{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T00:32:55Z","timestamp":1767918775276,"version":"3.49.0"},"reference-count":31,"publisher":"Oxford University Press (OUP)","funder":[{"name":"Jiangsu Provincial Key Medical Discipline"},{"name":"Invigorating Health Care through Science"},{"name":"Technology and Education","award":["ZDXKA2016014"],"award-info":[{"award-number":["ZDXKA2016014"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Circulating tumor cells\/microemboli (CTCs\/CTMs) are malignant cells that depart from cancerous lesions and shed into the bloodstream. Analysis of CTCs can allow the investigation of tumor cell biomarker expression from a non-invasive liquid biopsy. To date, high-throughput technologies have become a powerful tool to provide a genome-wide view of transcriptomic changes associated with CTCs\/CTMs. These data provided us much information to understand the tumor heterogeneity, and the underlying molecular mechanism of tumor metastases. Unfortunately, these data have been deposited into various repositories, and a uniform resource for the cancer metastasis is still unavailable. To this end, we integrated previously published transcriptome datasets of CTCs\/CTMs and constructed a web-accessible database. The first release of ctcRbase contains 526 CTCs\/CTM samples across seven cancer types. The expression of 14\u2009631 mRNAs and 3642 long non-coding RNAs of CTCs\/CTMs were included. Experimental validations from the published literature are also included. Since CTCs\/CTMs are considered to be precursors of metastases, ctcRbase also collected the expression data of primary tumors and metastases, which allows user to discover a unique \u2018circulating tumor cell gene signature\u2019 that is distinct from primary tumor and metastases. An easy-to-use database was constructed to query and browse CTCs\/CTMs genes. ctcRbase can be freely accessible at http:\/\/www.origin-gene.cn\/database\/ctcRbase\/.<\/jats:p>","DOI":"10.1093\/database\/baaa020","type":"journal-article","created":{"date-parts":[[2020,3,3]],"date-time":"2020-03-03T12:19:17Z","timestamp":1583237957000},"source":"Crossref","is-referenced-by-count":31,"title":["ctcRbase: the gene expression database of circulating tumor cells and microemboli"],"prefix":"10.1093","volume":"2020","author":[{"given":"Lei","family":"Zhao","sequence":"first","affiliation":[{"name":"Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, School of Life Sciences, East China Normal University, No.500 Dongchuan Road, Shanghai, 200241 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohong","family":"Wu","sequence":"first","affiliation":[{"name":"Department of General Surgery, the Affiliated Yixing Hospital of Jiangsu University, No. 75 Zhenguan Road, Yixing, Jiangsu 214200, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tong","family":"Li","sequence":"first","affiliation":[{"name":"Thyroid and breast surgery, the Fourth Hospital of Jinan City, No. 50 Shifan Road, Jinan, Shandong 250021, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Luo","sequence":"first","affiliation":[{"name":"Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, School of Life Sciences, East China Normal University, No.500 Dongchuan Road, Shanghai, 200241 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong","family":"Dong","sequence":"first","affiliation":[{"name":"Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, School of Life Sciences, East China Normal University, No.500 Dongchuan Road, Shanghai, 200241 China"},{"name":"Cancer Institute, Xuzhou Medical University, No. 84 West huaihai Road, Xuzhou, Jiangsu 221006, China"},{"name":"Center of Clinical Oncology, Affiliated Hospital of Xuzhou Medical University, No.315 West huaihai Road, Xuzhou, Jiangsu 221006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,4,15]]},"reference":[{"key":"2020041511155608200_ref1","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1373\/clinchem.2012.194258","article-title":"Circulating tumor cells: liquid biopsy of cancer","volume":"59","author":"Alix-Panabieres","year":"2013","journal-title":"Clin Chem"},{"key":"2020041511155608200_ref2","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1056\/NEJMoa040766","article-title":"Circulating tumor cells, disease progression, and survival in metastatic breast cancer","volume":"351","author":"Cristofanilli","year":"2004","journal-title":"N Engl J 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