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We present minimum energy path surface analysis over n-dimensional surfaces (MEPSAnd), an open source GUI-based program that natively calculates minimum energy paths across energy surfaces of any number of dimensions. Among other features, MEPSAnd can compute the path through lowest barriers and automatically provide a set of alternative paths. MEPSAnd offers distinct plotting solutions as well as direct python scripting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Availability and implementation<\/jats:title><jats:p>MEPSAnd is freely available (under GPLv3 license) at: http:\/\/bioweb.cbm.uam.es\/software\/MEPSAnd\/.<\/jats:p><\/jats:sec><jats:sec><jats:title>Supplementary information<\/jats:title><jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p><\/jats:sec>","DOI":"10.1093\/bioinformatics\/btz649","type":"journal-article","created":{"date-parts":[[2019,8,15]],"date-time":"2019-08-15T19:12:48Z","timestamp":1565896368000},"page":"956-958","source":"Crossref","is-referenced-by-count":25,"title":["MEPSAnd: minimum energy path surface analysis over<i>n<\/i>-dimensional surfaces"],"prefix":"10.1093","volume":"36","author":[{"given":"I\u00f1igo","family":"Marcos-Alcalde","sequence":"first","affiliation":[{"name":"Molecular Modelling Group, Centro de Biolog\u00eda Molecular Severo Ochoa, CBMSO (Consejo Superior de Investigaciones Cient\u00edficas\u2013Universidad Aut\u00f3noma de Madrid , CSIC-UAM), Cabrera, CL Nicol\u00e1s 1, E-28049 Madrid, Spain"},{"name":"Biosciences Research Institute, School of Experimental Sciences, Universidad Francisco de Vitoria , UFV, Building E, Ctra. M-515 Pozuelo-Majadahonda Km 1,800, Pozuelo de Alarc\u00f3n, Madrid 28223, Spain"}]},{"given":"Eduardo","family":"L\u00f3pez-Vi\u00f1as","sequence":"additional","affiliation":[{"name":"Biosciences Research Institute, School of Experimental Sciences, Universidad Francisco de Vitoria , UFV, Building E, Ctra. 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