{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T07:38:38Z","timestamp":1765438718817,"version":"3.41.2"},"reference-count":39,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T00:00:00Z","timestamp":1618963200000},"content-version":"vor","delay-in-days":110,"URL":"http:\/\/www.nationalarchives.gov.uk\/doc\/open-government-licence\/version\/3\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2016YFA0501703"],"award-info":[{"award-number":["2016YFA0501703"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31801037"],"award-info":[{"award-number":["31801037"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,4,21]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Transcription factors (TFs) are DNA-binding proteins, which regulate many essential biological functions. In several cancer types, TF function is altered by various direct mechanisms, including gene amplification or deletion, point mutations, chromosomal translocations, expression alterations, as well as indirectly by non-coding DNA mutations influencing the binding of the TF. TFs are also actively involved in breast cancer (BC) initiation and progression. Herein, we have developed an open-access database, BC-TFdb (Breast Cancer Transcription Factors database), of curated, non-redundant TF involved in BC. The database provides BC driver TFs related information including genomic sequences, proteomic sequences, structural data, pathway information, mutations information, DNA binding residues, survival and therapeutic resources. The database will be a useful platform for researchers to obtain BC-related TF\u2013specific information. High-quality datasets are downloadable for users to evaluate and develop computational methods for drug designing against BC.<\/jats:p><jats:p>Database URL: https:\/\/www.dqweilab-sjtu.com\/index.php.<\/jats:p>","DOI":"10.1093\/database\/baab018","type":"journal-article","created":{"date-parts":[[2021,4,10]],"date-time":"2021-04-10T11:30:18Z","timestamp":1618054218000},"source":"Crossref","is-referenced-by-count":5,"title":["BC-TFdb: a database of transcription factor drivers in breast cancer"],"prefix":"10.1093","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4288-7602","authenticated-orcid":false,"given":"Abbas","family":"Khan","sequence":"first","affiliation":[{"name":"Department of Bioinformatics and Biological Statistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, P.R. China"}]},{"given":"Taimoor","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics and Biological Statistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, P.R. China"}]},{"given":"Syed Nouman","family":"Nasir","sequence":"additional","affiliation":[{"name":"Center for Biotechnology and Microbiology, University of Swat, Swat, KP 19200, Pakistan"}]},{"given":"Syed Shujait","family":"Ali","sequence":"additional","affiliation":[{"name":"Center for Biotechnology and Microbiology, University of Swat, Swat, KP 19200, Pakistan"}]},{"given":"Muhammad","family":"Suleman","sequence":"additional","affiliation":[{"name":"Center for Biotechnology and Microbiology, University of Swat, Swat, KP 19200, Pakistan"}]},{"given":"Muhammad","family":"Rizwan","sequence":"additional","affiliation":[{"name":"Center for Biotechnology and Microbiology, University of Swat, Swat, KP 19200, Pakistan"}]},{"given":"Muhammad","family":"Waseem","sequence":"additional","affiliation":[{"name":"Faculty of Rehabilitation and Allied Health Science, Riphah International University, Islamabad 44000, Pakistan"}]},{"given":"Shahid","family":"Ali","sequence":"additional","affiliation":[{"name":"Center for Biotechnology and Microbiology, University of Swat, Swat, KP 19200, Pakistan"}]},{"given":"Xia","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Army Medical University, Chongqing 400044, P.R. China"}]},{"given":"Dong-Qing","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics and Biological Statistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, P.R. China"},{"name":"State Key Laboratory of Microbial Metabolism, Shanghai-Islamabad-Belgrade Joint Innovation Center on Antibacterial Resistances, Joint International Research Laboratory of Metabolic and Developmental Sciences and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, P.R. China"},{"name":"Peng Cheng Laboratory, Vanke Cloud City Phase I Building 8, Xili Street, Nanshan District, Shenzhen, Guangdong 518055, P.R. China"}]}],"member":"286","published-online":{"date-parts":[[2021,4,21]]},"reference":[{"key":"2021070818440482100_R1","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1016\/j.cell.2013.02.014","article-title":"Transcriptional regulation and its misregulation in disease","volume":"152","author":"Lee","year":"2013","journal-title":"Cell"},{"key":"2021070818440482100_R2","doi-asserted-by":"crossref","DOI":"10.1038\/srep15215","article-title":"Transcription factor and miRNA co-regulatory network reveals shared and specific regulators in the development of B cell and T cell","volume":"5","author":"Lin","year":"2015","journal-title":"Sci. Rep."},{"key":"2021070818440482100_R3","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.gpb.2018.12.008","article-title":"Transcriptome and regulatory network analyses of CD19-CAR-T immunotherapy for B-ALL","volume":"17","author":"Zhang","year":"2019","journal-title":"Genom. Proteom. 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