{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:51:48Z","timestamp":1776214308475,"version":"3.50.1"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"22","license":[{"start":{"date-parts":[[2019,6,14]],"date-time":"2019-06-14T00:00:00Z","timestamp":1560470400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior, Brazil (CAPES) - Finance Code 001","award":["305630\/2016-4"],"award-info":[{"award-number":["305630\/2016-4"]}]},{"DOI":"10.13039\/501100001807","name":"FAPESP","doi-asserted-by":"publisher","award":["2017\/11768-8"],"award-info":[{"award-number":["2017\/11768-8"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Summary<\/jats:title>\n                    <jats:p>iTUPA is a free online application for automatizing the Topographic-Unit Parsimony Analysis (TUPA), which identifies areas of endemism based on topography. iTUPA generates species-occurrences matrices based on user-defined topographic units (TUs) and provides a parsimony analysis of the generated matrix. We tested iTUPA after a proposal of regionalization for the Brazilian Atlantic Forest. iTUPA can handle millions of species registers simultaneously and uses Google Earth high-definition maps to visually explore the endemism data. We believe iTUPA is a useful tool for further discussions on biodiversity conservation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Availability and implementation<\/jats:title>\n                    <jats:p>iTUPA is hosted on Google cloud and freely available at http:\/\/nuvem.ufabc.edu.br\/itupa. iTUPA is implemented using R (version 3.5.1), with RStudio 1.1.453 used as the implementation IDE, Shiny 1.1.0 web framework, and Google Maps\u00ae API version 3.36.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btz487","type":"journal-article","created":{"date-parts":[[2019,6,6]],"date-time":"2019-06-06T15:14:26Z","timestamp":1559834066000},"page":"4818-4820","source":"Crossref","is-referenced-by-count":1,"title":["iTUPA: an online automated application to perform Topographic-Unit Parsimony Analysis"],"prefix":"10.1093","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9460-3085","authenticated-orcid":false,"given":"Muhsen","family":"Hammoud","sequence":"first","affiliation":[{"name":"Center for Mathematics, Computing, and Cognition, Santo Andr\u00e9, S\u00e3o Paulo , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles Morphy D","family":"Santos","sequence":"additional","affiliation":[{"name":"Center for Natural and Human Sciences, Federal University of ABC, Santo Andr\u00e9 , S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o Paulo","family":"Gois","sequence":"additional","affiliation":[{"name":"Center for Mathematics, Computing, and Cognition, Santo Andr\u00e9, S\u00e3o Paulo , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,6,14]]},"reference":[{"key":"2026041420021662600_btz487-B1","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1071\/SB16057","article-title":"Flies, endemicity, and the Atlantic Forest: a biogeographical study using topographic units of analysis","volume":"30","author":"Amorim","year":"2017","journal-title":"Aust. 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