{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T23:55:55Z","timestamp":1776297355998,"version":"3.50.1"},"reference-count":8,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2019,8,8]],"date-time":"2019-08-08T00:00:00Z","timestamp":1565222400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100004442","name":"National Science Centre","doi-asserted-by":"crossref","award":["2015\/17\/B\/NZ2\/03689"],"award-info":[{"award-number":["2015\/17\/B\/NZ2\/03689"]}],"id":[{"id":"10.13039\/501100004442","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Science Centre (Poland) Opus","award":["2016\/21\/B\/ST6\/02176"],"award-info":[{"award-number":["2016\/21\/B\/ST6\/02176"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Summary<\/jats:title>\n                  <jats:p>Kr\u00fcppel-associated box domain zinc finger protein (KRAB ZNF) explorer is a web-based tool for comprehensive characterization of the mRNA expression status of KRAB-ZNF transcription factors in the data from The Cancer Genome Atlas study. Key functionalities cover a comparative analysis of KRAB-ZNF expression between normal and cancer tissues, an association of KRAB-ZNF expression with various pathological features, including survival analysis, association with global DNA methylation status, analyses of KRAB-ZNF isoform expressions and analysis of KRAB-ZNF levels in normal tissues.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availability and implementation<\/jats:title>\n                  <jats:p>KRAB ZNF explorer is available at http:\/\/mi2.mini.pw.edu.pl: 8080\/KRAB_ZNF\/. The source code for shiny application is available at: https:\/\/github.com\/MI2DataLab\/KRAB_ZNF\/tree\/master\/app and the source code for analyses and precalculations are available at: https:\/\/github.com\/MI2DataLab\/KRAB_ZNF\/tree\/master\/work<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btz624","type":"journal-article","created":{"date-parts":[[2019,8,6]],"date-time":"2019-08-06T11:14:26Z","timestamp":1565090066000},"page":"980-981","source":"Crossref","is-referenced-by-count":8,"title":["KRAB ZNF explorer\u2014the online tool for the exploration of the transcriptomic profiles of KRAB-ZNF factors in The Cancer Genome Atlas"],"prefix":"10.1093","volume":"36","author":[{"given":"Rafa\u0142","family":"Cylwa","sequence":"first","affiliation":[{"name":"Faculty of Mathematics, Informatics, and Mechanics, University of Warsaw , 02-097 Warsaw, Poland"}]},{"given":"Kornel","family":"Kie\u0142czewski","sequence":"additional","affiliation":[{"name":"Faculty of Mathematics and Information Science, Warsaw University of Technology , 00-662 Warsaw, Poland"}]},{"given":"Marta","family":"Machnik","sequence":"additional","affiliation":[{"name":"Department of Cancer Immunology, Poznan University of Medical Sciences , Poznan 60\u2013408, Poland"},{"name":"Department of Cancer Diagnostics and Immunology, Greater Poland Cancer Centre , Poznan 61\u2013866, Poland"}]},{"given":"Urszula","family":"Oleksiewicz","sequence":"additional","affiliation":[{"name":"Department of Cancer Immunology, Poznan University of Medical Sciences , Poznan 60\u2013408, Poland"},{"name":"Department of Cancer Diagnostics and Immunology, Greater Poland Cancer Centre , Poznan 61\u2013866, Poland"}]},{"given":"Przemys\u0142aw","family":"Biecek","sequence":"additional","affiliation":[{"name":"Faculty of Mathematics, Informatics, and Mechanics, University of Warsaw , 02-097 Warsaw, Poland"},{"name":"Faculty of Mathematics and Information Science, Warsaw University of Technology , 00-662 Warsaw, Poland"}]}],"member":"286","published-online":{"date-parts":[[2019,8,8]]},"reference":[{"key":"2023013110090548400_btz624-B1","doi-asserted-by":"crossref","first-page":"e56721.","DOI":"10.1371\/journal.pone.0056721","article-title":"Global and stage specific patterns of Kruppel-associated-box zinc finger protein gene expression in murine early embryonic cells","volume":"8","author":"Corsinotti","year":"2013","journal-title":"PLoS One"},{"key":"2023013110090548400_btz624-B2","author":"Kassambara","year":"2017"},{"key":"2023013110090548400_btz624-B3","author":"Kosinski","year":"2019"},{"key":"2023013110090548400_btz624-B4","doi-asserted-by":"crossref","first-page":"323.","DOI":"10.1186\/1471-2105-12-323","article-title":"RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome","volume":"12","author":"Li","year":"2011","journal-title":"BMC Bioinformatics"},{"key":"2023013110090548400_btz624-B5","doi-asserted-by":"crossref","first-page":"268","DOI":"10.2174\/13892029113149990002","article-title":"KRAB-zinc finger proteins: a repressor family displaying multiple biological functions","volume":"14","author":"Lupo","year":"2013","journal-title":"Curr. 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