{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T17:32:10Z","timestamp":1779384730977,"version":"3.53.1"},"reference-count":16,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2020,3,27]],"date-time":"2020-03-27T00:00:00Z","timestamp":1585267200000},"content-version":"vor","delay-in-days":86,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Guangzhou Municipal Psychiatric Disease Clinical Transformation Laboratory","award":["201805010009"],"award-info":[{"award-number":["201805010009"]}]},{"name":"Guangzhou Municipal Key Discipline in Medicine","award":["2017\u20132019"],"award-info":[{"award-number":["2017\u20132019"]}]},{"name":"Key Laboratory for Innovation Platform Plan, Science and Technology Program of Guangzhou, China"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title\/>\n                  <jats:p>Ferroptosis is a mode of regulated cell death that depends on iron. Cells die from the toxic accumulation of lipid reactive oxygen species. Ferroptosis is tightly linked to a variety of human diseases, such as cancers and degenerative diseases. The ferroptotic process is complicated and consists of a wide range of metabolites and biomolecules. Although great progress has been achieved, the mechanism of ferroptosis remains enigmatic. We have currently entered an era of extensive knowledge advancement, and thus, it is important to find ways to organize and utilize data efficiently. We have observed a high-quality knowledge base of ferroptosis research is lacking. In this study, we downloaded 784 ferroptosis articles from the PubMed database. Ferroptosis regulators and markers and associated diseases were extracted from these articles and annotated. In summary, 253 regulators (including 108 drivers, 69 suppressors, 35 inducers and 41 inhibitors), 111 markers and 95 ferroptosis-disease associations were found. We then developed FerrDb, the first manually curated database for regulators and markers of ferroptosis and ferroptosis-disease associations. The database has a user-friendly interface, and it will be updated every 6\u00a0months to offer long-term service. FerrDb is expected to help researchers acquire insights into ferroptosis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title\/>\n                  <jats:p>Database URL: http:\/\/www.zhounan.org\/ferrdb<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/database\/baaa021","type":"journal-article","created":{"date-parts":[[2020,2,26]],"date-time":"2020-02-26T12:14:41Z","timestamp":1582719281000},"source":"Crossref","is-referenced-by-count":615,"title":["FerrDb: a manually curated resource for regulators and markers of ferroptosis and ferroptosis-disease associations"],"prefix":"10.1093","volume":"2020","author":[{"given":"Nan","family":"Zhou","sequence":"first","affiliation":[{"name":"Affiliated Brain Hospital of Guangzhou Medical University, 36 Mingxin Rd, Guangzhou, 510370, China"},{"name":"Guangzhou Huiai Hospital, 36 Mingxin Rd, Guangzhou, 510370, China"},{"name":"Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders, 36 Mingxin Rd, Guangzhou, 510370, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinku","family":"Bao","sequence":"first","affiliation":[{"name":"Key Laboratory of the State Ministry of Education for Bio-Resources and Ecologic Environment, College of Life Sciences, Sichuan University, 29 Wangjiang Rd, Chengdu, 610064, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,3,27]]},"reference":[{"key":"2020032711045761400_ref1","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.tcb.2015.10.014","article-title":"Ferroptosis: death by lipid peroxidation","volume":"26","author":"Yang","year":"2016","journal-title":"Trends Cell Biol."},{"key":"2020032711045761400_ref2","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/cdd.2014.137","article-title":"Essential versus accessory aspects of cell death: recommendations of the NCCD 2015","volume":"22","author":"Galluzzi","year":"2014","journal-title":"Cell Death Differ."},{"key":"2020032711045761400_ref3","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.freeradbiomed.2018.09.043","article-title":"The development of the concept of ferroptosis","volume":"133","author":"Hirschhorn","year":"2019","journal-title":"Free Radic. Biol. 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J. Cancer"},{"key":"2020032711045761400_ref8","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1084\/jem.20140857","article-title":"T cell lipid peroxidation induces ferroptosis and prevents immunity to infection","volume":"212","author":"Matsushita","year":"2015","journal-title":"J. Exp. Med."},{"key":"2020032711045761400_ref9","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s12950-019-0216-0","article-title":"Ferroptosis inhibitor alleviates radiation-induced lung fibrosis (RILF) via down-regulation of TGF-\u03b21","volume":"16","author":"Li","year":"2019","journal-title":"J. Inflamm."},{"key":"2020032711045761400_ref10","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1016\/j.biopha.2018.11.030","article-title":"Artesunate alleviates liver fibrosis by regulating ferroptosis signaling pathway","volume":"109","author":"Kong","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"2020032711045761400_ref11","doi-asserted-by":"crossref","first-page":"btv557","DOI":"10.1093\/bioinformatics\/btv557","article-title":"Cytoscape. js: a graph theory library for visualisation and analysis","author":"Franz","year":"2015","journal-title":"Bioinformatics"},{"key":"2020032711045761400_ref12","doi-asserted-by":"crossref","first-page":"2801","DOI":"10.1242\/jcs.038166","article-title":"Mechanisms by which Bak and Bax permeabilise mitochondria during apoptosis","volume":"122","author":"Dewson","year":"2009","journal-title":"J. Cell Sci"},{"key":"2020032711045761400_ref13","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1038\/nrc1186","article-title":"The role of notch in tumorigenesis: oncogene or tumour suppressor?","volume":"3","author":"Radtke","year":"2003","journal-title":"Nat. Rev. Cancer"},{"key":"2020032711045761400_ref14","doi-asserted-by":"crossref","first-page":"2881","DOI":"10.1080\/15384101.2015.1068479","article-title":"Dynamic roles of p53-mediated metabolic activities in ROS-induced stress responses","volume":"14","author":"Jiang","year":"2015","journal-title":"Cell Cycle"},{"key":"2020032711045761400_ref15","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1016\/j.celrep.2017.07.055","article-title":"The tumor suppressor p53 limits ferroptosis by blocking DPP4 activity","volume":"20","author":"Xie","year":"2017","journal-title":"Cell Rep."},{"key":"2020032711045761400_ref16","doi-asserted-by":"crossref","first-page":"e1002165","DOI":"10.1371\/journal.pbio.1002165","article-title":"The economics of reproducibility in preclinical research","volume":"13","author":"Freedman","year":"2015","journal-title":"PLOS Biol."}],"container-title":["Database"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/database\/article-pdf\/doi\/10.1093\/database\/baaa021\/32972598\/baaa021.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/database\/article-pdf\/doi\/10.1093\/database\/baaa021\/32972598\/baaa021.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,3,27]],"date-time":"2020-03-27T15:47:00Z","timestamp":1585324020000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/database\/article\/doi\/10.1093\/database\/baaa021\/5812716"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,1]]},"references-count":16,"URL":"https:\/\/doi.org\/10.1093\/database\/baaa021","relation":{},"ISSN":["1758-0463"],"issn-type":[{"value":"1758-0463","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020]]},"published":{"date-parts":[[2020,1,1]]},"article-number":"baaa021"}}