{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T00:45:34Z","timestamp":1740185134570,"version":"3.37.3"},"reference-count":5,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2019,11,9]],"date-time":"2019-11-09T00:00:00Z","timestamp":1573257600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01AI121226","R01HL132321","R03HD092776"],"award-info":[{"award-number":["R01AI121226","R01HL132321","R03HD092776"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"School of Public Health at the University of Memphis"},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01AG055406","P30ES017885","R01ES025531","R01ES025574"],"award-info":[{"award-number":["R01AG055406","P30ES017885","R01ES025531","R01ES025574"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Motivation<\/jats:title>\n                  <jats:p>Eosinophils are phagocytic white blood cells with a variety of roles in the immune system. In situations where actual counts are not available, high quality approximations of their cell proportions using indirect markers are critical.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We develop a Bayesian measurement error model to estimate proportions of eosinophils in cord blood, using the cord blood DNA methylation profiles, based on markers of eosinophil cell heterogeneity in blood of adults. The proposed method can be directly extended to other cells across different reference panels. We demonstrate the method\u2019s estimation accuracy using B cells and show that the findings support the proposed approach. The method has been incorporated into the estimateCellCounts function in the minfi package to estimate eosinophil cells proportions in cord blood.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availability and implementation<\/jats:title>\n                  <jats:p>estimateCellCounts function is implemented and available in Bioconductor package minfi.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Supplementary information<\/jats:title>\n                  <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btz839","type":"journal-article","created":{"date-parts":[[2019,11,8]],"date-time":"2019-11-08T20:14:44Z","timestamp":1573244084000},"page":"1923-1924","source":"Crossref","is-referenced-by-count":2,"title":["Estimation of eosinophil cells in cord blood with references based on blood in adults via Bayesian measurement error modeling"],"prefix":"10.1093","volume":"36","author":[{"given":"Yu","family":"Jiang","sequence":"first","affiliation":[{"name":"Division of Epidemiology, Biostatistics and Environmental Health, School of Public Health, University of Memphis , Memphis, TN 38152, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3557-0364","authenticated-orcid":false,"given":"Hongmei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Epidemiology, Biostatistics and Environmental Health, School of Public Health, University of Memphis , Memphis, TN 38152, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shan V","family":"Andrews","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University , Baltimore, MD 21205, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hasan","family":"Arshad","sequence":"additional","affiliation":[{"name":"Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton , Southampton, SO16 6YD, UK"},{"name":"David Hide Asthma and Allergy Research Centre, St Mary's Hospital , Newport, Isle of Wight, PO30 5TG, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Ewart","sequence":"additional","affiliation":[{"name":"Department of Large Animal Clinical Sciences, Michigan State University , East Lansing, MI 48824, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9998-0464","authenticated-orcid":false,"given":"John W","family":"Holloway","sequence":"additional","affiliation":[{"name":"Human Development and Health, Faculty of Medicine, University of Southampton , Southampton, SO16 6YD, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M Daniele","family":"Fallin","sequence":"additional","affiliation":[{"name":"Department of Mental Health, Bloomberg School of Public Health, Johns Hopkins University , Baltimore, MD 21205, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelly M","family":"Bakulski","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health, University of Michigan , Ann Arbor, MI 48109, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wilfried","family":"Karmaus","sequence":"additional","affiliation":[{"name":"Division of Epidemiology, Biostatistics and Environmental Health, School of Public Health, University of Memphis , Memphis, TN 38152, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,11,9]]},"reference":[{"key":"2023060912000876600_btz839-B1","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1093\/bioinformatics\/btu049","article-title":"Minfi: a flexible and comprehensive bioconductor package for the analysis of infinium DNA methylation microarrays","volume":"30","author":"Aryee","year":"2014","journal-title":"Bioinformatics"},{"key":"2023060912000876600_btz839-B2","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/cei.12695","article-title":"Eosinophils: important players in humoral immunity","volume":"183","author":"Berek","year":"2016","journal-title":"Clin. 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