{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T21:02:38Z","timestamp":1762376558220,"version":"3.37.3"},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"21","license":[{"start":{"date-parts":[[2019,4,30]],"date-time":"2019-04-30T00:00:00Z","timestamp":1556582400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Summary<\/jats:title>\n                  <jats:p>Although heteroplasmy has been studied extensively in animal systems, there is a lack of tools for analyzing, exploring and visualizing heteroplasmy at the genome-wide level in other taxonomic systems. We introduce icHET, which is a computational workflow that produces an interactive visualization that facilitates the exploration, analysis and discovery of heteroplasmy across multiple genomic samples. icHET works on short reads from multiple samples from any organism with an organellar reference genome (mitochondrial or plastid) and a nuclear reference genome.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availability and implementation<\/jats:title>\n                  <jats:p>The software is available at https:\/\/github.com\/vtphan\/HeteroplasmyWorkflow.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Supplementary information<\/jats:title>\n                  <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btz300","type":"journal-article","created":{"date-parts":[[2019,4,20]],"date-time":"2019-04-20T11:11:23Z","timestamp":1555758683000},"page":"4411-4412","source":"Crossref","is-referenced-by-count":4,"title":["icHET: interactive visualization of cytoplasmic heteroplasmy"],"prefix":"10.1093","volume":"35","author":[{"given":"Vinhthuy","family":"Phan","sequence":"first","affiliation":[{"name":"Department of Computer Science, University of Memphis , Memphis, TN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diem-Trang","family":"Pham","sequence":"additional","affiliation":[{"name":"Department of Computer Science, University of Memphis , Memphis, TN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Melton","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Memphi s, Memphis, TN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam J","family":"Ramsey","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Memphi s, Memphis, TN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Bernie J","family":"Daigle","sequence":"additional","affiliation":[{"name":"Department of Computer Science, University of Memphis , Memphis, TN, USA"},{"name":"Department of Biological Sciences, University of Memphi s, Memphis, TN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3539-2991","authenticated-orcid":false,"given":"Jennifer R","family":"Mandel","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Memphi s, Memphis, TN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,4,30]]},"reference":[{"key":"2023062712480604300_btz300-B1","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/j.1469-8137.2005.01492.x","article-title":"Inheritance and recombination of mitochondrial genomes in plants, fungi and animals","volume":"168","author":"Barr","year":"2005","journal-title":"New Phytol"},{"key":"2023062712480604300_btz300-B2","doi-asserted-by":"crossref","first-page":"3115","DOI":"10.1093\/bioinformatics\/btu483","article-title":"Mtoolbox: a highly automated pipeline for heteroplasmy annotation and prioritization analysis of human mitochondrial variants in high-throughput sequencing","volume":"30","author":"Calabrese","year":"2014","journal-title":"Bioinformatics"},{"key":"2023062712480604300_btz300-B3","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1038\/nature08802","article-title":"Heteroplasmic mitochondrial DNA mutations in normal and tumour cells","volume":"464","author":"He","year":"2010","journal-title":"Nature"},{"key":"2023062712480604300_btz300-B4","first-page":"2.","article-title":"Evolution and inheritance of animal mitochondrial DNA: rules and exceptions","volume":"24","author":"Ladoukakis","year":"2017","journal-title":"J. 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