{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T03:26:57Z","timestamp":1774668417431,"version":"3.50.1"},"reference-count":55,"publisher":"Oxford University Press (OUP)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,8]]},"DOI":"10.1093\/cercor\/bhm207","type":"journal-article","created":{"date-parts":[[2007,12,6]],"date-time":"2007-12-06T01:14:57Z","timestamp":1196903697000},"page":"1856-1864","source":"Crossref","is-referenced-by-count":1037,"title":["Reduced resting-state brain activity in the \u201cdefault network\u201d in normal aging"],"prefix":"10.1093","volume":"18","author":[{"given":"J.S.","family":"Damoiseaux","sequence":"first","affiliation":[]},{"given":"C.F.","family":"Beckmann","sequence":"additional","affiliation":[]},{"given":"E.J. Sanz","family":"Arigita","sequence":"additional","affiliation":[]},{"given":"F.","family":"Barkhof","sequence":"additional","affiliation":[]},{"given":"Ph.","family":"Scheltens","sequence":"additional","affiliation":[]},{"given":"C.J.","family":"Stam","sequence":"additional","affiliation":[]},{"given":"S.M.","family":"Smith","sequence":"additional","affiliation":[]},{"given":"S.A.R.B.","family":"Rombouts","sequence":"additional","affiliation":[]}],"member":"286","published-online":{"date-parts":[[2007,12,5]]},"reference":[{"key":"key\n\t\t\t\t20170520225636_bib1","doi-asserted-by":"crossref","first-page":"e17","DOI":"10.1371\/journal.pcbi.0030017","article-title":"Efficiency and cost of economical brain functional networks","volume":"3","author":"Achard","year":"2007","journal-title":"PLoS Comput Biol"},{"key":"key\n\t\t\t\t20170520225636_bib2","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1098\/rstb.2005.1634","article-title":"Investigations into resting-state connectivity using independent component analysis","volume":"360","author":"Beckmann","year":"2005","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"key\n\t\t\t\t20170520225636_bib3","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1016\/S1053-8119(03)00435-X","article-title":"General multilevel linear modeling for group analysis in FMRI","volume":"20","author":"Beckmann","year":"2003","journal-title":"NeuroImage"},{"key":"key\n\t\t\t\t20170520225636_bib4","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1109\/TMI.2003.822821","article-title":"Probabilistic independent component analysis for functional magnetic resonance imaging","volume":"23","author":"Beckmann","year":"2004","journal-title":"IEEE Trans Med Imaging"},{"key":"key\n\t\t\t\t20170520225636_bib5","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.neuroimage.2004.10.043","article-title":"Tensorial extensions of independent component analysis for multisubject FMRI analysis","volume":"25","author":"Beckmann","year":"2005","journal-title":"NeuroImage"},{"key":"key\n\t\t\t\t20170520225636_bib6","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1162\/089892999563265","article-title":"Conceptual processing during the conscious resting state. A functional MRI study","volume":"11","author":"Binder","year":"1999","journal-title":"J Cogn Neurosci"},{"key":"key\n\t\t\t\t20170520225636_bib7","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1016\/j.neuroimage.2006.02.048","article-title":"Separating respiratory-variation-related fluctuations from neuronal-activity-related fluctuations in fMRI","volume":"31","author":"Birn","year":"2006","journal-title":"NeuroImage"},{"key":"key\n\t\t\t\t20170520225636_bib8","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1002\/mrm.1910340409","article-title":"Functional connectivity in the motor cortex of resting human brain using echo-planar MRI","volume":"34","author":"Biswal","year":"1995","journal-title":"Magn Reson Med"},{"key":"key\n\t\t\t\t20170520225636_bib9","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/j.neuroimage.2007.01.010","article-title":"Unrest at rest: default activity and spontaneous network correlations","volume":"37","author":"Buckner","year":"2007","journal-title":"NeuroImage"},{"key":"key\n\t\t\t\t20170520225636_bib10","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1093\/cercor\/bhg133","article-title":"Task-independent and task-specific age effects on brain activity during working memory, visual attention and episodic retrieval","volume":"14","author":"Cabeza","year":"2004","journal-title":"Cereb Cortex"},{"key":"key\n\t\t\t\t20170520225636_bib11","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1002\/gps.1678","article-title":"Aging and brain activation with working memory tasks: an fMRI study of connectivity","volume":"22","author":"Cook","year":"2007","journal-title":"Int J Geriatr Psychiatry"},{"key":"key\n\t\t\t\t20170520225636_bib12","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1002\/1097-4679(198707)43:4<402::AID-JCLP2270430411>3.0.CO;2-E","article-title":"Relationships between parts A and B of the Trail Making Test","volume":"43","author":"Corrigan","year":"1987","journal-title":"J Clin Psychol"},{"key":"key\n\t\t\t\t20170520225636_bib13","author":"Craik","year":"2000","journal-title":"The Handbook of aging and cognition. Mahwah, (NJ): Lawrence Erlbaum Associates"},{"key":"key\n\t\t\t\t20170520225636_bib14","doi-asserted-by":"crossref","first-page":"13848","DOI":"10.1073\/pnas.0601417103","article-title":"Consistent resting-state networks across healthy subjects","volume":"103","author":"Damoiseaux","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20170520225636_bib15","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1093\/cercor\/bhj112","article-title":"Effects of healthy aging on hippocampal and rhinal memory functions: an event-related fMRI study","volume":"16","author":"Daselaar","year":"2006","journal-title":"Cereb Cortex"},{"key":"key\n\t\t\t\t20170520225636_bib16","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1016\/j.neuroimage.2005.08.035","article-title":"fMRI resting state networks define distinct modes of long-distance interactions in the human brain","volume":"29","author":"De Luca","year":"2006","journal-title":"NeuroImage"},{"key":"key\n\t\t\t\t20170520225636_bib17","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.brainresbull.2006.06.012","article-title":"Independent component model of the default-mode brain function: assessing the impact of active thinking","volume":"70","author":"Esposito","year":"2006","journal-title":"Brain Res Bull"},{"key":"key\n\t\t\t\t20170520225636_bib18","doi-asserted-by":"crossref","first-page":"10046","DOI":"10.1073\/pnas.0604187103","article-title":"Spontaneous neuronal activity distinguishes human dorsal and ventral attention systems","volume":"103","author":"Fox","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20170520225636_bib19","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1038\/nrn2201","article-title":"Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging","volume":"8","author":"Fox","year":"2007","journal-title":"Nat Rev Neurosci"},{"key":"key\n\t\t\t\t20170520225636_bib20","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/j.mri.2006.04.018","article-title":"Large-amplitude, spatially correlated fluctuations in BOLD fMRI signals during extended rest and early sleep stages","volume":"24","author":"Fukunaga","year":"2006","journal-title":"Magn Reson Imaging"},{"key":"key\n\t\t\t\t20170520225636_bib21","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1176\/ajp.2007.164.3.450","article-title":"Aberrant \u201cdefault mode\u201d functional connectivity in schizophrenia","volume":"164","author":"Garrity","year":"2007","journal-title":"Am J Psychiatry"},{"key":"key\n\t\t\t\t20170520225636_bib22","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1037\/0882-7974.4.2.136","article-title":"Task-unrelated-thought frequency as a function of age: a laboratory study","volume":"4","author":"Giambra","year":"1989","journal-title":"Psychol Aging"},{"key":"key\n\t\t\t\t20170520225636_bib23","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1006\/nimg.2001.0786","article-title":"A voxel-based morphometric study of ageing in 465 normal adult human brains","volume":"14","author":"Good","year":"2001","journal-title":"NeuroImage"},{"key":"key\n\t\t\t\t20170520225636_bib24","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1523\/JNEUROSCI.14-03-01450.1994","article-title":"Age-related changes in cortical blood flow activation during visual processing of faces and location","volume":"14","author":"Grady","year":"1994","journal-title":"J Neurosci"},{"key":"key\n\t\t\t\t20170520225636_bib25","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1162\/jocn.2006.18.2.227","article-title":"Age-related changes in brain activity across the adult lifespan","volume":"18","author":"Grady","year":"2006","journal-title":"J Cogn Neurosci"},{"key":"key\n\t\t\t\t20170520225636_bib26","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.biopsych.2006.09.020","article-title":"Resting-state functional connectivity in major depression: abnormally increased contributions from subgenual cingulate cortex and thalamus","volume":"62","author":"Greicius","year":"2007","journal-title":"Biol Psychiatry"},{"key":"key\n\t\t\t\t20170520225636_bib27","doi-asserted-by":"crossref","first-page":"4637","DOI":"10.1073\/pnas.0308627101","article-title":"Default-mode network activity distinguishes Alzheimer's disease from healthy aging: evidence from functional MRI","volume":"101","author":"Greicius","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20170520225636_bib28","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.neuroimage.2006.11.042","article-title":"Regional coherence changes in the early stages of Alzheimer's disease: a combined structural and resting-state functional MRI study","volume":"35","author":"He","year":"2007","journal-title":"NeuroImage"},{"key":"key\n\t\t\t\t20170520225636_bib29","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1006\/nimg.2002.1132","article-title":"Improved optimization for the robust and accurate linear registration and motion correction of brain images","volume":"17","author":"Jenkinson","year":"2002","journal-title":"NeuroImage"},{"key":"key\n\t\t\t\t20170520225636_bib30","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1006\/nimg.1999.0530","article-title":"The relationship between fMRI activation and cerebral atrophy: comparison of normal aging and alzheimer disease","volume":"11","author":"Johnson","year":"2000","journal-title":"NeuroImage"},{"key":"key\n\t\t\t\t20170520225636_bib31","doi-asserted-by":"crossref","first-page":"8275","DOI":"10.1073\/pnas.0600674103","article-title":"Failing to deactivate: resting functional abnormalities in autism","volume":"103","author":"Kennedy","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20170520225636_bib32","doi-asserted-by":"crossref","first-page":"14504","DOI":"10.1073\/pnas.2235925100","article-title":"Functional deactivations: change with age and dementia of the Alzheimer type","volume":"100","author":"Lustig","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20170520225636_bib33","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1006\/nimg.1996.0015","article-title":"Adult age differences in regional cerebral blood flow during visual world identification: evidence from H215O PET","volume":"3","author":"Madden","year":"1996","journal-title":"NeuroImage"},{"key":"key\n\t\t\t\t20170520225636_bib34","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1126\/science.1131295","article-title":"Wandering minds: the default network and stimulus-independent thought","volume":"315","author":"Mason","year":"2007","journal-title":"Science"},{"key":"key\n\t\t\t\t20170520225636_bib35","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.neuroimage.2006.10.007","article-title":"Integrating VBM into the general linear model with voxelwise anatomical covariates","volume":"34","author":"Oakes","year":"2007","journal-title":"NeuroImage"},{"key":"key\n\t\t\t\t20170520225636_bib36","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1212\/WNL.57.4.632","article-title":"Evidence for cortical \u201cdisconnection\u201d as a mechanism of age-related cognitive decline","volume":"57","author":"O'Sullivan","year":"2001","journal-title":"Neurology"},{"key":"key\n\t\t\t\t20170520225636_bib37","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1097\/01.wnr.0000236852.63092.9f","article-title":"Decreased activation of anterior cingulate cortex in the working memory of the elderly","volume":"17","author":"Otsuka","year":"2006","journal-title":"Neuroreport"},{"key":"key\n\t\t\t\t20170520225636_bib38","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1037\/0882-7974.11.4.621","article-title":"Mediators of long-term memory performance across the life span","volume":"11","author":"Park","year":"1996","journal-title":"Psychol Aging"},{"key":"key\n\t\t\t\t20170520225636_bib39","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1006\/nimg.2002.1271","article-title":"Functional imaging of visuospatial processing in Alzheimer's disease","volume":"17","author":"Prvulovic","year":"2002","journal-title":"NeuroImage"},{"key":"key\n\t\t\t\t20170520225636_bib40","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1073\/pnas.98.2.676","article-title":"A default mode of brain function","volume":"98","author":"Raichle","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20170520225636_bib41","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/j.neuroimage.2007.02.041","article-title":"A default mode of brain function: a brief history of an evolving idea","volume":"37","author":"Raichle","year":"2007","journal-title":"NeuroImage"},{"key":"key\n\t\t\t\t20170520225636_bib42","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1093\/cercor\/7.3.268","article-title":"Selective aging of the human cerebral cortex observed in vivo: differential vulnerability of the prefrontal gray matter","volume":"7","author":"Raz","year":"1997","journal-title":"Cereb Cortex"},{"key":"key\n\t\t\t\t20170520225636_bib43","article-title":"Model-free group analysis shows altered BOLD FMRI networks in dementia","author":"Rombouts","year":"2007","journal-title":"Hum Brain Mapp"},{"key":"key\n\t\t\t\t20170520225636_bib44","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.neuroimage.2006.03.061","article-title":"Aging is associated with contrasting changes in local and distant cortical connectivity in the human motor system","volume":"32","author":"Rowe","year":"2006","journal-title":"NeuroImage"},{"key":"key\n\t\t\t\t20170520225636_bib45","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1037\/0882-7974.18.1.91","article-title":"What needs to be explained to account for age-related effects on multiple cognitive variables?","volume":"18","author":"Salthouse","year":"2003","journal-title":"Psychol Aging"},{"key":"key\n\t\t\t\t20170520225636_bib46","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1093\/cercor\/bhj109","article-title":"The neural correlates of declining performance with age: evidence for age-related changes in cognitive control","volume":"16","author":"Sharp","year":"2006","journal-title":"Cereb Cortex"},{"key":"key\n\t\t\t\t20170520225636_bib47","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1093\/cercor\/7.3.193","article-title":"Top-down modulation of early sensory cortex","volume":"7","author":"Shulman","year":"1997","journal-title":"Cereb Cortex"},{"key":"key\n\t\t\t\t20170520225636_bib48","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1002\/hbm.10062","article-title":"Fast robust automated brain extraction","volume":"17","author":"Smith","year":"2002","journal-title":"Hum Brain Mapp"},{"key":"key\n\t\t\t\t20170520225636_bib49","doi-asserted-by":"crossref","first-page":"S208","DOI":"10.1016\/j.neuroimage.2004.07.051","article-title":"Advances in functional and structural MR image analysis and implementation as FSL","volume":"23","author":"Smith","year":"2004","journal-title":"NeuroImage"},{"key":"key\n\t\t\t\t20170520225636_bib50","doi-asserted-by":"crossref","first-page":"551","DOI":"10.3758\/BF03197257","article-title":"Stimulus-independent thought depends on central executive resources","volume":"23","author":"Teasdale","year":"1995","journal-title":"Mem Cognit"},{"key":"key\n\t\t\t\t20170520225636_bib51","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/nature05758","article-title":"Intrinsic functional architecture in the anaesthetized monkey brain","volume":"447","author":"Vincent","year":"2007","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170520225636_bib52","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1016\/j.neurobiolaging.2005.08.011","article-title":"Age and cholinergic effects on hemodynamics and functional coherence of human hippocampus","volume":"27","author":"Wink","year":"2006","journal-title":"Neurobiol Aging"},{"key":"key\n\t\t\t\t20170520225636_bib53","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.neulet.2007.06.011","article-title":"Aging influence on functional connectivity of the motor network in the resting state","volume":"422","author":"Wu","year":"2007","journal-title":"Neurosci Lett"},{"key":"key\n\t\t\t\t20170520225636_bib54","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1109\/42.906424","article-title":"Segmentation of brain MR images through a hidden Markov random field model and the expectation-maximization algorithm","volume":"20","author":"Zhang","year":"2001","journal-title":"IEEE Trans Med Imaging"},{"key":"key\n\t\t\t\t20170520225636_bib55","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.neulet.2007.02.081","article-title":"Functional dysconnectivity of the dorsolateral prefrontal cortex in first-episode schizophrenia using resting-state fMRI","volume":"417","author":"Zhou","year":"2007","journal-title":"Neurosci Lett"}],"container-title":["Cerebral Cortex"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/cercor\/article-pdf\/18\/8\/1856\/17300529\/bhm207.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,5]],"date-time":"2019-05-05T15:50:23Z","timestamp":1557071423000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cercor\/article-lookup\/doi\/10.1093\/cercor\/bhm207"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12,5]]},"references-count":55,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2007,12,5]]},"published-print":{"date-parts":[[2008,8]]}},"URL":"https:\/\/doi.org\/10.1093\/cercor\/bhm207","relation":{},"ISSN":["1460-2199","1047-3211"],"issn-type":[{"value":"1460-2199","type":"electronic"},{"value":"1047-3211","type":"print"}],"subject":[],"published":{"date-parts":[[2007,12,5]]}}}