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Recently, we described a detailed study reporting the differences in the type of intermolecular residue\u2013residue contacts between biological and crystallographic interfaces. Our findings allowed us to develop a fast predictor of biological interfaces reaching an accuracy of 0.92 and competitive to the current state of the art. Here we present its web-server implementation, PRODIGY-CRYSTAL, aimed at the classification of biological and crystallographic interfaces. PRODIGY-CRYSTAL has the advantage of being fast, accurate and simple. This, together with its user-friendly interface and user support forum, ensures its broad accessibility.<\/jats:p><\/jats:sec><jats:sec><jats:title>Availability and implementation<\/jats:title><jats:p>PRODIGY-CRYSTAL is freely available without registration requirements at https:\/\/haddock.science.uu.nl\/services\/PRODIGY-CRYSTAL.<\/jats:p><\/jats:sec>","DOI":"10.1093\/bioinformatics\/btz437","type":"journal-article","created":{"date-parts":[[2019,5,25]],"date-time":"2019-05-25T11:09:39Z","timestamp":1558782579000},"page":"4821-4823","source":"Crossref","is-referenced-by-count":50,"title":["PRODIGY-crystal: a web-tool for classification of biological interfaces in protein complexes"],"prefix":"10.1093","volume":"35","author":[{"given":"Brian","family":"Jim\u00e9nez-Garc\u00eda","sequence":"first","affiliation":[{"name":"Computational Structural Biology Group, Bijvoet Center for Biomolecular Research, Faculty of Science - Chemistry, Utrecht University , Utrecht 3512 JE, The Netherlands"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6160-8701","authenticated-orcid":false,"given":"Katarina","family":"Elez","sequence":"additional","affiliation":[{"name":"Computational Structural Biology Group, Bijvoet Center for Biomolecular Research, Faculty of Science - Chemistry, Utrecht University , Utrecht 3512 JE, The Netherlands"}]},{"given":"Panagiotis I","family":"Koukos","sequence":"additional","affiliation":[{"name":"Computational Structural Biology Group, Bijvoet Center for Biomolecular Research, Faculty of Science - Chemistry, Utrecht University , Utrecht 3512 JE, The Netherlands"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7369-1322","authenticated-orcid":false,"given":"Alexandre Mjj","family":"Bonvin","sequence":"additional","affiliation":[{"name":"Computational Structural Biology Group, Bijvoet Center for Biomolecular Research, Faculty of Science - Chemistry, Utrecht University , Utrecht 3512 JE, The Netherlands"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2485-7378","authenticated-orcid":false,"given":"Anna","family":"Vangone","sequence":"additional","affiliation":[{"name":"Computational Structural Biology Group, Bijvoet Center for Biomolecular Research, Faculty of Science - Chemistry, Utrecht University , Utrecht 3512 JE, The Netherlands"}]}],"member":"286","published-online":{"date-parts":[[2019,5,29]]},"reference":[{"key":"2023013108351688900_btz437-B1","doi-asserted-by":"crossref","first-page":"22.","DOI":"10.1186\/s12900-014-0022-0","article-title":"A PDB-wide, evolution- based assessment of protein-protein interfaces","volume":"14","author":"Baskaran","year":"2014","journal-title":"BMC Struct. 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