{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T16:45:25Z","timestamp":1784220325516,"version":"3.55.0"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T00:00:00Z","timestamp":1682035200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["41571402"],"award-info":[{"award-number":["41571402"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,4,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Neural network elements such as motif, backbone and influential nodes play important roles in neural network computation. Increasing researches have been applying complex network methods in order to identify different essential structures within complex neural networks. However, the distinct properties of synapses that build the neural network are often neglected, such as the difference between chemical synapses and electrical synapses. By separating these distinct synapses, we can identify a novel repertoire of neural motifs and greatly expand neural motif families in neural systems. Based on the expanded motif families, we further propose a novel neural-motif-based algorithm to extract the backbone in the neural network. The backbone circuit we extracted from Caenorhabditis elegans connectome controls an essential motor behaviour in C. elegans. Furthermore, we develop a novel neural-motif-based algorithm to identify influential neurons. Compared with the influential neurons identified using existing methods, the neurons identified in this work provide more information in related to their functions. These methods have been successfully applied to identify a series of network features in C. elegans, providing a biologically interpretable way of exploring the structure of neural network.<\/jats:p>","DOI":"10.1093\/comnet\/cnad013","type":"journal-article","created":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T07:25:37Z","timestamp":1684826737000},"source":"Crossref","is-referenced-by-count":3,"title":["Neuronal motifs reveal backbone structure and influential neurons of neural network in <i>C. elegans<\/i>"],"prefix":"10.1093","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5968-4318","authenticated-orcid":false,"given":"Jian","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Automation, Shanghai Jiao Tong University , Shanghai 200240"},{"name":"China and Key Laboratory of System Control and Information Processing, Ministry of Education , Shanghai 200240, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Yuan","sequence":"additional","affiliation":[{"name":"Institute of Machine Intelligence, University of Shanghai for Science and Technology , Shanghai 200093, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Automation, Shanghai Jiao Tong University , Shanghai 200240"},{"name":"China and Key Laboratory of System Control and Information Processing, Ministry of Education , Shanghai 200240, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Automation, Shanghai Jiao Tong University , Shanghai 200240"},{"name":"China and Key Laboratory of System Control and Information Processing, Ministry of Education , Shanghai 200240, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Huo","sequence":"additional","affiliation":[{"name":"Department of Automation, Shanghai Jiao Tong University , Shanghai 200240"},{"name":"China and Key Laboratory of System Control and Information Processing, Ministry of Education , Shanghai 200240, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoyu","family":"Li","sequence":"additional","affiliation":[{"name":"Queensland Brain Institute, The University of Queensland , Brisbane QLD 4072, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Automation, Shanghai Jiao Tong University , Shanghai 200240"},{"name":"China and Key Laboratory of System Control and Information Processing, Ministry of Education , Shanghai 200240, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,5,22]]},"reference":[{"key":"2023052307251202900_cnad013-B1","doi-asserted-by":"crossref","first-page":"e106132","DOI":"10.1371\/journal.pone.0106132","article-title":"Identification of important nodes in directed biological networks: A network motif approach","volume":"9","author":"Wang","year":"2014","journal-title":"PLoS ONE"},{"key":"2023052307251202900_cnad013-B2","first-page":"xii","article-title":"Statistical mechanics of complex networks","volume":"74","author":"Albert","year":"2001","journal-title":"Rev. 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