{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T20:05:05Z","timestamp":1771272305385,"version":"3.50.1"},"reference-count":41,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2021,3,9]],"date-time":"2021-03-09T00:00:00Z","timestamp":1615248000000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31670851 and 32070671"],"award-info":[{"award-number":["31670851 and 32070671"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2016YFC1306605"],"award-info":[{"award-number":["2016YFC1306605"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,3,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The pathogenesis of cancer is influenced by interactions among genes, proteins, metabolites and other small molecules. Understanding cancer progression at the metabolic level is propitious to the visual decoding of changes in living organisms. To date, a large number of metabolic biomarkers in cancer have been measured and reported, which provide an alternative method for cancer precision diagnosis, treatment and prognosis. To systematically understand the heterogeneity of cancers, we developed the database CMBD to integrate the cancer metabolic biomarkers scattered over literatures in PubMed. At present, CMBD contains 438 manually curated relationships between 282 biomarkers and 76 cancer subtypes of 18 tissues reported in 248 literatures. Users can access the comprehensive metabolic biomarker information about cancers, references, clinical samples and their relationships from our online database. As case studies, pathway analysis was performed on the metabolic biomarkers of breast and prostate cancers, respectively. \u2018Phenylalanine, tyrosine and tryptophan biosynthesis\u2019, \u2018phenylalanine metabolism\u2019 and \u2018primary bile acid biosynthesis\u2019 were identified as playing key roles in breast cancer. \u2018Glyoxylate and dicarboxylate metabolism\u2019, \u2018citrate cycle (TCA cycle)\u2019, and \u2018alanine, aspartate and glutamate metabolism\u2019 have important functions in prostate cancer. These findings provide us with an understanding of the metabolic pathway of cancer initiation and progression.<\/jats:p><jats:p>Database URL: http:\/\/www.sysbio.org.cn\/CMBD\/<\/jats:p>","DOI":"10.1093\/database\/baaa094","type":"journal-article","created":{"date-parts":[[2020,10,14]],"date-time":"2020-10-14T19:13:43Z","timestamp":1602702823000},"source":"Crossref","is-referenced-by-count":17,"title":["CMBD: a manually curated cancer metabolic biomarker knowledge database"],"prefix":"10.1093","volume":"2021","author":[{"given":"Jing","family":"Chen","sequence":"first","affiliation":[{"name":"Institutes for Systems Genetics, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China"},{"name":"The School of Science, Kangda College of Nanjing Medical University, Lianyungang, Jiangsu 222000, China"}]},{"given":"Xingyun","family":"Liu","sequence":"additional","affiliation":[{"name":"Institutes for Systems Genetics, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China"}]},{"given":"Li","family":"Shen","sequence":"additional","affiliation":[{"name":"Institutes for Systems Genetics, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China"}]},{"given":"Yuxin","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Urology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2899-1531","authenticated-orcid":false,"given":"Bairong","family":"Shen","sequence":"additional","affiliation":[{"name":"Institutes for Systems Genetics, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China"}]}],"member":"286","published-online":{"date-parts":[[2021,3,9]]},"reference":[{"key":"2021031107060057300_R1","first-page":"307","article-title":"On the origin of the cancer cells","volume":"58","author":"Braun","year":"1970","journal-title":"Am. 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