{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T11:49:16Z","timestamp":1753876156132,"version":"3.41.2"},"reference-count":35,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2020,5,5]],"date-time":"2020-05-05T00:00:00Z","timestamp":1588636800000},"content-version":"vor","delay-in-days":125,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31501871","31530068"],"award-info":[{"award-number":["31501871","31530068"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Key Research Fund on Sciences and Technologies for Joint Academic Institute and Local Enterprises of Sichuan","award":["2018Jz0008"],"award-info":[{"award-number":["2018Jz0008"]}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2012017yjsy153"],"award-info":[{"award-number":["2012017yjsy153"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Macaques are the most widely used non-human primates in biomedical research. The genetic divergence between these animal models is responsible for their phenotypic differences in response to certain diseases. However, the macaque single nucleotide polymorphism resources mainly focused on rhesus macaque (Macaca mulatta), which hinders the broad research and biomedical application of other macaques. In order to overcome these limitations, we constructed a database named MACSNVdb that focuses on the interspecies genetic diversity among macaque genomes. MACSNVdb is a web-enabled database comprising ~74.51 million high-quality non-redundant single nucleotide variants (SNVs) identified among 20 macaque individuals from six species groups (muttla, fascicularis, sinica, arctoides, silenus, sylvanus). In addition to individual SNVs, MACSNVdb also allows users to browse and retrieve groups of user-defined SNVs. In particular, users can retrieve non-synonymous SNVs that may have deleterious effects on protein structure or function within macaque orthologs of human disease and drug-target genes. Besides position, alleles and flanking sequences, MACSNVdb integrated additional genomic information including SNV annotations and gene functional annotations. MACSNVdb will facilitate biomedical researchers to discover molecular mechanisms of diverse responses to diseases as well as primatologist to perform population genetic studies. We will continue updating MACSNVdb with newly available sequencing data and annotation to keep the resource up to date.<\/jats:p>\n               <jats:p>Database URL: http:\/\/big.cdu.edu.cn\/macsnvdb\/<\/jats:p>","DOI":"10.1093\/database\/baaa027","type":"journal-article","created":{"date-parts":[[2020,3,23]],"date-time":"2020-03-23T20:08:55Z","timestamp":1584994135000},"source":"Crossref","is-referenced-by-count":0,"title":["MACSNVdb: a high-quality SNV database for interspecies genetic divergence investigation among macaques"],"prefix":"10.1093","volume":"2020","author":[{"given":"Lianming","family":"Du","sequence":"first","affiliation":[{"name":"Institute for Advanced Study, Chengdu University, 2025 Chengluo Rd, Chengdu 610106, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, 20 Section 3, South Renmin Rd, Chengdu 610041, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qin","family":"Liu","sequence":"first","affiliation":[{"name":"Key Laboratory of Bio-Resources and Eco-Environment, Ministry of Education, College of Life Science, Sichuan University, 29 Wangjiang Rd, Chengdu 610065, China"},{"name":"College of Life Sciences and Food Engineering, Yibin University, 8 Wuliangye Rd, Yibin 644000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Li","sequence":"first","affiliation":[{"name":"Key Laboratory of Bio-Resources and Eco-Environment, Ministry of Education, College of Life Science, Sichuan University, 29 Wangjiang Rd, Chengdu 610065, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiuyue","family":"Zhang","sequence":"first","affiliation":[{"name":"Key Laboratory of Bio-Resources and Eco-Environment, Ministry of Education, College of Life Science, Sichuan University, 29 Wangjiang Rd, Chengdu 610065, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinchuan","family":"Xing","sequence":"first","affiliation":[{"name":"Department of Genetics, Rutgers, the State University of New Jersey, 145 Bevier Rd, Piscataway, NJ 08854, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bisong","family":"Yue","sequence":"first","affiliation":[{"name":"Key Laboratory of Bio-Resources and Eco-Environment, Ministry of Education, College of Life Science, Sichuan University, 29 Wangjiang Rd, Chengdu 610065, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Li","sequence":"first","affiliation":[{"name":"Key Laboratory of Bio-Resources and Eco-Environment, Ministry of Education, College of Life Science, Sichuan University, 29 Wangjiang Rd, Chengdu 610065, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenxin","family":"Fan","sequence":"first","affiliation":[{"name":"Key Laboratory of Bio-Resources and Eco-Environment, Ministry of Education, College of Life Science, Sichuan University, 29 Wangjiang Rd, Chengdu 610065, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,5,4]]},"reference":[{"key":"2020050421174469000_ref1","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1002\/ajp.20054","article-title":"Use of primates in research: a global overview","volume":"63","author":"Carlsson","year":"2004","journal-title":"Am. 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