{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T16:14:28Z","timestamp":1781280868737,"version":"3.54.1"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"20","license":[{"start":{"date-parts":[[2019,3,12]],"date-time":"2019-03-12T00:00:00Z","timestamp":1552348800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Major Research plan of the National Natural Science Foundation of China","award":["U1435222"],"award-info":[{"award-number":["U1435222"]}]},{"name":"Program of International S&T Cooperation","award":["2014DFB30020"],"award-info":[{"award-number":["2014DFB30020"]}]},{"name":"National High Technology Research and Development Program of China","award":["2015AA020108"],"award-info":[{"award-number":["2015AA020108"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Motivation<\/jats:title>\n                  <jats:p>During development of the mammalian embryo, histone modification H3K4me3 plays an important role in regulating gene expression and exhibits extensive reprograming on the parental genomes. In addition to these dramatic epigenetic changes, certain unchanging regulatory elements are also essential for embryonic development.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Using large-scale H3K4me3 chromatin immunoprecipitation sequencing data, we identified a form of H3K4me3 that was present during all eight stages of the mouse embryo before implantation. This \u2018stable H3K4me3\u2019 was highly accessible and much longer than normal H3K4me3. Moreover, most of the stable H3K4me3 was in the promoter region and was enriched in higher chromatin architecture. Using in-depth analysis, we demonstrated that stable H3K4me3 was related to higher gene expression levels and transcriptional initiation during embryonic development. Furthermore, stable H3K4me3 was much more active in blood tumor cells than in normal blood cells, suggesting a potential mechanism of cancer progression.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Supplementary information<\/jats:title>\n                  <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btz173","type":"journal-article","created":{"date-parts":[[2019,3,11]],"date-time":"2019-03-11T12:09:31Z","timestamp":1552306171000},"page":"3931-3936","source":"Crossref","is-referenced-by-count":32,"title":["Stable H3K4me3 is associated with transcription initiation during early embryo development"],"prefix":"10.1093","volume":"35","author":[{"given":"Xin","family":"Huang","sequence":"first","affiliation":[{"name":"Beijing Institute of Radiation Medicine, Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xudong","family":"Gao","sequence":"additional","affiliation":[{"name":"Beijing Institute of Radiation Medicine, Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanying","family":"Li","sequence":"additional","affiliation":[{"name":"Beijing Institute of Radiation Medicine, Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Jiang","sequence":"additional","affiliation":[{"name":"Beijing Institute of Radiation Medicine, Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruijiang","family":"Li","sequence":"additional","affiliation":[{"name":"Beijing Institute of Radiation Medicine, Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Hong","sequence":"additional","affiliation":[{"name":"Beijing Institute of Radiation Medicine, Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenghui","family":"Zhao","sequence":"additional","affiliation":[{"name":"Beijing Institute of Radiation Medicine, Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingkun","family":"Zhou","sequence":"additional","affiliation":[{"name":"Beijing Institute of Radiation Medicine, Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hebing","family":"Chen","sequence":"additional","affiliation":[{"name":"Beijing Institute of Radiation Medicine, Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaochen","family":"Bo","sequence":"additional","affiliation":[{"name":"Beijing Institute of Radiation Medicine, Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9464-1372","authenticated-orcid":false,"given":"Hao","family":"Li","sequence":"additional","affiliation":[{"name":"Beijing Institute of Radiation Medicine, Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,3,12]]},"reference":[{"key":"2023013108283127700_btz173-B1","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1038\/nrg.2017.57","article-title":"The interplay of epigenetic marks during stem cell differentiation and development","volume":"18","author":"Atlasi","year":"2017","journal-title":"Nat. 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