{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T03:48:34Z","timestamp":1776138514630,"version":"3.50.1"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2019,11,18]],"date-time":"2019-11-18T00:00:00Z","timestamp":1574035200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Motivation<\/jats:title><jats:p>We present Link-HD, an approach to integrate multiple datasets. Link-HD is a generalization of \u2018Structuration des Tableaux A Trois Indices de la Statistique\u2013Analyse Conjointe de Tableaux\u2019, a family of methods designed to integrate information from heterogeneous data. Here, we extend the classical approach to deal with broader datasets (e.g. compositional data), methods for variable selection and taxon-set enrichment analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The methodology is demonstrated by integrating rumen microbial communities from cows for which methane yield (CH4y) was individually measured. Our approach reproduces the significant link between rumen microbiota structure and CH4 emission. When analyzing the TARA\u2019s ocean data, Link-HD replicates published results, highlighting the relevance of temperature with members of phyla Proteobacteria on the structure and functionality of this ecosystem.<\/jats:p><\/jats:sec><jats:sec><jats:title>Availability and implementation<\/jats:title><jats:p>The source code, examples and a complete manual are freely available in GitHub https:\/\/github.com\/lauzingaretti\/LinkHD and in Bioconductor https:\/\/bioconductor.org\/packages\/release\/bioc\/html\/LinkHD.html.<\/jats:p><\/jats:sec>","DOI":"10.1093\/bioinformatics\/btz862","type":"journal-article","created":{"date-parts":[[2019,11,15]],"date-time":"2019-11-15T12:11:23Z","timestamp":1573819883000},"page":"2298-2299","source":"Crossref","is-referenced-by-count":9,"title":["Link-HD: a versatile framework to explore and integrate heterogeneous microbial communities"],"prefix":"10.1093","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5618-2630","authenticated-orcid":false,"given":"Laura M","family":"Zingaretti","sequence":"first","affiliation":[{"name":"Plant and Animal Genomics, Statistical and Population Genomics Group, CSIC-IRTA-UAB-UB Consortium, Centre for Research in Agricultural Genomics (CRAG) , 08193 Bellaterra, Spain"},{"name":"IAPCBA and IAPCH, UNVM, Villa Mar\u00eda , C\u00f3rdoba 5900, Argentina"}]},{"given":"Gilles","family":"Renand","sequence":"additional","affiliation":[{"name":"URM Animal Genetics and Integrative Biology, GABI, INRA, AgroParisTech, Universit\u00e9 Paris-Saclay , 78352 Jouy-en-Josas, France"}]},{"given":"Diego P","family":"Morgavi","sequence":"additional","affiliation":[{"name":"Animal Physiology and Livestock Systems Divisions, INRA, Herbivore Research Unit, Clermont Auvergne University , Saint Gen\u00e8s-Champanelle 63122, France"}]},{"given":"Yuliaxis","family":"Ramayo-Caldas","sequence":"additional","affiliation":[{"name":"URM Animal Genetics and Integrative Biology, GABI, INRA, AgroParisTech, Universit\u00e9 Paris-Saclay , 78352 Jouy-en-Josas, France"},{"name":"Animal Breeding and Genetics Program , IRTA, 08140 Caldes de Montbui, Spain"}]}],"member":"286","published-online":{"date-parts":[[2019,11,18]]},"reference":[{"key":"2023062300071265300_btz862-B1","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.foodqual.2006.09.003","article-title":"Analyzing assessors and products in sorting tasks: DISTATIS, theory and applications","volume":"18","author":"Abdi","year":"2007","journal-title":"Food Qual. 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