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Identification of oscillating signals could lead to novel biological insights, yet its investigation is impeded by the extensive computational and statistical knowledge required to perform such analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>To address this issue, we present DiscoRhythm (Discovering Rhythmicity), a user-friendly application for characterizing rhythmicity in temporal biological data. DiscoRhythm is available as a web application or an R\/Bioconductor package for estimating phase, amplitude and statistical significance using four popular approaches to rhythm detection (Cosinor, JTK Cycle, ARSER and Lomb-Scargle). We optimized these algorithms for speed, improving their execution times up to 30-fold to enable rapid analysis of -omic-scale datasets in real-time. Informative visualizations, interactive modules for quality control, dimensionality reduction, periodicity profiling and incorporation of experimental replicates make DiscoRhythm a thorough toolkit for analyzing rhythmicity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Availability and implementation<\/jats:title><jats:p>The DiscoRhythm R package is available on Bioconductor (https:\/\/bioconductor.org\/packages\/DiscoRhythm), with source code available on GitHub (https:\/\/github.com\/matthewcarlucci\/DiscoRhythm) under a GPL-3 license. The web application is securely deployed over HTTPS (https:\/\/disco.camh.ca) and is freely available for use worldwide. Local instances of the DiscoRhythm web application can be created using the R package or by deploying the publicly available Docker container (https:\/\/hub.docker.com\/r\/mcarlucci\/discorhythm).<\/jats:p><\/jats:sec><jats:sec><jats:title>Supplementary information<\/jats:title><jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p><\/jats:sec>","DOI":"10.1093\/bioinformatics\/btz834","type":"journal-article","created":{"date-parts":[[2019,11,6]],"date-time":"2019-11-06T20:11:00Z","timestamp":1573071060000},"page":"1952-1954","source":"Crossref","is-referenced-by-count":50,"title":["DiscoRhythm: an easy-to-use web application and R package for discovering rhythmicity"],"prefix":"10.1093","volume":"36","author":[{"given":"Matthew","family":"Carlucci","sequence":"first","affiliation":[{"name":"The Krembil Family Epigenetics Laboratory, The Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health , Toronto, ON M5T 1R8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Algimantas","family":"Kri\u0161\u010di\u016bnas","sequence":"additional","affiliation":[{"name":"The Krembil Family Epigenetics Laboratory, The Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health , Toronto, ON M5T 1R8, Canada"},{"name":"Institute of Biotechnology, Life Sciences Center, Vilnius University , Vilnius LT-10257, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haohan","family":"Li","sequence":"additional","affiliation":[{"name":"The Krembil Family Epigenetics Laboratory, The Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health , Toronto, ON M5T 1R8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5311-6021","authenticated-orcid":false,"given":"Povilas","family":"Gibas","sequence":"additional","affiliation":[{"name":"The Krembil Family Epigenetics Laboratory, The Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health , Toronto, ON M5T 1R8, Canada"},{"name":"Institute of Biotechnology, Life Sciences Center, Vilnius University , Vilnius LT-10257, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karolis","family":"Koncevi\u010dius","sequence":"additional","affiliation":[{"name":"The Krembil Family Epigenetics Laboratory, The Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health , Toronto, ON M5T 1R8, Canada"},{"name":"Institute of Biotechnology, Life Sciences Center, Vilnius University , Vilnius LT-10257, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Art","family":"Petronis","sequence":"additional","affiliation":[{"name":"The Krembil Family Epigenetics Laboratory, The Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health , Toronto, ON M5T 1R8, Canada"},{"name":"Institute of Biotechnology, Life Sciences Center, Vilnius University , Vilnius LT-10257, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Oh","sequence":"additional","affiliation":[{"name":"The Krembil Family Epigenetics Laboratory, The Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health , Toronto, ON M5T 1R8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,11,8]]},"reference":[{"key":"2023060912002883900_btz834-B1","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1038\/nrg1633","article-title":"Circadian rhythms from multiple oscillators: lessons from diverse organisms","volume":"6","author":"Bell-Pedersen","year":"2005","journal-title":"Nat. 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