{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T13:02:50Z","timestamp":1786194170276,"version":"3.56.0"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2019,10,7]],"date-time":"2019-10-07T00:00:00Z","timestamp":1570406400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"School of Biomedical Sciences, Faculty of Medicine, University of Queensland, Australia"},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["DFG, GRK-1957"],"award-info":[{"award-number":["DFG, GRK-1957"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Motivation<\/jats:title>\n                  <jats:p>A fundamental interest in chronobiology is to compare patterns between groups of rhythmic data. However, many existing methods are ill-equipped to derive statements concerning the statistical significance of differences between rhythms that may be visually apparent. This is attributed to both the form of data used (longitudinal versus cross-sectional) and the limitations of the statistical tests used to draw conclusions.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>To address this problem, we propose that a cosinusoidal curve with a particular parametrization be used to model and compare data of two sets of observations collected over a 24-h period. The novelty of our test is in the parametrization, which allows the explicit estimation of rhythmic parameters [mesor (the rhythm-adjusted mean level of a response variable around which a wave function oscillates), amplitude and phase], and simultaneously testing for statistical significance in all three parameters between two or more groups of datasets. A statistically significant difference between two groups, regarding each of these rhythmic parameters, is indicated by a P-value. The method is evaluated by applying the model to publicly available datasets, and is further exemplified by comparison to the currently recommended method, DODR. The results suggest that the method proposed may be highly sensitive to detect rhythmic differences between groups in phase, amplitude and mesor.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availability and implementation<\/jats:title>\n                  <jats:p>https:\/\/github.com\/RWParsons\/circacompare\/<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btz730","type":"journal-article","created":{"date-parts":[[2019,9,26]],"date-time":"2019-09-26T11:28:48Z","timestamp":1569497328000},"page":"1208-1212","source":"Crossref","is-referenced-by-count":239,"title":["CircaCompare: a method to estimate and statistically support differences in mesor, amplitude and phase, between circadian rhythms"],"prefix":"10.1093","volume":"36","author":[{"given":"Rex","family":"Parsons","sequence":"first","affiliation":[{"name":"School of Biomedical Sciences, Faculty of Medicine, University of Queensland , St Lucia, QLD 4072, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Parsons","sequence":"additional","affiliation":[{"name":"School of Occupational Therapy, Social Work and Speech Pathology , Curtin University, Perth, WA 6845, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Garner","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences, Faculty of Medicine, University of Queensland , St Lucia, QLD 4072, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Oster","sequence":"additional","affiliation":[{"name":"Faculty of Natural Sciences, Institute of Neurobiology, University of L\u00fcbeck , L\u00fcbeck 23562, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7147-4778","authenticated-orcid":false,"given":"Oliver","family":"Rawashdeh","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences, Faculty of Medicine, University of Queensland , St Lucia, QLD 4072, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,10,7]]},"reference":[{"key":"2023013110121329700_btz730-B1","doi-asserted-by":"crossref","first-page":"e0198503","DOI":"10.1371\/journal.pone.0198503","article-title":"A novel mathematical method for disclosing oscillations in gene transcription: a comparative study","volume":"13","author":"Antoulas","year":"2018","journal-title":"PLoS One"},{"key":"2023013110121329700_btz730-B2","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1093\/biostatistics\/kxt020","article-title":"Inference on periodicity of circadian time series","volume":"14","author":"Costa","year":"2013","journal-title":"Biostatistics"},{"key":"2023013110121329700_btz730-B3","first-page":"24","article-title":"The eye: organ of space and time","volume":"249","author":"Douglas","year":"2015","journal-title":"The Optician"},{"key":"2023013110121329700_btz730-B4","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1007\/978-3-642-88394-1_2","volume-title":"The Cellular Aspects of Biorhythms: Symposium on Rhythmic Research Sponsored by the VIIIth International Congress of Anatomy Wiesbaden, 8\u201314. 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