{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T04:24:56Z","timestamp":1786681496386,"version":"3.56.0"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2019,9,6]],"date-time":"2019-09-06T00:00:00Z","timestamp":1567728000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ram\u00f3n y Cajal program","award":["PI13\/01347"],"award-info":[{"award-number":["PI13\/01347"]}]},{"name":"Ministry of Economy, Industry and Competitiveness grant","award":["BFU2016-74975-P"],"award-info":[{"award-number":["BFU2016-74975-P"]}]},{"name":"Asociaci\u00f3n Fundaci\u00f3n Espa\u00f1ola contra el C\u00e1ncer and the Seville University"},{"name":"Sistema Nacional de Garant\u00eda Juvenil and Programa Operativo de Empleo Juvenil"},{"name":"Medical Research Council Skills Development Fellowship","award":["MR\/N014529\/1"],"award-info":[{"award-number":["MR\/N014529\/1"]}]},{"name":"Medical Research Council Fellowship","award":["MR\/L009056\/1"],"award-info":[{"award-number":["MR\/L009056\/1"]}]},{"name":"NSFC International Young Scientist Fellowship","award":["31650110472"],"award-info":[{"award-number":["31650110472"]}]},{"name":"MRC funding to the MRC LMCB University Unit at UCL","award":["MC_U12266B"],"award-info":[{"award-number":["MC_U12266B"]}]},{"name":"Sir Henry Wellcome Fellowship","award":["103095"],"award-info":[{"award-number":["103095"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Summary<\/jats:title>\n                    <jats:p>Here we present EpiGraph, an image analysis tool that quantifies epithelial organization. Our method combines computational geometry and graph theory to measure the degree of order of any packed tissue. EpiGraph goes beyond the traditional polygon distribution analysis, capturing other organizational traits that improve the characterization of epithelia. EpiGraph can objectively compare the rearrangements of epithelial cells during development and homeostasis to quantify how the global ensemble is affected. Importantly, it has been implemented in the open-access platform Fiji. This makes EpiGraph very user friendly, with no programming skills required.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Availability and implementation<\/jats:title>\n                    <jats:p>EpiGraph is available at https:\/\/imagej.net\/EpiGraph and the code is accessible (https:\/\/github.com\/ComplexOrganizationOfLivingMatter\/Epigraph) under GPLv3 license.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Supplementary information<\/jats:title>\n                    <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btz683","type":"journal-article","created":{"date-parts":[[2019,8,29]],"date-time":"2019-08-29T15:28:43Z","timestamp":1567092523000},"page":"1314-1316","source":"Crossref","is-referenced-by-count":14,"title":["EpiGraph: an open-source platform to quantify epithelial organization"],"prefix":"10.1093","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5402-7637","authenticated-orcid":false,"given":"Pablo","family":"Vicente-Munuera","sequence":"first","affiliation":[{"name":"Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Roc\u00edo\/CSIC\/Universidad de Sevilla and Departamento de Biolog\u00eda Celular, Universidad de Sevilla , Seville 41013, Spain"},{"name":"Biomedical Network Research Centre on Neurodegenerative Diseases (CIBERNED) , Madrid 28031, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"G\u00f3mez-G\u00e1lvez","sequence":"additional","affiliation":[{"name":"Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Roc\u00edo\/CSIC\/Universidad de Sevilla and Departamento de Biolog\u00eda Celular, Universidad de Sevilla , Seville 41013, Spain"},{"name":"Biomedical Network Research Centre on Neurodegenerative Diseases (CIBERNED) , Madrid 28031, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J","family":"Tetley","sequence":"additional","affiliation":[{"name":"MRC Laboratory for Molecular Cell Biology, University College London , London WC1E 6BT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Forja","sequence":"additional","affiliation":[{"name":"Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Roc\u00edo\/CSIC\/Universidad de Sevilla and Departamento de Biolog\u00eda Celular, Universidad de Sevilla , Seville 41013, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Tagua","sequence":"additional","affiliation":[{"name":"Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Roc\u00edo\/CSIC\/Universidad de Sevilla and Departamento de Biolog\u00eda Celular, Universidad de Sevilla , Seville 41013, Spain"},{"name":"Biomedical Network Research Centre on Neurodegenerative Diseases (CIBERNED) , Madrid 28031, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Letr\u00e1n","sequence":"additional","affiliation":[{"name":"Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Roc\u00edo\/CSIC\/Universidad de Sevilla and Departamento de Biolog\u00eda Celular, Universidad de Sevilla , Seville 41013, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melda","family":"Tozluoglu","sequence":"additional","affiliation":[{"name":"MRC Laboratory for Molecular Cell Biology, University College London , London WC1E 6BT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanlan","family":"Mao","sequence":"additional","affiliation":[{"name":"MRC Laboratory for Molecular Cell Biology, University College London , London WC1E 6BT, UK"},{"name":"College of Information and Control, Nanjing University of Information Science and Technology , Nanjing, Jiangsu 210044, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8030-1820","authenticated-orcid":false,"given":"Luis M","family":"Escudero","sequence":"additional","affiliation":[{"name":"Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Roc\u00edo\/CSIC\/Universidad de Sevilla and Departamento de Biolog\u00eda Celular, Universidad de Sevilla , Seville 41013, Spain"},{"name":"Biomedical Network Research Centre on Neurodegenerative Diseases (CIBERNED) , Madrid 28031, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,9,6]]},"reference":[{"key":"2023013110133984500_btz683-B1","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1007\/s10618-009-0153-2","article-title":"ECM-aware cell-graph mining for bone tissue modeling and classification","volume":"20","author":"Bilgin","year":"2009","journal-title":"Data Min. 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