{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T02:56:09Z","timestamp":1778640969814,"version":"3.51.4"},"reference-count":56,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"vor","delay-in-days":182,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Natural Science Foundation of the Jiangsu Higher Education Institutions of China","award":["18KJD520003"],"award-info":[{"award-number":["18KJD520003"]}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2016YFC1306605"],"award-info":[{"award-number":["2016YFC1306605"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61602332"],"award-info":[{"award-number":["61602332"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31670851"],"award-info":[{"award-number":["31670851"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Congenital heart disease (CHD) is one of the most common birth defects, with complex genetic and environmental etiologies. The reports of genetic variation associated with CHD have increased dramatically in recent years due to the revolutionary development of molecular technology. However, CHD is a heterogeneous disease, and its genetic origins remain inconclusive in most patients. Here we present a database of genetic variations for non-syndromic CHD (NS-CHD). By manually literature extraction and analyses, 5345 NS-CHD-associated genetic variations were collected, curated and stored in the public online database. The objective of our database is to provide the most comprehensive updates on NS-CHD genetic research and to aid systematic analyses of pathogenesis of NS-CHD in molecular level and the correlation between NS-CHD genotypes and phenotypes.<\/jats:p>\n               <jats:p>Database URL: http:\/\/www.sysbio.org.cn\/CHDGKB\/<\/jats:p>","DOI":"10.1093\/database\/baaa048","type":"journal-article","created":{"date-parts":[[2020,5,31]],"date-time":"2020-05-31T11:06:49Z","timestamp":1590923209000},"source":"Crossref","is-referenced-by-count":10,"title":["CHDGKB: a knowledgebase for systematic understanding of genetic variations associated with non-syndromic congenital heart disease"],"prefix":"10.1093","volume":"2020","author":[{"given":"Lan","family":"Yang","sequence":"first","affiliation":[{"name":"Center for Systems Biology, Soochow University, Suzhou 215006, China"},{"name":"Center of Prenatal Diagnosis, Wuxi Maternal and Child Health Hospital Affiliated to Nanjing Medical University, Wuxi 214002, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Yang","sequence":"first","affiliation":[{"name":"School of Computer Science and Technology, Soochow University, Suzhou 215006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xingyun","family":"Liu","sequence":"first","affiliation":[{"name":"Center for Systems Biology, Soochow University, Suzhou 215006, China"},{"name":"Institutes for Systems Genetics, West China Hospital, Sichuan University, Chengdu 610041, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongquan","family":"Chen","sequence":"first","affiliation":[{"name":"School of Computer Science and Technology, Soochow University, Suzhou 215006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yalan","family":"Chen","sequence":"first","affiliation":[{"name":"Center for Systems Biology, Soochow University, Suzhou 215006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuxin","family":"Lin","sequence":"first","affiliation":[{"name":"Center for Systems Biology, Soochow University, Suzhou 215006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Sun","sequence":"first","affiliation":[{"name":"Institutes for Systems Genetics, West China Hospital, Sichuan University, Chengdu 610041, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bairong","family":"Shen","sequence":"first","affiliation":[{"name":"Institutes for Systems Genetics, West China Hospital, Sichuan University, Chengdu 610041, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,7,1]]},"reference":[{"key":"2020070103235421800_ref1","first-page":"e38","article-title":"Heart disease and stroke statistics-2016 update: a report from the American Heart Association","volume":"133","author":"Writing Group Members","year":"2016","journal-title":"Circulation"},{"key":"2020070103235421800_ref2","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/nrcardio.2010.166","article-title":"The changing epidemiology of congenital heart disease","volume":"8","author":"van der Bom","year":"2011","journal-title":"Nat. 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