{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T13:35:42Z","timestamp":1781789742719,"version":"3.54.5"},"reference-count":42,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2020,11,13]],"date-time":"2020-11-13T00:00:00Z","timestamp":1605225600000},"content-version":"vor","delay-in-days":317,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62072124, 61702122, 61963004 and 61972185"],"award-info":[{"award-number":["62072124, 61702122, 61963004 and 61972185"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012547","name":"Natural Science Foundation of Guangxi Zhuang Autonomous Region","doi-asserted-by":"publisher","award":["2017GXNSFDA198033 and 2018GXNSFBA281193"],"award-info":[{"award-number":["2017GXNSFDA198033 and 2018GXNSFBA281193"]}],"id":[{"id":"10.13039\/100012547","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Science and Technology Base and talent Special project of Guangxi","award":["AD20159044"],"award-info":[{"award-number":["AD20159044"]}]},{"name":"Key Research and Development Plan of Guangxi","award":["AB17195055"],"award-info":[{"award-number":["AB17195055"]}]},{"name":"the foundation of Guangxi University","award":["20190240 and XBZ180476"],"award-info":[{"award-number":["20190240 and XBZ180476"]}]},{"name":"the Natural Science Foundation of Yunnan Province of China","award":["2019FA024"],"award-info":[{"award-number":["2019FA024"]}]},{"name":"Hunan Provincial Science and Technology Program","award":["2018WK4001"],"award-info":[{"award-number":["2018WK4001"]}]},{"name":"the scientific Research Foundation of Hunan Provincial Education Department","award":["18B469"],"award-info":[{"award-number":["18B469"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Accumulating evidences have shown that the deregulation of circRNA has close association with many human cancers. However, these experimental verified circRNA\u2013cancer associations are not collected in any database. Here, we develop a manually curated database (circR2Cancer) that provides experimentally supported associations between circRNAs and cancers. The current version of the circR2Cancer contains 1439 associations between 1135 circRNAs and 82 cancers by extracting data from existing literatures and databases. In addition, circR2Cancer contains the information of cancer exacted from Disease Ontology and basic biological information of circRNAs from circBase. At the same time, circR2Cancer provides a simple and friendly interface for users to conveniently browse, search and download the data. It will be a useful and valuable resource for researchers to understanding the regulation mechanism of circRNA in cancers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Database URL<\/jats:title><jats:p>http:\/\/www.biobdlab.cn:8000<\/jats:p><\/jats:sec>","DOI":"10.1093\/database\/baaa085","type":"journal-article","created":{"date-parts":[[2020,9,10]],"date-time":"2020-09-10T19:10:51Z","timestamp":1599765051000},"source":"Crossref","is-referenced-by-count":65,"title":["CircR2Cancer: a manually curated database of associations between circRNAs and cancers"],"prefix":"10.1093","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5839-7504","authenticated-orcid":false,"given":"Wei","family":"Lan","sequence":"first","affiliation":[{"name":"School of Computer, Electronic and Information, Guangxi University, No.100 Daxue East Road, Nanning, Guangxi, 530004, China"},{"name":"Hunan Provincial Key Lab on Bioinformatics, School of Computer Science and Engineering, Central South University, No. 932 Lushan South Road, Changsha, Hunan, 410083, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingrui","family":"Zhu","sequence":"additional","affiliation":[{"name":"School of Computer, Electronic and Information, Guangxi University, No.100 Daxue East Road, Nanning, Guangxi, 530004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4122-3767","authenticated-orcid":false,"given":"Qingfeng","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Computer, Electronic and Information, Guangxi University, No.100 Daxue East Road, Nanning, Guangxi, 530004, China"},{"name":"State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, Guangxi University, No.100 Daxue East Road, Nanning, Guangxi, 530004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baoshan","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, Guangxi University, No.100 Daxue East Road, Nanning, Guangxi, 530004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Liu","sequence":"additional","affiliation":[{"name":"Hunan Provincial Key Lab on Bioinformatics, School of Computer Science and Engineering, Central South University, No. 932 Lushan South Road, Changsha, Hunan, 410083, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Li","sequence":"additional","affiliation":[{"name":"Hunan Provincial Key Lab on Bioinformatics, School of Computer Science and Engineering, Central South University, No. 932 Lushan South Road, Changsha, Hunan, 410083, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Ping Phoebe","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Computer Science and Information Technology, La Trobe University Plenty Rd & Kingsbury Dr, Melbourne, Vic 3086, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,11,11]]},"reference":[{"key":"2020111216461442300_R1","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1126\/science.1238522","article-title":"A circuitous route to noncoding RNA","volume":"340","author":"Wilusz","year":"2013","journal-title":"Science"},{"key":"2020111216461442300_R2","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/j.molcel.2015.03.027","article-title":"Circular RNAs in the mammalian brain are highly abundant, conserved, and dynamically expressed","volume":"58","author":"Rybak-Wolf","year":"2015","journal-title":"Mol. 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