{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T04:22:50Z","timestamp":1781756570220,"version":"3.54.5"},"reference-count":44,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2020,6,4]],"date-time":"2020-06-04T00:00:00Z","timestamp":1591228800000},"content-version":"vor","delay-in-days":155,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Johannes Gutenberg University"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cells operate and react to environmental signals thanks to a complex network of protein\u2013protein interactions (PPIs), the malfunction of which can severely disrupt cellular homeostasis. As a result, mapping and analyzing protein networks are key to advancing our understanding of biological processes and diseases. An invaluable part of these endeavors has been the house mouse (Mus musculus), the mammalian model organism par excellence, which has provided insights into human biology and disorders. The importance of investigating PPI networks in the context of mouse prompted us to develop the Mouse Integrated Protein\u2013Protein Interaction rEference (MIPPIE). MIPPIE inherits a robust infrastructure from HIPPIE, its sister database of human PPIs, allowing for the assembly of reliable networks supported by different evidence sources and high-quality experimental techniques. MIPPIE networks can be further refined with tissue, directionality and effect information through a user-friendly web interface. Moreover, all MIPPIE data and meta-data can be accessed via a REST web service or downloaded as text files, thus facilitating the integration of mouse PPIs into follow-up bioinformatics pipelines.<\/jats:p>","DOI":"10.1093\/database\/baaa035","type":"journal-article","created":{"date-parts":[[2020,4,30]],"date-time":"2020-04-30T19:09:49Z","timestamp":1588273789000},"source":"Crossref","is-referenced-by-count":18,"title":["MIPPIE: the mouse integrated protein\u2013protein interaction reference"],"prefix":"10.1093","volume":"2020","author":[{"given":"Gregorio","family":"Alanis-Lobato","sequence":"first","affiliation":[{"name":"Faculty of Biology, Johannes Gutenberg University, Biozentrum I, Hans-Dieter-H\u00fcsch-Weg 15, 55128 Mainz, Germany"},{"name":"Human Embryo and Stem Cell Laboratory, The Francis Crick Institute, 1 Midland Road, NW1 1AT London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jannik S","family":"M\u00f6llmann","sequence":"first","affiliation":[{"name":"Faculty of Biology, Johannes Gutenberg University, Biozentrum I, Hans-Dieter-H\u00fcsch-Weg 15, 55128 Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin H","family":"Schaefer","sequence":"first","affiliation":[{"name":"Department of Experimental Oncology, European Institute of Oncology IRCCS, Via Adamello 16, 20139 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel A","family":"Andrade-Navarro","sequence":"first","affiliation":[{"name":"Faculty of Biology, Johannes Gutenberg University, Biozentrum I, Hans-Dieter-H\u00fcsch-Weg 15, 55128 Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,6,4]]},"reference":[{"key":"2020060406200353400_ref1","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/S0968-0004(01)01938-7","article-title":"Macromolecular crowding: obvious but underappreciated","volume":"26","author":"Ellis","year":"2001","journal-title":"Trends Biochem. 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