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While the mechanism of each function has been investigated for many heme proteins, the origin of the diversity of the heme functions is still unclear and a crucial scientific issue. We have constructed a database of heme proteins, named Python-based database and analyzer for DIStortion of Heme porphyrin (PyDISH), which also contains some analysis tools. The aim of PyDISH is to integrate the information on the structures of hemes and heme proteins and the functions of heme proteins. This database will provide the structure\u2013function relationships focusing on heme porphyrin distortion and lead to the\u00a0elucidation of the origin of the functional diversity of heme proteins. In addition, the insights obtained from the database can be used for the design of protein function. PyDISH contains the structural data of more than 13\u2009000 hemes extracted from the Protein Data Bank, including heme porphyrin distortion, axial ligands coordinating to the heme and the orientation of the propionate sidechains of heme. PyDISH also has information about the protein domains, including Uniprot ID, protein fold by CATH\u00a0ID, organism, coordination distance and so on. The analytical tools implemented in PyDISH allow users to not only browse and download the data but also analyze the structures of heme porphyrin by using the analytical tools implemented in PyDISH. PyDISH users will be able to utilize the obtained results for the design of protein function.<\/jats:p>\n               <jats:p>Database URL: http:\/\/pydish.bio.info.hiroshima-cu.ac.jp\/<\/jats:p>","DOI":"10.1093\/database\/baaa066","type":"journal-article","created":{"date-parts":[[2020,8,4]],"date-time":"2020-08-04T19:16:59Z","timestamp":1596568619000},"source":"Crossref","is-referenced-by-count":10,"title":["PyDISH: database and analysis tools for heme porphyrin distortion in heme proteins"],"prefix":"10.1093","volume":"2023","author":[{"given":"Hiroko X","family":"Kondo","sequence":"first","affiliation":[{"name":"School of Regional Innovation and Social Design Engineering, Faculty of Engineering, Kitami Institute of Technology , 165 Koen-cho, Kitami, Hokkaido 090-8507, Japan"},{"name":"Department of Biomedical Information Sciences, Graduate School of Information Sciences, Hiroshima City University , 3-4-1 Ozukahigashi Asaminamiku, Hiroshima 731-3194, Japan"},{"name":"Laboratory for Computational Molecular Design, RIKEN Center for Biosystems Dynamics Research , 6-2-3, Furuedai, Suita 565-0874, Japan and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Kanematsu","sequence":"additional","affiliation":[{"name":"Department of Biomedical Information Sciences, Graduate School of Information Sciences, Hiroshima City University , 3-4-1 Ozukahigashi Asaminamiku, Hiroshima 731-3194, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gen","family":"Masumoto","sequence":"additional","affiliation":[{"name":"Information Systems Division, RIKEN Head Office for Information Systems and Cybersecurity , 2-1 Hirosawa, Wako, Saitama 351-0198, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Takano","sequence":"additional","affiliation":[{"name":"Department of Biomedical Information Sciences, Graduate School of Information Sciences, Hiroshima City University , 3-4-1 Ozukahigashi Asaminamiku, Hiroshima 731-3194, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,10,3]]},"reference":[{"key":"2023122906493480100_R1","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1039\/b604195g","article-title":"The Janus nature of heme","volume":"24","author":"Poulos,","year":"2007","journal-title":"Nat. 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