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The SICER ChIP-seq caller has proven adept at finding diffuse domains in ChIP-seq data, but it is slow, requires much memory, needs manual installation steps and is hard to use. epic2 is a complete rewrite of SICER that is focused on speed, low memory overhead and ease-of-use.<\/jats:p><\/jats:sec><jats:sec><jats:title>Availability and implementation<\/jats:title><jats:p>The MIT-licensed code is available at https:\/\/github.com\/biocore-ntnu\/epic2.<\/jats:p><\/jats:sec><jats:sec><jats:title>Supplementary information<\/jats:title><jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p><\/jats:sec>","DOI":"10.1093\/bioinformatics\/btz232","type":"journal-article","created":{"date-parts":[[2019,3,26]],"date-time":"2019-03-26T15:13:43Z","timestamp":1553613223000},"page":"4392-4393","source":"Crossref","is-referenced-by-count":167,"title":["epic2 efficiently finds diffuse domains in ChIP-seq data"],"prefix":"10.1093","volume":"35","author":[{"given":"Endre Bakken","family":"Stovner","sequence":"first","affiliation":[{"name":"Department of Computer Science, K.G. Jebsen Center for Genetic Epidemiology, Norwegian University of Science and Technology , Trondheim 7013, Norway"},{"name":"Department of Clinical and Molecular Medicine, K.G. Jebsen Center for Genetic Epidemiology, Norwegian University of Science and Technology , Trondheim 7013, Norway"},{"name":"Bioinformatics Core Facility, K.G. Jebsen Center for Genetic Epidemiology, Norwegian University of Science and Technology , Trondheim 7013, Norway"},{"name":"Department of Public Health and Nursing, K.G. Jebsen Center for Genetic Epidemiology, Norwegian University of Science and Technology , Trondheim 7013, Norway"}]},{"given":"P\u00e5l","family":"S\u00e6trom","sequence":"additional","affiliation":[{"name":"Department of Computer Science, K.G. Jebsen Center for Genetic Epidemiology, Norwegian University of Science and Technology , Trondheim 7013, Norway"},{"name":"Department of Clinical and Molecular Medicine, K.G. 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