{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T20:35:00Z","timestamp":1772138100810,"version":"3.50.1"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2019,11,25]],"date-time":"2019-11-25T00:00:00Z","timestamp":1574640000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Science and Engineering Research Council of Canada","doi-asserted-by":"crossref","award":["RGPIN-2018-04296"],"award-info":[{"award-number":["RGPIN-2018-04296"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100022210","name":"Canadian Statistical Sciences Institute","doi-asserted-by":"crossref","award":["CTRMS-342085-2014"],"award-info":[{"award-number":["CTRMS-342085-2014"]}],"id":[{"id":"10.13039\/100022210","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MOP-130311"],"award-info":[{"award-number":["MOP-130311"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Summary<\/jats:title>\n                    <jats:p>We present the R package SimRVSequences to simulate sequence data for pedigrees. SimRVSequences allows for simulations of large numbers of single-nucleotide variants (SNVs) and scales well with increasing numbers of pedigrees. Users provide a sample of pedigrees and SNV data from a sample of unrelated individuals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Availability and implementation<\/jats:title>\n                    <jats:p>SimRVSequences is publicly-available on CRAN https:\/\/cran.r-project.org\/web\/packages\/SimRVSequences\/.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Supplementary information<\/jats:title>\n                    <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btz881","type":"journal-article","created":{"date-parts":[[2019,11,22]],"date-time":"2019-11-22T23:48:03Z","timestamp":1574466483000},"page":"2295-2297","source":"Crossref","is-referenced-by-count":7,"title":["SimRVSequences: an R package to simulate genetic sequence data for pedigrees"],"prefix":"10.1093","volume":"36","author":[{"given":"Christina","family":"Nieuwoudt","sequence":"first","affiliation":[{"name":"Department of Statistics and Actuarial Science, Simon Fraser University , Burnaby, BC V5A 1S6"}]},{"given":"Angela","family":"Brooks-Wilson","sequence":"additional","affiliation":[{"name":"Canada\u2019s Michael Smith Genome Sciences Centre, BC Cancer , Vancouver, BC V5Z 1L3"},{"name":"Department of Biomedical Physiology and Kinesiology, Simon Fraser University , Burnaby, BC V5A 1S6, Canada"}]},{"given":"Jinko","family":"Graham","sequence":"additional","affiliation":[{"name":"Department of Statistics and Actuarial Science, Simon Fraser University , Burnaby, BC V5A 1S6"}]}],"member":"286","published-online":{"date-parts":[[2019,11,25]]},"reference":[{"key":"2023062300071490300_btz881-B1","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1038\/nature09534","article-title":"A map of human genome variation from population-scale sequencing","volume":"467","year":"2010","journal-title":"Nature"},{"key":"2023062300071490300_btz881-B2","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1534\/g3.115.016683","article-title":"XSim: simulation of descendants from ancestors with sequence data","volume":"5","author":"Cheng","year":"2015","journal-title":"G3 (Bethesda)"},{"key":"2023062300071490300_btz881-B3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12859-019-2611-1","article-title":"sim1000G: a user-friendly genetic variant simulator in R for unrelated individuals and family-based designs","volume":"20","author":"Dimitromanolakis","year":"2019","journal-title":"BMC Bioinformatics"},{"key":"2023062300071490300_btz881-B4","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1093\/molbev\/msw211","article-title":"SLiM 2: flexible, interactive forward genetic simulations","volume":"34","author":"Haller","year":"2017","journal-title":"Mol. 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