{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T00:02:33Z","timestamp":1777075353559,"version":"3.51.4"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"20","license":[{"start":{"date-parts":[[2019,3,15]],"date-time":"2019-03-15T00:00:00Z","timestamp":1552608000000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MC_UU_00002\/6"],"award-info":[{"award-number":["MC_UU_00002\/6"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Biometrika Trust"},{"name":"Outlier Research in Business"},{"DOI":"10.13039\/100019615","name":"USC Marshall School of Business","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100019615","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Google Faculty Research"},{"name":"NSF-CAREER","award":["1844481"],"award-info":[{"award-number":["1844481"]}]},{"DOI":"10.13039\/100004325","name":"AstraZeneca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004325","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Summary<\/jats:title>\n                  <jats:p>In many areas of biological research, hypotheses are tested in a sequential manner, without having access to future P-values or even the number of hypotheses to be tested. A key setting where this online hypothesis testing occurs is in the context of publicly available data repositories, where the family of hypotheses to be tested is continually growing as new data is accumulated over time. Recently, Javanmard and Montanari proposed the first procedures that control the FDR for online hypothesis testing. We present an R package, onlineFDR, which implements these procedures and provides wrapper functions to apply them to a historic dataset or a growing data repository.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availability and implementation<\/jats:title>\n                  <jats:p>The R package is freely available through Bioconductor (http:\/\/www.bioconductor.org\/packages\/onlineFDR).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Supplementary information<\/jats:title>\n                  <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btz191","type":"journal-article","created":{"date-parts":[[2019,3,13]],"date-time":"2019-03-13T20:12:44Z","timestamp":1552507964000},"page":"4196-4199","source":"Crossref","is-referenced-by-count":20,"title":["onlineFDR: an R package to control the false discovery rate for growing data repositories"],"prefix":"10.1093","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6207-0416","authenticated-orcid":false,"given":"David S","family":"Robertson","sequence":"first","affiliation":[{"name":"MRC Biostatistics Unit, University of Cambridge , Cambridge, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Wildenhain","sequence":"additional","affiliation":[{"name":"Quantitative Biology, Discovery Sciences, IMED Biotech Unit , AstraZeneca, Cambridge, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adel","family":"Javanmard","sequence":"additional","affiliation":[{"name":"Department of Data Sciences and Operations, University of Southern California , Los Angeles, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natasha A","family":"Karp","sequence":"additional","affiliation":[{"name":"Quantitative Biology, Discovery Sciences, IMED Biotech Unit , AstraZeneca, Cambridge, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,3,14]]},"reference":[{"key":"2023013108284452000_btz191-B1","first-page":"289","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J. R. Stat. Soc. B"},{"key":"2023013108284452000_btz191-B2","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1214\/aos\/1013699998","article-title":"The control of the false discovery rate in multiple testing under dependency","volume":"29","author":"Benjamini","year":"2001","journal-title":"Ann. Stat"},{"key":"2023013108284452000_btz191-B3","doi-asserted-by":"crossref","first-page":"9546","DOI":"10.1073\/pnas.0914005107","article-title":"Independent filtering increases detection power for high-throughput experiments","volume":"107","author":"Bourgon","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2023013108284452000_btz191-B4","doi-asserted-by":"crossref","first-page":"e124.","DOI":"10.1371\/journal.pmed.0020124","article-title":"Why most published research findings are false","volume":"2","author":"Ioannidis","year":"2005","journal-title":"PLoS Med"},{"key":"2023013108284452000_btz191-B5","author":"Javanmard","year":"2015"},{"key":"2023013108284452000_btz191-B6","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1214\/17-AOS1559","article-title":"Online rules for control of false discovery rate and false discovery exceedance","volume":"46","author":"Javanmard","year":"2018","journal-title":"Ann. Stat"},{"key":"2023013108284452000_btz191-B7","doi-asserted-by":"crossref","first-page":"15475","DOI":"10.1038\/ncomms15475","article-title":"Prevalence of sexual dimorphism in mammalian phenotypic traits","volume":"8","author":"Karp","year":"2017","journal-title":"Nat. Commun"},{"key":"2023013108284452000_btz191-B8","first-page":"5650","article-title":"Online control of the false discovery rate with decaying memory","volume":"30","author":"Ramdas","year":"2017","journal-title":"Adv. Neural Inf. Proc. Syst"},{"key":"2023013108284452000_btz191-B9","author":"Robertson","year":"2018"},{"key":"2023013108284452000_btz191-B10","doi-asserted-by":"crossref","first-page":"160095.","DOI":"10.1038\/sdata.2016.95","article-title":"Systematic chemical-genetic and chemical-chemical interaction datasets for prediction of compound synergism","volume":"3","author":"Wildenhain","year":"2016","journal-title":"Sci. Data"}],"container-title":["Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/bioinformatics\/advance-article-pdf\/doi\/10.1093\/bioinformatics\/btz191\/28771738\/btz191.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/35\/20\/4196\/48977311\/bioinformatics_35_20_4196.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/35\/20\/4196\/48977311\/bioinformatics_35_20_4196.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,31]],"date-time":"2023-01-31T17:20:17Z","timestamp":1675185617000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article\/35\/20\/4196\/5380770"}},"subtitle":[],"editor":[{"given":"Jonathan","family":"Wren","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2019,3,14]]},"references-count":10,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2019,10,15]]}},"URL":"https:\/\/doi.org\/10.1093\/bioinformatics\/btz191","relation":{},"ISSN":["1367-4803","1367-4811"],"issn-type":[{"value":"1367-4803","type":"print"},{"value":"1367-4811","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,10,15]]},"published":{"date-parts":[[2019,3,14]]}}}