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In this approach, structures of compounds are considered as the most important features because it is assumed that similar structures will bind to the same target. Therefore, structural analogs of the drugs that bind to the target are selected as drug candidates. However, even though compounds are not structural analogs, they may achieve the desired response. A new drug discovery method based on drug response, which can complement the structure-based methods, is needed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We implemented Siamese neural networks called ReSimNet that take as input two chemical compounds and predicts the CMap score of the two compounds, which we use to measure the transcriptional response similarity of the two compounds. ReSimNet learns the embedding vector of a chemical compound in a transcriptional response space. ReSimNet is trained to minimize the difference between the cosine similarity of the embedding vectors of the two compounds and the CMap score of the two compounds. ReSimNet can find pairs of compounds that are similar in response even though they may have dissimilar structures. In our quantitative evaluation, ReSimNet outperformed the baseline machine learning models. The ReSimNet ensemble model achieves a Pearson correlation of 0.518 and a precision@1% of 0.989. In addition, in the qualitative analysis, we tested ReSimNet on the ZINC15 database and showed that ReSimNet successfully identifies chemical compounds that are relevant to a prototype drug whose mechanism of action is known.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availability and implementation<\/jats:title>\n                  <jats:p>The source code and the pre-trained weights of ReSimNet are available at https:\/\/github.com\/dmis-lab\/ReSimNet.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Supplementary information<\/jats:title>\n                  <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btz411","type":"journal-article","created":{"date-parts":[[2019,5,16]],"date-time":"2019-05-16T11:46:16Z","timestamp":1558007176000},"page":"5249-5256","source":"Crossref","is-referenced-by-count":50,"title":["ReSimNet: drug response similarity prediction using Siamese neural networks"],"prefix":"10.1093","volume":"35","author":[{"given":"Minji","family":"Jeon","sequence":"first","affiliation":[{"name":"Department of Computer Science and Engineering, Korea University , Seoul 02841, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donghyeon","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Computer Science and Engineering, Korea University , Seoul 02841, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinhyuk","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Computer Science and Engineering, Korea University , Seoul 02841, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hwisang","family":"Jeon","sequence":"additional","affiliation":[{"name":"Interdisciplinary Graduate Program in Bioinformatics, Korea University , Seoul 02841, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miyoung","family":"Ko","sequence":"additional","affiliation":[{"name":"Department of Computer Science and Engineering, Korea University , Seoul 02841, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunkyu","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Computer Science and Engineering, Korea University , Seoul 02841, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yonghwa","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Computer Science and Engineering, Korea University , Seoul 02841, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aik-Choon","family":"Tan","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, Department of Medicine, Translational Bioinformatics and Cancer Systems Biology Laboratory, University of Colorado Anschutz Medical Campus , Aurora, CO 12801, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaewoo","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Computer Science and Engineering, Korea University , Seoul 02841, South Korea"},{"name":"Interdisciplinary Graduate Program in Bioinformatics, Korea University , Seoul 02841, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,5,22]]},"reference":[{"key":"2023013108383920500_btz411-B1","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1021\/acscentsci.6b00367","article-title":"Low data drug discovery with one-shot learning","volume":"3","author":"Altae-Tran","year":"2017","journal-title":"ACS Cent. 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