{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T02:39:28Z","timestamp":1780540768549,"version":"3.54.1"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2019,7,11]],"date-time":"2019-07-11T00:00:00Z","timestamp":1562803200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"National Key Research Development Program"},{"name":"Hong Kong Scholars Program","award":["2016YFC1200600"],"award-info":[{"award-number":["2016YFC1200600"]}]},{"name":"Hong Kong Scholars Program","award":["2017YFC1200602"],"award-info":[{"award-number":["2017YFC1200602"]}]},{"name":"Hong Kong Scholars Program","award":["2017-037"],"award-info":[{"award-number":["2017-037"]}]},{"name":"Research Grants Council of the Hong Kong Special Administrative Region","award":["T12-710\/16-R"],"award-info":[{"award-number":["T12-710\/16-R"]}]},{"name":"General Research Fund","award":["14203915"],"award-info":[{"award-number":["14203915"]}]},{"name":"General Research Fund","award":["14173817"],"award-info":[{"award-number":["14173817"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Motivation<\/jats:title>\n                  <jats:p>Recent studies have shown that DNA N6-methyladenine (6mA) plays an important role in epigenetic modification of eukaryotic organisms. It has been found that 6mA is closely related to embryonic development, stress response and so on. Developing a new algorithm to quickly and accurately identify 6mA sites in genomes is important for explore their biological functions.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In this paper, we proposed a new classification method called MM-6mAPred based on a Markov model which makes use of the transition probability between adjacent nucleotides to identify 6mA site. The sensitivity and specificity of our method are 89.32% and 90.11%, respectively. The overall accuracy of our method is 89.72%, which is 6.59% higher than that of the previous method i6mA-Pred. It indicated that, compared with the 41 nucleotide chemical properties used by i6mA-Pred, the transition probability between adjacent nucleotides can capture more discriminant sequence information.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availability and implementation<\/jats:title>\n                  <jats:p>The web server of MM-6mAPred is freely accessible at http:\/\/www.insect-genome.com\/MM-6mAPred\/<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Supplementary information<\/jats:title>\n                  <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btz556","type":"journal-article","created":{"date-parts":[[2019,7,9]],"date-time":"2019-07-09T11:11:18Z","timestamp":1562670678000},"page":"388-392","source":"Crossref","is-referenced-by-count":65,"title":["MM-6mAPred: identifying DNA N6-methyladenine sites based on Markov model"],"prefix":"10.1093","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7401-2926","authenticated-orcid":false,"given":"Cong","family":"Pian","sequence":"first","affiliation":[{"name":"Department of Statistics, The Chinese University of Hong Kong , Sha Tin, Hong Kong"},{"name":"State Key Laboratory of Rice Biology and Ministry of Agricultural and Rural Affairs, Key Laboratory of Molecular Biology of Crop Pathogens and Insect Pests , Institute of Insect Sciences, Zhejiang University, Hangzhou 310058, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangle","family":"Zhang","sequence":"additional","affiliation":[{"name":"Binjiang College, Nanjing University of Information Science and Technology , Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Rice Biology and Ministry of Agricultural and Rural Affairs, Key Laboratory of Molecular Biology of Crop Pathogens and Insect Pests , Institute of Insect Sciences, Zhejiang University, Hangzhou 310058, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2744-9030","authenticated-orcid":false,"given":"Xiaodan","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Statistics, The Chinese University of Hong Kong , Sha Tin, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,7,11]]},"reference":[{"key":"2023013112081400500_btz556-B1","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/0022-5193(83)90251-5","article-title":"A Markov analysis of DNA sequences","volume":"104","author":"Almagor","year":"1983","journal-title":"J. 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