{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:34:12Z","timestamp":1777458852558,"version":"3.51.4"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2019,9,28]],"date-time":"2019-09-28T00:00:00Z","timestamp":1569628800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council UK","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Summary<\/jats:title>\n                  <jats:p>CPLANE is a protein complex required for assembly and maintenance of primary cilia. It contains several proteins, such as INTU, FUZ, WDPCP, JBTS17 and RSG1 (REM2- and RAB-like small GTPase 1), whose genes are mutated in ciliopathies. Using two contrasting evolutionary analyses, coevolution-based contact prediction and sequence conservation, we first identified the INTU\/FUZ heterodimer as a novel member of homologous HerMon (Hermansky-Pudlak syndrome and MON1-CCZ1) complexes. Subsequently, we identified homologous Longin domains that are triplicated in each of these six proteins (MON1A, CCZ1, HPS1, HPS4, INTU and FUZ). HerMon complexes are known to be Rab effectors and Rab GEFs (Guanine nucleotide Exchange Factors) that regulate vesicular trafficking. Consequently, INTU\/FUZ, their homologous complex, is likely to act as a GEF during activation of Rab GTPases involved in ciliogenesis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Supplementary information<\/jats:title>\n                  <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btz739","type":"journal-article","created":{"date-parts":[[2019,9,26]],"date-time":"2019-09-26T11:28:48Z","timestamp":1569497328000},"page":"990-993","source":"Crossref","is-referenced-by-count":13,"title":["Hexa-Longin domain scaffolds for inter-Rab signalling"],"prefix":"10.1093","volume":"36","author":[{"given":"Luis","family":"Sanchez-Pulido","sequence":"first","affiliation":[{"name":"Medical Research Council Human Genetics Unit, IGMM, University of Edinburgh , Edinburgh EH4 2XU, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris P","family":"Ponting","sequence":"additional","affiliation":[{"name":"Medical Research Council Human Genetics Unit, IGMM, University of Edinburgh , Edinburgh EH4 2XU, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,9,28]]},"reference":[{"key":"2023013110151586300_btz739-B1","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.tcb.2016.12.001","article-title":"From planar cell polarity to ciliogenesis and back: the curious tale of the PPE and CPLANE proteins","volume":"27","author":"Adler","year":"2017","journal-title":"Trends Cell Biol"},{"key":"2023013110151586300_btz739-B2","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1083\/jcb.201604048","article-title":"The small GTPase RSG1 controls a final step in primary cilia initiation","volume":"217","author":"Agbu","year":"2018","journal-title":"J. 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