{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T00:45:02Z","timestamp":1740185102219,"version":"3.37.3"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2019,8,8]],"date-time":"2019-08-08T00:00:00Z","timestamp":1565222400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100000268","name":"BBSRC","doi-asserted-by":"publisher","award":["BB\/L011611\/1"],"award-info":[{"award-number":["BB\/L011611\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Summary<\/jats:title>\n                  <jats:p>Comparing genomic features among a large panel of individuals across the same species is considered nowadays a core part of the bioinformatics analyses. This typically involves a series of complex theoretical expressions to compare, intersect, extract symmetric differences between individuals within a large set of genotypes. Several publically available tools are capable of performing such tasks; however, due to the sheer size of variants being queried, such tasks can be computationally expensive with a runtime ranging from few minutes up to several hours depending on the dataset size. This makes existing tools unsuitable for interactive data query or as part of genomic data visualization platforms such as genome browsers. Tersect is a lightweight, high-performance command-line utility which interprets and applies flexible set theoretical expressions to sets of sequence variant data. It can be used both for interactive data exploration and as part of a larger pipeline thanks to its highly optimized storage and indexing algorithms for variant data.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availability and implementation<\/jats:title>\n                  <jats:p>Tersect was implemented in C and released under the MIT license. Tersect is freely available at https:\/\/github.com\/tomkurowski\/tersect.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Supplementary information<\/jats:title>\n                  <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btz634","type":"journal-article","created":{"date-parts":[[2019,8,6]],"date-time":"2019-08-06T19:17:18Z","timestamp":1565119038000},"page":"934-935","source":"Crossref","is-referenced-by-count":6,"title":["Tersect: a set theoretical utility for exploring sequence variant data"],"prefix":"10.1093","volume":"36","author":[{"given":"Tomasz J","family":"Kurowski","sequence":"first","affiliation":[{"name":"The Bioinformatics Group, School of Water, Energy and Environment, Cranfield University , Bedford MK43 0AL, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7880-2519","authenticated-orcid":false,"given":"Fady","family":"Mohareb","sequence":"additional","affiliation":[{"name":"The Bioinformatics Group, School of Water, Energy and Environment, Cranfield University , Bedford MK43 0AL, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,8,8]]},"reference":[{"key":"2023013110075540900_btz634-B1","doi-asserted-by":"crossref","first-page":"2156","DOI":"10.1093\/bioinformatics\/btr330","article-title":"The variant call format and VCFtools","volume":"27","author":"Danecek","year":"2011","journal-title":"Bioinformatics"},{"key":"2023013110075540900_btz634-B2","doi-asserted-by":"crossref","first-page":"e0206636.","DOI":"10.1371\/journal.pone.0206636","article-title":"Exploring natural genetic variation in tomato sucrose synthases on the basis of increased kinetic properties","volume":"13","author":"Dinh","year":"2018","journal-title":"PLoS One"},{"key":"2023013110075540900_btz634-B3","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1038\/s41588-019-0410-2","article-title":"The tomato pan-genome uncovers new genes and a rare allele regulating fruit flavor","volume":"51","author":"Gao","year":"2019","journal-title":"Nat. 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