{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T19:37:55Z","timestamp":1784921875436,"version":"3.55.0"},"reference-count":25,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2020,8,26]],"date-time":"2020-08-26T00:00:00Z","timestamp":1598400000000},"content-version":"vor","delay-in-days":238,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Mega-project for Innovative Drugs","award":["2019ZX09721001"],"award-info":[{"award-number":["2019ZX09721001"]}]},{"name":"Jiangsu Province Key Research and Development Program","award":["BE2017314"],"award-info":[{"award-number":["BE2017314"]}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2016YFD0501308"],"award-info":[{"award-number":["2016YFD0501308"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Antimicrobial peptides (AMPs) have been regarded as a potential weapon to fight against drug-resistant bacteria, which is threating the globe. Thus, more and more AMPs had been designed or identified. There is a need to integrate them into a platform for researchers to facilitate investigation and analyze existing AMPs. The AMP database has become an important tool for the discovery and transformation of AMPs as agents. A database linking antimicrobial peptides (LAMPs), launched in 2013, serves as a comprehensive tool to supply exhaustive information of AMP on a single platform. LAMP2, an updated version of LAMP, holds 23\u2009253 unique AMP sequences and expands to link 16 public AMP databases. In the current version, there are more than 50% (12\u2009236) sequences only linking a single database and more than 45% of AMPs linking two or more database links. Additionally, updated categories based on primary structure, collection, composition, source and function have been integrated into LAMP2. Peptides in LAMP2 have been integrated in 8 major functional classes and 38 functional activities. More than 89% (20\u2009909) of the peptides are experimentally validated peptides. A total of 1924 references were extracted and regarded as the evidence for supporting AMP activity and cytotoxicity. The updated version will be helpful to the scientific community.<\/jats:p>","DOI":"10.1093\/database\/baaa061","type":"journal-article","created":{"date-parts":[[2020,8,5]],"date-time":"2020-08-05T11:15:49Z","timestamp":1596626149000},"source":"Crossref","is-referenced-by-count":116,"title":["LAMP2: a major update of the database linking antimicrobial peptides"],"prefix":"10.1093","volume":"2020","author":[{"given":"Guizi","family":"Ye","sequence":"first","affiliation":[{"name":"State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai 200438, China"},{"name":"Kunshan Bio-Green Biotechnology Co., Ltd, Kunshan 215316, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyu","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai 200438, China"},{"name":"Shanghai High-Tech United Bio-Technological R&D Co., Ltd, Shanghai 201206, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinjiang","family":"Huang","sequence":"additional","affiliation":[{"name":"Kunshan Bio-Green Biotechnology Co., Ltd, Kunshan 215316, Jiangsu, China"},{"name":"Shanghai High-Tech United Bio-Technological R&D Co., Ltd, Shanghai 201206, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Shanghai High-Tech United Bio-Technological R&D Co., Ltd, Shanghai 201206, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuikui","family":"Ge","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai 200438, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guodong","family":"Li","sequence":"additional","affiliation":[{"name":"Shanghai High-Tech United Bio-Technological R&D Co., Ltd, Shanghai 201206, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang","family":"Zhong","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai 200438, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingshan","family":"Huang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai 200438, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,8,25]]},"reference":[{"key":"2020082519170323900_ref1","doi-asserted-by":"crossref","first-page":"281","DOI":"10.3389\/fphar.2018.00281","article-title":"Antimicrobial peptides and their therapeutic potential for bacterial skin infections and wounds","volume":"9","author":"Pfalzgraff","year":"2018","journal-title":"Front. Pharmacol."},{"key":"2020082519170323900_ref2","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.cmi.2019.09.015","article-title":"Current landscape in the discovery of novel antibacterial agents","volume":"26","author":"Vila","year":"2019","journal-title":"Clin. Microbiol. Infect."},{"key":"2020082519170323900_ref3","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.biotechadv.2017.02.001","article-title":"Computational tools for exploring sequence databases as a resource for antimicrobial peptides","volume":"35","author":"Porto","year":"2017","journal-title":"Biotechnol. Adv."},{"key":"2020082519170323900_ref4","doi-asserted-by":"crossref","first-page":"D1087","DOI":"10.1093\/nar\/gkv1278","article-title":"APD3: the antimicrobial peptide database as a tool for research and education","volume":"44","author":"Wang","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"2020082519170323900_ref5","doi-asserted-by":"crossref","first-page":"D1104","DOI":"10.1093\/nar\/gkv1174","article-title":"DBAASP v.2: an enhanced database of structure and antimicrobial\/cytotoxic activity of natural and synthetic peptides","volume":"44","author":"Pirtskhalava","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"2020082519170323900_ref6","doi-asserted-by":"crossref","first-page":"D1094","DOI":"10.1093\/nar\/gkv1051","article-title":"CAMP(R3): a database on sequences, structures and signatures of antimicrobial peptides","volume":"44","author":"Waghu","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"2020082519170323900_ref7","doi-asserted-by":"crossref","first-page":"D285","DOI":"10.1093\/nar\/gky1030","article-title":"dbAMP: an integrated resource for exploring antimicrobial peptides with functional activities and physicochemical properties on transcriptome and proteome data","volume":"47","author":"Jhong","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"2020082519170323900_ref8","doi-asserted-by":"crossref","first-page":"D837","DOI":"10.1093\/nar\/gku892","article-title":"CancerPPD: a database of anticancer peptides and proteins","volume":"43","author":"Tyagi","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"2020082519170323900_ref9","doi-asserted-by":"crossref","first-page":"D444","DOI":"10.1093\/nar\/gkt1008","article-title":"Hemolytik: a database of experimentally determined hemolytic and non-hemolytic peptides","volume":"42","author":"Gautam","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"2020082519170323900_ref10","doi-asserted-by":"crossref","first-page":"e0181748","DOI":"10.1371\/journal.pone.0181748","article-title":"THPdb: database of FDA-approved peptide and protein therapeutics","volume":"12","author":"Usmani","year":"2017","journal-title":"PLoS One"},{"key":"2020082519170323900_ref11","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jgar.2016.10.003","article-title":"InverPep: a database of invertebrate antimicrobial peptides","volume":"8","author":"Gomez","year":"2017","journal-title":"J. Glob. Antimicrob. Resist."},{"key":"2020082519170323900_ref12","doi-asserted-by":"crossref","first-page":"D774","DOI":"10.1093\/nar\/gkp1021","article-title":"CAMP: a useful resource for research on antimicrobial peptides","volume":"38","author":"Thomas","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"2020082519170323900_ref13","doi-asserted-by":"crossref","first-page":"D1154","DOI":"10.1093\/nar\/gkt1157","article-title":"CAMP: collection of sequences and structures of antimicrobial peptides","volume":"42","author":"Waghu","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"2020082519170323900_ref14","doi-asserted-by":"crossref","first-page":"D1119","DOI":"10.1093\/nar\/gkv1114","article-title":"SATPdb: a database of structurally annotated therapeutic peptides","volume":"44","author":"Singh","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"2020082519170323900_ref15","doi-asserted-by":"crossref","first-page":"e66557","DOI":"10.1371\/journal.pone.0066557","article-title":"LAMP: a database linking antimicrobial peptides","volume":"8","author":"Zhao","year":"2013","journal-title":"PLoS One"},{"key":"2020082519170323900_ref16","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/s41597-019-0154-y","article-title":"DRAMP 2.0, an updated data repository of antimicrobial peptides","volume":"6","author":"Kang","year":"2019","journal-title":"Sci. Data"},{"key":"2020082519170323900_ref17","doi-asserted-by":"crossref","first-page":"D1147","DOI":"10.1093\/nar\/gkt1191","article-title":"AVPdb: a database of experimentally validated antiviral peptides targeting medically important viruses","volume":"42","author":"Qureshi","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"2020082519170323900_ref18","doi-asserted-by":"crossref","DOI":"10.1093\/database\/bau051","article-title":"ParaPep: a web resource for experimentally validated antiparasitic peptide sequences and their structures","volume":"2014","author":"Mehta","year":"2014","journal-title":"Database"},{"key":"2020082519170323900_ref19","doi-asserted-by":"crossref","first-page":"e54908","DOI":"10.1371\/journal.pone.0054908","article-title":"HIPdb: a database of experimentally validated HIV inhibiting peptides","volume":"8","author":"Qureshi","year":"2013","journal-title":"PLoS One"},{"key":"2020082519170323900_ref20","doi-asserted-by":"crossref","first-page":"D1108","DOI":"10.1093\/nar\/gkr1063","article-title":"DAMPD: a manually curated antimicrobial peptide database","volume":"40","author":"Sundararajan","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"2020082519170323900_ref21","doi-asserted-by":"crossref","first-page":"D963","DOI":"10.1093\/nar\/gkn655","article-title":"PhytAMP: a database dedicated to antimicrobial plant peptides","volume":"37","author":"Hammami","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"2020082519170323900_ref22","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1111\/j.1574-6968.2008.01357.x","article-title":"RAPD: a database of recombinantly-produced antimicrobial peptides","volume":"289","author":"Li","year":"2008","journal-title":"FEMS Microbiol. Lett."},{"key":"2020082519170323900_ref23","doi-asserted-by":"crossref","first-page":"e73957.","DOI":"10.1371\/journal.pone.0073957","article-title":"In silico approach for predicting toxicity of peptides and proteins","volume":"8","author":"Gupta","year":"2013","journal-title":"PLoS One"},{"key":"2020082519170323900_ref24","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/1471-2180-10-22","article-title":"BACTIBASE second release: a database and tool platform for bacteriocin characterization","volume":"10","author":"Hammami","year":"2010","journal-title":"BMC Microbiol."},{"key":"2020082519170323900_ref25","doi-asserted-by":"crossref","first-page":"764834","DOI":"10.1155\/2012\/764834","article-title":"The design and construction of K11: a novel alpha-helical antimicrobial peptide","volume":"2012","author":"Jin-Jiang","year":"2012","journal-title":"Int. J. Microbiol."}],"container-title":["Database"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/database\/article-pdf\/doi\/10.1093\/database\/baaa061\/33679481\/baaa061.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/database\/article-pdf\/doi\/10.1093\/database\/baaa061\/33679481\/baaa061.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,25]],"date-time":"2020-08-25T23:17:47Z","timestamp":1598397467000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/database\/article\/doi\/10.1093\/database\/baaa061\/5896711"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,1]]},"references-count":25,"URL":"https:\/\/doi.org\/10.1093\/database\/baaa061","relation":{},"ISSN":["1758-0463"],"issn-type":[{"value":"1758-0463","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020]]},"published":{"date-parts":[[2020,1,1]]},"article-number":"baaa061"}}