{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T00:22:10Z","timestamp":1781914930687,"version":"3.54.5"},"reference-count":63,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2019,6,20]],"date-time":"2019-06-20T00:00:00Z","timestamp":1560988800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Strategic Priority Research Program of the Chinese Academy of Sciences","award":["XDB13040400"],"award-info":[{"award-number":["XDB13040400"]}]},{"name":"Jilin Provincial Key Laboratory of Big Data Intelligent Computing","award":["20180622002JC"],"award-info":[{"award-number":["20180622002JC"]}]},{"DOI":"10.13039\/501100010211","name":"Education Department of Jilin Province","doi-asserted-by":"publisher","award":["JJKH20180145KJ"],"award-info":[{"award-number":["JJKH20180145KJ"]}],"id":[{"id":"10.13039\/501100010211","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004032","name":"Jilin University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004032","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Bioknow MedAI Institute","award":["BMCPP-2018-001"],"award-info":[{"award-number":["BMCPP-2018-001"]}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Motivation<\/jats:title>\n                  <jats:p>Cell divisions start from replicating the double-stranded DNA, and the DNA replication process needs to be precisely regulated both spatially and temporally. The DNA is replicated starting from the DNA replication origins. A few successful prediction models were generated based on the assumption that the DNA replication origin regions have sequence level features like physicochemical properties significantly different from the other DNA regions.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>This study proposed a feature selection procedure to further refine the classification model of the DNA replication origins. The experimental data demonstrated that as large as 26% improvement in the prediction accuracy may be achieved on the yeast Saccharomyces cerevisiae. Moreover, the prediction accuracies of the DNA replication origins were improved for all the four yeast genomes investigated in this study.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availability and implementation<\/jats:title>\n                  <jats:p>The software sefOri version 1.0 was available at http:\/\/www.healthinformaticslab.org\/supp\/resources.php. An online server was also provided for the convenience of the users, and its web link may be found in the above-mentioned web page.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Supplementary information<\/jats:title>\n                  <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btz506","type":"journal-article","created":{"date-parts":[[2019,6,13]],"date-time":"2019-06-13T19:13:48Z","timestamp":1560453228000},"page":"49-55","source":"Crossref","is-referenced-by-count":10,"title":["sefOri: selecting the best-engineered sequence features to predict DNA replication origins"],"prefix":"10.1093","volume":"36","author":[{"given":"Chenwei","family":"Lou","sequence":"first","affiliation":[{"name":"BioKnow Health Informatics Lab, College of Computer Science and Technology, and Key Laboratory of Symbolic Computation and Knowledge Engineering of Ministry of Education, Jilin University , Changchun 130012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Zhao","sequence":"additional","affiliation":[{"name":"BioKnow Health Informatics Lab, College of Computer Science and Technology, and Key Laboratory of Symbolic Computation and Knowledge Engineering of Ministry of Education, Jilin University , Changchun 130012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruoyao","family":"Shi","sequence":"additional","affiliation":[{"name":"BioKnow Health Informatics Lab, College of Life Sciences, Jilin University , Changchun 130012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Wang","sequence":"additional","affiliation":[{"name":"BioKnow Health Informatics Lab, College of Computer Science and Technology, and Key Laboratory of Symbolic Computation and Knowledge Engineering of Ministry of Education, Jilin University , Changchun 130012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyang","family":"Zhou","sequence":"additional","affiliation":[{"name":"BioKnow Health Informatics Lab, College of Computer Science and Technology, and Key Laboratory of Symbolic Computation and Knowledge Engineering of Ministry of Education, Jilin University , Changchun 130012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yubo","family":"Wang","sequence":"additional","affiliation":[{"name":"BioKnow Health Informatics Lab, College of Computer Science and Technology, and Key Laboratory of Symbolic Computation and Knowledge Engineering of Ministry of Education, Jilin University , Changchun 130012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoqing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathogenobiology, The Key Laboratory of Zoonosis, Chinese Ministry of Education, College of Basic Medicine, Jilin University , Changchun 130012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Huang","sequence":"additional","affiliation":[{"name":"BioKnow Health Informatics Lab, College of Computer Science and Technology, and Key Laboratory of Symbolic Computation and Knowledge Engineering of Ministry of Education, Jilin University , Changchun 130012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Feng","sequence":"additional","affiliation":[{"name":"BioKnow Health Informatics Lab, College of Computer Science and Technology, and Key Laboratory of Symbolic Computation and Knowledge Engineering of Ministry of Education, Jilin University , Changchun 130012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8108-6007","authenticated-orcid":false,"given":"Fengfeng","family":"Zhou","sequence":"additional","affiliation":[{"name":"BioKnow Health Informatics Lab, College of Computer Science and Technology, and Key Laboratory of Symbolic Computation and Knowledge Engineering of Ministry of Education, Jilin University , Changchun 130012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,6,20]]},"reference":[{"key":"2023013109502288300_btz506-B1","doi-asserted-by":"crossref","first-page":"56","DOI":"10.3390\/genes8020056","article-title":"Diversity of DNA replication in the Archaea","volume":"8","author":"Ausiannikava","year":"2017","journal-title":"Genes"},{"key":"2023013109502288300_btz506-B2","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1002\/humu.23185","article-title":"Predicting enhancer activity and variant impact using gkm-SVM","volume":"38","author":"Beer","year":"2017","journal-title":"Hum. Mutat"},{"key":"2023013109502288300_btz506-B3","doi-asserted-by":"crossref","first-page":"D41","DOI":"10.1093\/nar\/gkx1094","article-title":"GenBank","volume":"46","author":"Benson","year":"2018","journal-title":"Nucleic Acids Res"},{"key":"2023013109502288300_btz506-B4","doi-asserted-by":"crossref","first-page":"494","DOI":"10.4161\/cc.4.3.1549","article-title":"Control of ATP-dependent binding of Saccharomyces cerevisiae origin recognition complex to autonomously replicating DNA sequences","volume":"4","author":"Biswas","year":"2005","journal-title":"Cell Cycle"},{"key":"2023013109502288300_btz506-B5","doi-asserted-by":"crossref","first-page":"e114545.","DOI":"10.1371\/journal.pone.0114545","article-title":"Initiation of DNA replication from non-canonical sites on an origin-depleted chromosome","volume":"9","author":"Bogenschutz","year":"2014","journal-title":"PLoS One"},{"key":"2023013109502288300_btz506-B6","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1186\/s12889-018-5026-4","article-title":"App-technology to increase physical activity among patients with diabetes type 2-the DiaCert-study, a randomized controlled trial","volume":"18","author":"Bonn","year":"2018","journal-title":"BMC Public Health"},{"key":"2023013109502288300_btz506-B7","doi-asserted-by":"crossref","first-page":"6523","DOI":"10.1093\/nar\/gkr301","article-title":"High-resolution analysis of four efficient yeast replication origins reveals new insights into the ORC and putative MCM binding elements","volume":"39","author":"Chang","year":"2011","journal-title":"Nucleic Acids Res"},{"key":"2023013109502288300_btz506-B8","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/j.febslet.2012.02.034","article-title":"Prediction of replication origins by calculating DNA structural properties","volume":"586","author":"Chen","year":"2012","journal-title":"FEBS Lett"},{"key":"2023013109502288300_btz506-B9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/bs.enz.2016.03.001","article-title":"Replication initiation in bacteria","volume":"39","author":"Chodavarapu","year":"2016","journal-title":"Enzymes"},{"key":"2023013109502288300_btz506-B10","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.jtbi.2010.12.024","article-title":"Some remarks on protein attribute prediction and pseudo amino acid composition","volume":"273","author":"Chou","year":"2011","journal-title":"J. Theor. Biol"},{"key":"2023013109502288300_btz506-B11","doi-asserted-by":"crossref","first-page":"242","DOI":"10.3390\/genes10030242","article-title":"Prediction of binding hot spots at protein(-)RNA interfaces utilizing extreme gradient boosting","volume":"10","author":"Deng","year":"2019","journal-title":"Genes"},{"key":"2023013109502288300_btz506-B12","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.compbiomed.2018.12.014","article-title":"PLIT: an alignment-free computational tool for identification of long non-coding RNAs in plant transcriptomic datasets","volume":"105","author":"Deshpande","year":"2019","journal-title":"Comput. Biol. Med"},{"key":"2023013109502288300_btz506-B13","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1109\/TNB.2005.853657","article-title":"Multiple SVM-RFE for gene selection in cancer classification with expression data","volume":"4","author":"Duan","year":"2005","journal-title":"IEEE Trans. Nanobiosci"},{"key":"2023013109502288300_btz506-B14","first-page":"e57738","article-title":"Selecting multiple biomarker subsets with similarly effective binary classification performances","volume":"140","author":"Feng","year":"2018","journal-title":"J. Vis. Exp"},{"key":"2023013109502288300_btz506-B15","doi-asserted-by":"crossref","first-page":"3150","DOI":"10.1093\/bioinformatics\/bts565","article-title":"CD-HIT: accelerated for clustering the next-generation sequencing data","volume":"28","author":"Fu","year":"2012","journal-title":"Bioinformatics"},{"key":"2023013109502288300_btz506-B16","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1093\/bioinformatics\/bts151","article-title":"DeOri: a database of eukaryotic DNA replication origins","volume":"28","author":"Gao","year":"2012","journal-title":"Bioinformatics"},{"key":"2023013109502288300_btz506-B17","doi-asserted-by":"crossref","first-page":"79.","DOI":"10.1186\/1471-2105-9-79","article-title":"Ori-Finder: a web-based system for finding oriCs in unannotated bacterial genomes","volume":"9","author":"Gao","year":"2008","journal-title":"BMC Bioinformatics"},{"key":"2023013109502288300_btz506-B18","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1186\/s12859-016-0990-0","article-title":"McTwo: a two-step feature selection algorithm based on maximal information coefficient","volume":"17","author":"Ge","year":"2016","journal-title":"BMC Bioinformatics"},{"key":"2023013109502288300_btz506-B19","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.compbiomed.2018.03.001","article-title":"Investigating the contribution of distance-based features to automatic sleep stage classification","volume":"96","author":"Gharbali","year":"2018","journal-title":"Comput. Biol. Med"},{"key":"2023013109502288300_btz506-B20","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.chemolab.2006.01.007","article-title":"Recursive feature elimination with random forest for PTR-MS analysis of agroindustrial products","volume":"83","author":"Granitto","year":"2006","journal-title":"Chemom. Itell. Lab. Syst"},{"key":"2023013109502288300_btz506-B21","doi-asserted-by":"crossref","first-page":"2286","DOI":"10.1093\/nar\/26.10.2286","article-title":"Analyzing genomes with cumulative skew diagrams","volume":"26","author":"Grigoriev","year":"1998","journal-title":"Nucleic Acids Res"},{"key":"2023013109502288300_btz506-B22","doi-asserted-by":"crossref","first-page":"12516","DOI":"10.1038\/s41598-018-31007-2","article-title":"Prediction of pseudoprogression versus progression using machine learning algorithm in glioblastoma","volume":"8","author":"Jang","year":"2018","journal-title":"Sci. Rep"},{"key":"2023013109502288300_btz506-B23","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1007\/11691730_11","volume-title":"International Workshop on Data Mining for Biomedical Applications, Singapore","author":"Jin","year":"2006"},{"key":"2023013109502288300_btz506-B24","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.compbiomed.2017.10.025","article-title":"CSP-TSM: optimizing the performance of Riemannian tangent space mapping using common spatial pattern for MI-BCI","volume":"91","author":"Kumar","year":"2017","journal-title":"Comput. Biol. Med"},{"key":"2023013109502288300_btz506-B25","doi-asserted-by":"crossref","first-page":"7159","DOI":"10.1128\/MCB.17.12.7159","article-title":"Architecture of the yeast origin recognition complex bound to origins of DNA replication","volume":"17","author":"Lee","year":"1997","journal-title":"Mol. Cell Biol"},{"key":"2023013109502288300_btz506-B26","doi-asserted-by":"crossref","first-page":"a010116.","DOI":"10.1101\/cshperspect.a010116","article-title":"DNA replication origins","volume":"5","author":"Leonard","year":"2013","journal-title":"Cold Spring Harb. Perspect. Biol"},{"key":"2023013109502288300_btz506-B27","doi-asserted-by":"crossref","first-page":"17299","DOI":"10.1038\/s41598-018-35502-4","article-title":"RNAm5Cfinder: a web-server for predicting RNA 5-methylcytosine (m5C) sites based on random forest","volume":"8","author":"Li","year":"2018","journal-title":"Sci. Rep"},{"key":"2023013109502288300_btz506-B28","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.chemolab.2014.12.011","article-title":"iORI-PseKNC: a predictor for identifying origin of replication with pseudo k-tuple nucleotide composition","volume":"141","author":"Li","year":"2015","journal-title":"Chemom. Intel. Lab. Syst"},{"key":"2023013109502288300_btz506-B29","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1093\/bioinformatics\/btl158","article-title":"Cd-hit: a fast program for clustering and comparing large sets of protein or nucleotide sequences","volume":"22","author":"Li","year":"2006","journal-title":"Bioinformatics"},{"key":"2023013109502288300_btz506-B30","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1021\/acs.jproteome.9b00012","article-title":"ELM-MHC: an improved MHC identification method with extreme learning machine algorithm","volume":"18","author":"Li","year":"2019","journal-title":"J. Proteome Res"},{"key":"2023013109502288300_btz506-B31","doi-asserted-by":"crossref","first-page":"e1000946","DOI":"10.1371\/journal.pgen.1000946","article-title":"A comprehensive genome-wide map of autonomously replicating sequences in a naive genome","volume":"6","author":"Liachko","year":"2010","journal-title":"PLoS Genet"},{"key":"2023013109502288300_btz506-B32","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1093\/schbul\/sby091","article-title":"Classification of first-episode schizophrenia using multimodal brain features: a combined structural and diffusion imaging study","volume":"45","author":"Liang","year":"2019","journal-title":"Schizophr. Bull"},{"key":"2023013109502288300_btz506-B33","doi-asserted-by":"crossref","first-page":"13338","DOI":"10.18632\/oncotarget.14524","article-title":"Pse-analysis: a python package for DNA\/RNA and protein\/peptide sequence analysis based on pseudo components and kernel methods","volume":"8","author":"Liu","year":"2017","journal-title":"Oncotarget"},{"key":"2023013109502288300_btz506-B34","doi-asserted-by":"crossref","first-page":"3835","DOI":"10.1093\/bioinformatics\/bty458","article-title":"iEnhancer-EL: identifying enhancers and their strength with ensemble learning approach","volume":"34","author":"Liu","year":"2018","journal-title":"Bioinformatics"},{"key":"2023013109502288300_btz506-B35","doi-asserted-by":"crossref","first-page":"3086","DOI":"10.1093\/bioinformatics\/bty312","article-title":"iRO-3wPseKNC: identify DNA replication origins by three-window-based PseKNC","volume":"34","author":"Liu","year":"2018","journal-title":"Bioinformatics"},{"key":"2023013109502288300_btz506-B36","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1093\/oxfordjournals.molbev.a025626","article-title":"Asymmetric substitution patterns in the two DNA strands of bacteria","volume":"13","author":"Lobry","year":"1996","journal-title":"Mol Biol Evol"},{"key":"2023013109502288300_btz506-B37","doi-asserted-by":"crossref","first-page":"482","DOI":"10.3389\/fmicb.2014.00482","article-title":"Ori-Finder 2, an integrated tool to predict replication origins in the archaeal genomes","volume":"5","author":"Luo","year":"2014","journal-title":"Front. Microbiol"},{"key":"2023013109502288300_btz506-B38","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1126\/science.1536007","article-title":"A yeast chromosomal origin of DNA replication defined by multiple functional elements","volume":"255","author":"Marahrens","year":"1992","journal-title":"Science"},{"key":"2023013109502288300_btz506-B39","doi-asserted-by":"crossref","first-page":"3395","DOI":"10.1002\/j.1460-2075.1994.tb06642.x","article-title":"Replicator dominance in a eukaryotic chromosome","volume":"13","author":"Marahrens","year":"1994","journal-title":"EMBO J"},{"key":"2023013109502288300_btz506-B40","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/nrmicro1640","article-title":"DNA replication initiation: mechanisms and regulation in bacteria","volume":"5","author":"Mott","year":"2007","journal-title":"Nat. Rev. Microbiol"},{"key":"2023013109502288300_btz506-B41","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1101\/gad.385306","article-title":"Genome-wide identification of replication origins in yeast by comparative genomics","volume":"20","author":"Nieduszynski","year":"2006","journal-title":"Genes Dev"},{"key":"2023013109502288300_btz506-B42","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/S0014-5793(03)00263-1","article-title":"Analysis of nucleotide distribution in the genome of Streptomyces coelicolor A3(2) using the Z curve method","volume":"540","author":"Ou","year":"2003","journal-title":"FEBS Lett"},{"key":"2023013109502288300_btz506-B43","doi-asserted-by":"crossref","first-page":"pii: E1779","DOI":"10.3390\/ijms19061779","article-title":"Identification of bacteriophage virion proteins using multinomial naive Bayes with g-gap feature tree","volume":"19","author":"Pan","year":"2018","journal-title":"Int. J. Mol. Sci"},{"key":"2023013109502288300_btz506-B44","doi-asserted-by":"crossref","first-page":"117","DOI":"10.3389\/fmicb.2015.00117","article-title":"Recent advances in the genome-wide study of DNA replication origins in yeast","volume":"6","author":"Peng","year":"2015","journal-title":"Front. Microbiol"},{"key":"2023013109502288300_btz506-B45","doi-asserted-by":"crossref","first-page":"495","DOI":"10.3389\/fgene.2018.00495","article-title":"M6AMRFS: robust prediction of N6-methyladenosine sites with sequence-based features in multiple species","volume":"9","author":"Qiang","year":"2018","journal-title":"Front. Genet"},{"key":"2023013109502288300_btz506-B46","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1534\/g3.113.008565","article-title":"Design and analysis of Bar-seq experiments","volume":"4","author":"Robinson","year":"2014","journal-title":"G3"},{"key":"2023013109502288300_btz506-B47","doi-asserted-by":"crossref","first-page":"533.","DOI":"10.1038\/323533a0","article-title":"Learning representations by back-propagating errors","volume":"323","author":"Rumelhart","year":"1986","journal-title":"Nature"},{"key":"2023013109502288300_btz506-B48","doi-asserted-by":"crossref","first-page":"a012922.","DOI":"10.1101\/cshperspect.a012922","article-title":"Regulating DNA replication in bacteria","volume":"5","author":"Skarstad","year":"2013","journal-title":"Cold Spring Harb. Perspect. Biol"},{"key":"2023013109502288300_btz506-B49","first-page":"220","volume-title":"2018 IEEE 3rd Advanced Information Technology, Electronic and Automation Control Conference (IAEAC) Chongqing, China","author":"Wang","year":"2018"},{"key":"2023013109502288300_btz506-B50","doi-asserted-by":"crossref","first-page":"334","DOI":"10.3390\/ijerph16030334","article-title":"Predicting future driving risk of crash-involved drivers based on a systematic machine learning framework","volume":"16","author":"Wang","year":"2019","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"2023013109502288300_btz506-B51","doi-asserted-by":"crossref","first-page":"21417","DOI":"10.1074\/jbc.M117.815639","article-title":"Replication origin-flanking roadblocks reveal origin-licensing dynamics and altered sequence dependence","volume":"292","author":"Warner","year":"2017","journal-title":"J. Biol. Chem"},{"key":"2023013109502288300_btz506-B52","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1038\/171737a0","article-title":"Molecular structure of nucleic acids; a structure for deoxyribose nucleic acid","volume":"171","author":"Watson","year":"1953","journal-title":"Nature"},{"key":"2023013109502288300_btz506-B53","first-page":"668","author":"Weston","year":"2001"},{"key":"2023013109502288300_btz506-B54","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1073\/pnas.012578499","article-title":"The B2 element of the Saccharomyces cerevisiae ARS1 origin of replication requires specific sequences to facilitate pre-RC formation","volume":"99","author":"Wilmes","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"2023013109502288300_btz506-B55","doi-asserted-by":"crossref","first-page":"34180","DOI":"10.18632\/oncotarget.9057","article-title":"iROS-gPseKNC: predicting replication origin sites in DNA by incorporating dinucleotide position-specific propensity into general pseudo nucleotide composition","volume":"7","author":"Xiao","year":"2016","journal-title":"Oncotarget"},{"key":"2023013109502288300_btz506-B56","doi-asserted-by":"crossref","first-page":"335","DOI":"10.2217\/epi-2017-0097","article-title":"An OMIC biomarker detection algorithm TriVote and its application in methylomic biomarker detection","volume":"10","author":"Xu","year":"2018","journal-title":"Epigenomics"},{"key":"2023013109502288300_btz506-B57","doi-asserted-by":"crossref","first-page":"13013","DOI":"10.1038\/s41598-017-13259-6","article-title":"RIFS: a randomly restarted incremental feature selection algorithm","volume":"7","author":"Ye","year":"2017","journal-title":"Sci. Rep"},{"key":"2023013109502288300_btz506-B58","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1126\/science.1112178","article-title":"Genome-scale identification of nucleosome positions in S. cerevisiae","volume":"309","author":"Yuan","year":"2005","journal-title":"Science"},{"key":"2023013109502288300_btz506-B59","doi-asserted-by":"crossref","first-page":"69783","DOI":"10.18632\/oncotarget.11975","article-title":"iOri-Human: identify human origin of replication by incorporating dinucleotide physicochemical properties into pseudo nucleotide composition","volume":"7","author":"Zhang","year":"2016","journal-title":"Oncotarget"},{"key":"2023013109502288300_btz506-B60","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroscience.2019.05.014","article-title":"Voxel-based morphometry: improving the diagnosis of Alzheimer\u2019s disease based on an extreme learning machine method from the ADNI cohort","author":"Zhang","year":"2019","journal-title":"Neuroscience"},{"key":"2023013109502288300_btz506-B61","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/S0006-291X(02)02214-3","article-title":"Single replication origin of the archaeon Methanosarcina mazei revealed by the Z curve method","volume":"297","author":"Zhang","year":"2002","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"2023013109502288300_btz506-B62","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.compbiomed.2019.01.009","article-title":"Application of supervised machine learning algorithms in the classification of sagittal gait patterns of cerebral palsy children with spastic diplegia","volume":"106","author":"Zhang","year":"2019","journal-title":"Comput. Biol. Med"},{"key":"2023013109502288300_btz506-B63","doi-asserted-by":"crossref","first-page":"3086","DOI":"10.1128\/MCB.20.9.3086-3096.2000","article-title":"Assembly of a complex containing Cdc45p, replication protein A, and Mcm2p at replication origins controlled by S-phase cyclin-dependent kinases and Cdc7p-Dbf4p kinase","volume":"20","author":"Zou","year":"2000","journal-title":"Mol. Cell Biol"}],"container-title":["Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/bioinformatics\/advance-article-pdf\/doi\/10.1093\/bioinformatics\/btz506\/28934876\/btz506.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/36\/1\/49\/48981429\/bioinformatics_36_1_49.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/36\/1\/49\/48981429\/bioinformatics_36_1_49.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,31]],"date-time":"2023-01-31T18:31:23Z","timestamp":1675189883000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article\/36\/1\/49\/5520948"}},"subtitle":[],"editor":[{"given":"John","family":"Hancock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,6,20]]},"references-count":63,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1,1]]}},"URL":"https:\/\/doi.org\/10.1093\/bioinformatics\/btz506","relation":{},"ISSN":["1367-4803","1367-4811"],"issn-type":[{"value":"1367-4803","type":"print"},{"value":"1367-4811","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,1,1]]},"published":{"date-parts":[[2019,6,20]]}}}