{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T09:18:02Z","timestamp":1776417482392,"version":"3.51.2"},"reference-count":7,"publisher":"Oxford University Press (OUP)","issue":"20","license":[{"start":{"date-parts":[[2019,3,23]],"date-time":"2019-03-23T00:00:00Z","timestamp":1553299200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Research Grants Council of Hong Kong","award":["HKU 17127014"],"award-info":[{"award-number":["HKU 17127014"]}]},{"name":"General Research Fund","award":["HKU T12-710\/16R"],"award-info":[{"award-number":["HKU T12-710\/16R"]}]},{"name":"Theme-based Research Scheme"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Summary<\/jats:title>\n                  <jats:p>The interaction between tumor and immune system plays a crucial role in both cancer development and treatment response. To facilitate comprehensive investigation of tumor\u2013immune interactions, we have designed a user-friendly web portal TISIDB, which integrated multiple types of data resources in oncoimmunology. First, we manually curated 4176 records from 2530 publications, which reported 988 genes related to anti-tumor immunity. Second, genes associated with the resistance or sensitivity of tumor cells to T cell-mediated killing and immunotherapy were identified by analyzing high-throughput screening and genomic profiling data. Third, associations between any gene and immune features, such as lymphocytes, immunomodulators and chemokines, were pre-calculated for 30 TCGA cancer types. In TISIDB, biologists can cross-check a gene of interest about its role in tumor\u2013immune interactions through literature mining and high-throughput data analysis, and generate testable hypotheses and high quality figures for publication.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availability and implementation<\/jats:title>\n                  <jats:p>http:\/\/cis.hku.hk\/TISIDB<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Supplementary information<\/jats:title>\n                  <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btz210","type":"journal-article","created":{"date-parts":[[2019,3,20]],"date-time":"2019-03-20T12:15:55Z","timestamp":1553084155000},"page":"4200-4202","source":"Crossref","is-referenced-by-count":1820,"title":["TISIDB: an integrated repository portal for tumor\u2013immune system interactions"],"prefix":"10.1093","volume":"35","author":[{"given":"Beibei","family":"Ru","sequence":"first","affiliation":[{"name":"School of Biological Sciences, The University of Hong Kong , Hong Kong, China"}]},{"given":"Ching Ngar","family":"Wong","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, The University of Hong Kong , Hong Kong, China"}]},{"given":"Yin","family":"Tong","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, The University of Hong Kong , Hong Kong, China"}]},{"given":"Jia Yi","family":"Zhong","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, The University of Hong Kong , Hong Kong, China"}]},{"given":"Sophia Shek Wa","family":"Zhong","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, The University of Hong Kong , Hong Kong, China"}]},{"given":"Wai Chung","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, The University of Hong Kong , Hong Kong, China"}]},{"given":"Ka Chi","family":"Chu","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, The University of Hong Kong , Hong Kong, China"}]},{"given":"Choi Yiu","family":"Wong","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, The University of Hong Kong , Hong Kong, China"}]},{"given":"Chit Ying","family":"Lau","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, The University of Hong Kong , Hong Kong, China"}]},{"given":"Ian","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, The University of Hong Kong , Hong Kong, China"}]},{"given":"Nam Wai","family":"Chan","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, The University of Hong Kong , Hong Kong, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2911-8446","authenticated-orcid":false,"given":"Jiangwen","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, The University of Hong Kong , Hong Kong, China"}]}],"member":"286","published-online":{"date-parts":[[2019,3,23]]},"reference":[{"key":"2023013108284227800_btz210-B1","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1126\/science.aac9935","article-title":"MYC regulates the antitumor immune response through CD47 and PD-L1","volume":"352","author":"Casey","year":"2016","journal-title":"Science"},{"key":"2023013108284227800_btz210-B2","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1126\/science.aan5951","article-title":"Genomic correlates of response to immune checkpoint therapies in clear cell renal cell carcinoma","volume":"359","author":"Miao","year":"2018","journal-title":"Science"},{"key":"2023013108284227800_btz210-B3","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.coi.2014.01.004","article-title":"New insights into cancer immunoediting and its three component phases\u2013elimination, equilibrium and escape","volume":"27","author":"Mittal","year":"2014","journal-title":"Curr. Opin. 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