{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T20:25:34Z","timestamp":1777321534322,"version":"3.51.4"},"reference-count":7,"publisher":"Oxford University Press (OUP)","issue":"24","license":[{"start":{"date-parts":[[2019,7,22]],"date-time":"2019-07-22T00:00:00Z","timestamp":1563753600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"European Union\u2019s Horizon 2020 program","award":["681002"],"award-info":[{"award-number":["681002"]}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"publisher","award":["NNF14CC0001"],"award-info":[{"award-number":["NNF14CC0001"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"name":"University of Paris Descartes-USPC"},{"DOI":"10.13039\/501100001677","name":"INSERM","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Motivation<\/jats:title>\n                  <jats:p>Adverse outcome pathway (AOP) is a toxicological concept proposed to provide a mechanistic representation of biological perturbation over different layers of biological organization. Although AOPs are by definition chemical-agnostic, many chemical stressors can putatively interfere with one or several AOPs and such information would be relevant for regulatory decision-making.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>With the recent development of AOPs networks aiming to facilitate the identification of interactions among AOPs, we developed a stressor-AOP network (sAOP). Using the \u2018cytotoxitiy burst\u2019 (CTB) approach, we mapped bioactive compounds from the ToxCast data to a list of AOPs reported in AOP-Wiki database. With this analysis, a variety of relevant connections between chemicals and AOP components can be identified suggesting multiple effects not observed in the simplified \u2018one-biological perturbation to one-adverse outcome\u2019 model. The results may assist in the prioritization of chemicals to assess risk-based evaluations in the context of human health.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availability and implementation<\/jats:title>\n                  <jats:p>sAOP is available at http:\/\/saop.cpr.ku.dk<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Supplementary information<\/jats:title>\n                  <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btz570","type":"journal-article","created":{"date-parts":[[2019,7,19]],"date-time":"2019-07-19T11:23:46Z","timestamp":1563535426000},"page":"5391-5392","source":"Crossref","is-referenced-by-count":34,"title":["sAOP: linking chemical stressors to adverse outcomes pathway networks"],"prefix":"10.1093","volume":"35","author":[{"given":"Alejandro","family":"Aguayo-Orozco","sequence":"first","affiliation":[{"name":"Novo Nordisk Foundation Center for Protein Research , Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, DK-2200, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karine","family":"Audouze","sequence":"additional","affiliation":[{"name":"Environmental Toxicity, Therapeutic Targets, Cellular Signaling and Biomarkers (T3S) Unit , Universit\u00e9 de Paris, INSERM UMR-S 1124, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Troels","family":"Siggaard","sequence":"additional","affiliation":[{"name":"Novo Nordisk Foundation Center for Protein Research , Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, DK-2200, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Barouki","sequence":"additional","affiliation":[{"name":"Environmental Toxicity, Therapeutic Targets, Cellular Signaling and Biomarkers (T3S) Unit , Universit\u00e9 de Paris, INSERM UMR-S 1124, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00f8ren","family":"Brunak","sequence":"additional","affiliation":[{"name":"Novo Nordisk Foundation Center for Protein Research , Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, DK-2200, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Taboureau","sequence":"additional","affiliation":[{"name":"Novo Nordisk Foundation Center for Protein Research , Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, DK-2200, Denmark"},{"name":"Universit\u00e9 de Paris, INSERM U1133, Computational Modeling of Protein-Ligand Interactions group, CNRS UMR 8251, Unit of Functional and adaptive Biology, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,7,22]]},"reference":[{"key":"2023013108412702300_btz570-B1","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1002\/etc.34","article-title":"Adverse outcome pathways: a conceptual framework to support ecotoxicology research and risk assessment","volume":"29","author":"Ankley","year":"2010","journal-title":"Environ. 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