs for treatment of melanoma patients applying connectivity map database analysis with melanoma gene signatures","author":"Libermann","year":"2012","journal-title":"Technical report"},{"key":"2023020108350800300_btz156-B35","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1093\/bib\/bbx017","article-title":"A review of network-based approaches to drug repositioning","volume":"19","author":"Lotfi Shahreza","year":"2017","journal-title":"Brief. Bioinform"},{"key":"2023020108350800300_btz156-B36","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1016\/S0046-8177(97)90256-2","article-title":"Human DNA topoisomerase II-alpha: a new marker of cell proliferation in invasive breast cancer","volume":"28","author":"Lynch","year":"1997","journal-title":"Hum. Pathol"},{"key":"2023020108350800300_btz156-B37","first-page":"49","article-title":"On the generalized distance in statistics","volume":"2","author":"Mahalanobis","year":"1936","journal-title":"PNIS"},{"key":"2023020108350800300_btz156-B38","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1258\/ebm.2009.009225","article-title":"Effect of prolonged phenytoin administration on rat brain gene expression assessed by DNA microarrays","volume":"235","author":"Mariotti","year":"2010","journal-title":"Exp. Biol. Med"},{"key":"2023020108350800300_btz156-B39","doi-asserted-by":"crossref","first-page":"74.","DOI":"10.1093\/nar\/gnh071","article-title":"Sequence-matched probes produce increased cross-platform consistency and more reproducible biological results in microarray-based gene expression measurements","volume":"32","author":"Mecham","year":"2004","journal-title":"Nucleic Acids Res"},{"key":"2023020108350800300_btz156-B40","doi-asserted-by":"crossref","first-page":"1.","DOI":"10.1186\/1755-8794-4-70","article-title":"Bayesian probit regression model for the diagnosis of pulmonary fibrosis: proof-of-principle","volume":"4","author":"Meltzer","year":"2011","journal-title":"BMC Med. Genomics"},{"key":"2023020108350800300_btz156-B41","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1023\/B:BREA.0000004376.21491.44","article-title":"A potential role for the estrogen-metabolizing cytochrome P450 enzymes in human breast carcinogenesis","volume":"82","author":"Modugno","year":"2003","journal-title":"Breast Cancer Res. Treat"},{"key":"2023020108350800300_btz156-B42","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1038\/nrd2961","article-title":"Lessons from 60 years of pharmaceutical innovation","volume":"8","author":"Munos","year":"2009","journal-title":"Nat. Rev. Drug Discov"},{"key":"2023020108350800300_btz156-B43","doi-asserted-by":"crossref","first-page":"30.","DOI":"10.1186\/1758-2946-5-30","article-title":"Drug repositioning: a machine-learning approach through data integration","volume":"5","author":"Napolitano","year":"2013","journal-title":"J. Cheminform"},{"key":"2023020108350800300_btz156-B44","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.tips.2013.03.004","article-title":"Challenges and opportunities of drug repositioning","volume":"34","author":"Novac","year":"2013","journal-title":"Trends Pharmacol. Sci"},{"key":"2023020108350800300_btz156-B45","author":"Pacini","year":"2013"},{"key":"2023020108350800300_btz156-B46","doi-asserted-by":"crossref","first-page":"18640.","DOI":"10.1371\/journal.pone.0018640","article-title":"Identification of prognostic molecular features in the reactive stroma of human breast and prostate cancer","volume":"6","author":"Planche","year":"2011","journal-title":"PLoS One"},{"key":"2023020108350800300_btz156-B47","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1126\/science.290.5500.2323","article-title":"Nonlinear dimensionality reduction by locally linear embedding","volume":"290","author":"Roweis","year":"2000","journal-title":"Science"},{"key":"2023020108350800300_btz156-B48","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1126\/science.1702904","article-title":"Chemistry and biology of the immunophilins and their immunosuppressive ligands","volume":"251","author":"Schreiber","year":"1991","journal-title":"Science"},{"key":"2023020108350800300_btz156-B49","doi-asserted-by":"crossref","first-page":"727","DOI":"10.7164\/antibiotics.28.727","article-title":"Rapamycin (AY-22, 989), a new antifungal antibiotic. II. Fermentation, isolation and characterization","volume":"28","author":"Sehgal","year":"1975","journal-title":"J. Antibiot"},{"key":"2023020108350800300_btz156-B50","doi-asserted-by":"crossref","first-page":"96ra77","DOI":"10.1126\/scitranslmed.3001318","article-title":"Discovery and preclinical validation of drug indications using compendia of public gene expression data","volume":"3","author":"Sirota","year":"2011","journal-title":"Sci. Transl. Med"},{"key":"2023020108350800300_btz156-B51","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2023020108350800300_btz156-B52","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.drudis.2016.10.008","article-title":"Drug repurposing by integrated literature mining and drug\u2013gene\u2013disease triangulation","volume":"22","author":"Sun","year":"2017","journal-title":"Drug Discov. Today"},{"key":"2023020108350800300_btz156-B53","doi-asserted-by":"crossref","first-page":"e1000662","DOI":"10.1371\/journal.pcbi.1000662","article-title":"Network-based elucidation of human disease similarities reveals common functional modules enriched for pluripotent drug targets","volume":"6","author":"Suthram","year":"2010","journal-title":"PLoS Comput. Biol"},{"key":"2023020108350800300_btz156-B54","author":"Tang","year":"2015"},{"key":"2023020108350800300_btz156-B55","doi-asserted-by":"crossref","first-page":"6803.","DOI":"10.1371\/journal.pone.0006803","article-title":"Transcriptome analysis describing new immunity and defense genes in peripheral blood mononuclear cells of rheumatoid arthritis patients","volume":"4","author":"Teixeira","year":"2009","journal-title":"PLoS One"},{"key":"2023020108350800300_btz156-B56","doi-asserted-by":"crossref","first-page":"61.","DOI":"10.1038\/nature11412","article-title":"Comprehensive molecular portraits of human breast tumours","volume":"490","year":"2012","journal-title":"Nature"},{"key":"2023020108350800300_btz156-B57","doi-asserted-by":"crossref","first-page":"119.","DOI":"10.1358\/dnp.2009.22.2.1303818","article-title":"The value of drug repositioning in the current pharmaceutical market","volume":"22","author":"Tobinick","year":"2009","journal-title":"Drug News and Perspect"},{"key":"2023020108350800300_btz156-B58","first-page":"1385","author":"Torresani","year":"2006"},{"key":"2023020108350800300_btz156-B59","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1152\/physiolgenomics.00004.2010","article-title":"Molecular signatures and new candidates to target the pathogenesis of rheumatoid arthritis","volume":"42A","author":"Ungethuem","year":"2010","journal-title":"Physiol. Genomics"},{"key":"2023020108350800300_btz156-B60","doi-asserted-by":"crossref","first-page":"59.","DOI":"10.1186\/s13195-018-0394-7","article-title":"Alzheimer\u2019s disease master regulators analysis: search for potential molecular targets and drug repositioning candidates","volume":"10","author":"Vargas","year":"2018","journal-title":"Alzheimers Res. Ther"},{"key":"2023020108350800300_btz156-B61","doi-asserted-by":"crossref","first-page":"721","DOI":"10.7164\/antibiotics.28.721","article-title":"Rapamycin (AY-22, 989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle","volume":"28","author":"Vezina","year":"1975","journal-title":"J. Antibiot"},{"key":"2023020108350800300_btz156-B62","first-page":"505","author":"Xing","year":"2002"},{"key":"2023020108350800300_btz156-B63","doi-asserted-by":"crossref","first-page":"37708.","DOI":"10.1371\/journal.pone.0037708","article-title":"The peripheral blood transcriptome identifies the presence and extent of disease in idiopathic pulmonary fibrosis","volume":"7","author":"Yang","year":"2012","journal-title":"PLoS One"},{"key":"2023020108350800300_btz156-B64","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.1002\/ijc.25255","article-title":"The antitumor activity of the fungicide ciclopirox","volume":"127","author":"Zhou","year":"2010","journal-title":"Int. J. Cancer"}],"container-title":["Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/35\/19\/3672\/48975985\/bioinformatics_35_19_3672.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/35\/19\/3672\/48975985\/bioinformatics_35_19_3672.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T19:42:41Z","timestamp":1675280561000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article\/35\/19\/3672\/5370176"}},"subtitle":[],"editor":[{"given":"Janet","family":"Kelso","sequence":"additional","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2019,3,6]]},"references-count":64,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2019,10,1]]}},"URL":"https:\/\/doi.org\/10.1093\/bioinformatics\/btz156","relation":{},"ISSN":["1367-4803","1367-4811"],"issn-type":[{"value":"1367-4803","type":"print"},{"value":"1367-4811","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,10,1]]},"published":{"date-parts":[[2019,3,6]]}}}